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Biomedical subjects

F Brunner

Publications and source records attributed to F Brunner.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Psychiatric aspects in the starting and ending of chronic dialysis].

Various symptoms are discussed which are of importance in patients undergoing maintenance dialysis for chronic renal failure, such as depression, organic brain syndrome, ambiguity regarding a chronic "incurable" disease, sexual dysfunction and suicidal behaviour. A number of criteria that should be considered at the beginning and termination of regular dialysis treatment are described. Six case reports of selected patients with chronic renal failure and psychiatric problems are discussed. For psychiatric reasons one female patient was not started on maintenance dialysis. One of the patients, a female, did well on maintenance dialysis. One patient died due to medical complications for which treatment was withheld. Two patients decided to quit maintenance dialysis with their doctor's approval. One patient committed suicide unexpectedly.

Depression↗
PubMed1980

[Blood transfusions and kidney transplantation: selection or conditioning of recipients?].

Pretransplant blood transfusions have been shown in retrospective studies to prolong the survival of kidney grafts. We have therefore introduced a new prospective transfusion policy. All patients waiting for a kidney transplant received if possible 5 transfusions at monthly intervals, then 1 every 6 months. From 1.1. 1977 to 31.12. 1978 we transplanted 51 transfused patients. In the present study we investigated: 1. the occurrence of lymphocytotoxic antibodies, 2. the time on dialysis until transplantation and 3. the kidney graft survival. 65% of all patients never had antibodies. Only 6 patients produced antibodies with broad spectrum activity. The occurrence of these antibodies did not significantly influence the graft survival. The majority of the patients without antibodies waited 5 months for transplantation. The few hyperimmunized waited far longer, but nevertheless all finally got a transplant. The actuarial graft survival rate at 1 year was 72%. The results of our program with systematic pretransplant transfusions indicate that the advantages of transfusions override the risk of hyperimmunisation.

Antibody Formation↗
PubMed1977

[Cranial mucormycosis in a patient with a transplanted kidney].

Mucormycosis is a very serious complication of debilitating diseases, and particularly of diabetes. Presently the treatment of choice is amphotericine B. A patient is described who, like most other renal transplant patients with mucormycosis, had cranial localization of this disease and diabetes. The clinical findings were classical and the diagnosis was confirmed histologically.

Adult↗
PubMed1977

[Porphyria cutanea tarda-like bullous dermatosis in a patient with chronic renal failure under hemodialysis].

Patients with chronic renal failure under regular hemodialysis may present porphyria cutanea tarda-like dermatoses without, however, exhibiting a disturbed porphyrin metabolism. Based on a personal observation and the literature the anamnestic, clinical and histological features of this distinct dermatosis are discussed. Metabolic disturbances due to chronic renal failure, with or without hemodialysis, are possible etiopathogenetic factors, while in the light of the latest findings it seems improbable that any such role is played by frusemide therapy.

Humans↗
PubMed1977

[Blood transfusion and kidney transplantation].

The non-transfusion policy for potential recipients of kidney allografts that has been followed in recent years has not proven successful. There is now ample clinical evidence of improved transplant function in the transfused recipients category. This has also been confirmed in recipients of a first cadaver kidney in Basel and Geneva. If the conditions valid for human kidney transplantation are matched as closely as possible in animal experiments, prolongation of graft function rather than accelerated rejection is usually observed after blood transfusions. Potential kidney graft recipients should be more liberally transfused and experimental evidence ought to be accumulated in order to establish a rationale for optimal host conditioning, while avoiding the hazards of blood transfusions to the greatest extent possible.

Animals↗
PubMed1976

Hyperlipidemias in patients with kidney transplants.

Serum lipids in 58 renal transplant recipients were related to duration of follow-up, relative body weight, steroid medication, proteinuria and graft performance. Hyperlipidemia was observed between the 4th month and the end of the first year after transplantation in 83% of the patients. Thereafter, the frequency of hyperlipidaemia appeared to decrease: at 4 to 7 years only 61% of the subjects continued to exhibit abnormal high serum lipids. Three mechanisms leading to hyperlipidaemia were identified: 1) overweight, 2) steroid mediation, 3) proteinuria. A forth apparent mechanism was impaired transplant function.

Age Factors↗
PubMed1976

Etiologic and prognostic significance of isolated acute renal hypoxic change (so-called tubular necrosis or shock kidney) in kidney transplants.

20 biopsies were studied in order to determine whether or not the pathologist is able to predict on morphological grounds the etiology and prognosis of acute renal hypoxic change in renal transplants. We concluded that: 1) Intertubular blood stasis seems to be pathognomonic of peripheral vascular rejection and/or renal artery thrombosis. 2) A focal distribution of acute tubular luminal dilatation suggests peripheral vascular rejection. 3) The finding of lymphatic casts suggests the presence of ureteric obstruction. 4) Linear fluorescent staining of the peripheral glomerular basement membrane appears to be due to leakage of plasma proteins in the presence of endothelial damage. 5) The histological distinction between camouflaged rejection and genuine shock kidney is impossible in a biopsy. 6) The precise cause of acute renal hypoxic change and the prognosis of kidney transplants with this alteration often cannot be determined.

Acute Kidney Injury↗