PubMed Health⌕ Search

Biomedical subjects

F Branconi

Publications and source records attributed to F Branconi.

At least 37 records · Page 2Linked to original sources
PubMed1984

Polychemotherapy in ovarian cancer: treatment with Adriamycin, BCNU and cyclophosphamide vs. Adriamycin and cyclophosphamide.

The authors compared both therapeutic efficacy and toxicity of two different treatment regimens: ABC = adriamycin, nitrogen mustard (BCNU) and cyclophosphamide (CTX) vs. AC = adriamycin and cyclophosphamide in ovarian cancer. Thirty-one patients were entered under treatment plan ABC and 26 under treatment plan AC simultaneously. Therapeutic evaluation was subdivided into different risk groups (adjuvant therapy, residual disease less than or greater than 2 cm). A similar result could be noted in the two different treatment regimens. Toxicity was more severe and frequent in the group treated with BCNU. The AC regimen was preferred because of its lower incidence of side-effects and for its easier mode of administration.

Adenocarcinoma↗
PubMed1983

The microcolposcopy in the management of the cervical intraepithelial neoplasia.

The authors report their experience with the microcolpohysteroscope of Hamou. This instrument allows a magnification from 0 to 150 times. Its fine caliber (4 mm) allows to work easily also in the interior of the cervical canal, without preventive dilatation. The instrument allows the in vivo vision of the cellular arrangement at the superficial level, after vital staining. The purpose of this research is the discussion of the potentiality of the microcolpohysteroscopy as complementary mean to colposcopy, citology and histology in the management of the Cervical Intraepithelial Neoplasia (CIN). The authors conclude showing the advantages of this technique underlining as this method does not interfere with the natural evolution of the pathologic process, allowing at the contrary to determine the nature and the extension of the lesion. Then, without opposing or to citology or to colposcopy or to histology, it is not only a valid complementary diagnostic mean, but in particularly it contributes to a more rational therapeutic decision.

Carcinoma in Situ↗
PubMed1983

p-p'DDT in perinatal samples: report on maternal and neonatal measurements.

Organochlorine pesticides and their degradation products can affect humans in several ways and are detected in human tissue, including placental tissue and umbilical cord blood. We report the results of preliminary research conducted to determine the levels of p-p'DDT in maternal and umbilical cord blood during labor and to estimate the possible consequences of this product for calcium metabolism. The results confirm that p-p'DDT is transferred to the fetus through the placenta and indicate the existence of a complex fetal-maternal p-p'DDT distribution mechanism.

Calcium↗
PubMed1983

Pre-neoplastic lesions of vulvar cancer.

The monitoring of potentially neoplastic lesions is based on the determination of the histopathologic characteristics of the lesion, which is done either by large surgical resection of the lesions "in toto" or by biopsy of the lesion. Chronic vulvar dystrophy may develop into carcinoma, the supposed likelihood varying according to the various Authors. The lesion which is histologically defined as atypical keratoacanthoma is the most frequent precursor of carcinoma. Most Authors agree in believing that lichen scleroatrophic does not often develop into carcinoma. It is, nevertheless, the most frequent precursor of leukoplakia which is, on the other hand, a risk lesion. However, any chronic vulvar irritation may increase the risk of cancer and must therefore be carefully monitored by multiple biopsies to be examined at regular intervals.

Aged↗
PubMed1982

Evaluation of fetal heart rate variability.

Fetal heart rate (FHR) variability appears to be an "early warning system" of fetal hypoxia. FHR variability has been utilized in clinical practice to examine fetal wellbeing. Since 1976 we have used a standardized scoring system to evaluate the cardiotocograph. To eliminate subjective aspects in FHR variability analysis we propose a programmable device utilizing a microprocessor. Preliminary results encourage us to continue this research.

Computers↗
PubMed1982

Usefulness of hysteroscopy in endometrial adenocarcinoma staging.

Endometrial carcinoma has an absolutely unfavourable prognosis when it involves the cervix. Clinical staging, which is essential to a correct therapeutical approach, has proven quite wrong when relying on endocervical curettage. This work deals with the use of Hamou's microhysteroscope to assess the endocervical diffusion of endometrial cancer. Thanks to its very high sensitivity (100%), high specificity (89%) and diagnostic accuracy (92%), this method has proven extremely reliable in the clinical staging of endometrial carcinoma.

Endoscopes↗
PubMed1981

Plasma hormone assay in pregnancy.

This paper reports the results obtained with various hormonal parameters (HPL, E3, alpha-FP) in evaluating fetal wellbeing during pathologic pregnancies. The expression of hormonal parameters in terms of standard deviation (S.D.) provides a constant endocrine index throughout pregnancy, independently of the adopted parameter. Such methodology reduces error and simplifies interpretation of data. The hormonal index is important not only for reliable diagnosis of a pathologic situation, but also because of its simple interpretation for clinical and practical purposes.

Estriol↗
PubMed1979

A pregnancy in an acromegalic woman during bromocriptine treatment: effects on growth hormone and prolactin in the maternal, fetal, and amniotic compartments.

An unexpected 20-week-old pregnancy was found in a young acromegalic who had been treated with 10 mg bromocriptine/day for 10 months. The drug was continued throughout the period of gestation. No growth of the pituitary adenoma was noticed. The intrauterine development of the fetus was normal. Bromocriptine therapy had no discernible effect on the expected patterns of secretion of placental hormones, but inhibited completely the increase of PRL in the serum of the mother. Maternal plasma GH concentrations were very high in spite of the treatment and progressively declined after delivery. The plasma GH level was normal in the child, but PRL was very low at birth and increased in the following days. The expected high PRL concentration was found in the amniotic fluid. This case study suggests that bromocriptine crosses the human placenta and affects the fetal pituitary, maternal GH does not influence fetal or amniotic GH, and amniotic fluid PRL correlates poorly with either maternal or fetal blood levels and is not affected by bromocriptine.

Acromegaly↗
PubMed1976

Plasmatic prekallikrein and kallikrein inhibitor in pregnancy, labor and in newborn.

In order to reveal the possible physiological role of the kallikrein during the stress of birth, the prekallikrein and kallikrein inhibitor were evaluated in 15 pregnant women and in 15 newborns from terminated pregnancies. The results show a very low level of prekallikrein in the funiculus blood at the moment of birth and a still lower level in venous blood 24 hours after birth. No important changes resulted in the mother's blood either in pregnancy, nor at the end of the labour.

Aprotinin↗