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Biomedical subjects

F Buch

Publications and source records attributed to F Buch.

9 recordsLinked to original sources
PubMed1995

Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).

In a prospective, randomized, double-blind study of radial epicondylalgia (tennis elbow), 109 patients with an average symptom duration of 8 months were considered for treatment with a single 1-mL injection of the steroid triamcinolone combined with either lidocaine or bupivacaine. The patients received clinical examinations at regular intervals for 1 year, and followup included visual analog pain scale and questionnaires. The 2 groups were comparable and for many factors distributed completely evenly with respect to gender, age, symptom duration, side dominance, type of pain onset, earlier treatment, and occupational loading. The only difference between the groups receiving lidocaine or bupivacaine was found at 2 weeks, when the bupivacaine additive yielded a better outcome for patients who had not been treated in any way before, for those with a short history of epicondylalgia, or both. The steroid injection treatment, regardless of which local anesthetic was given, presented a typical pattern, with symptoms relieved quickly by 2 weeks and then deterioration for many patients at 3 months, indicating a tendency to recurrence. A considerable loss of patients to other treatments at the 1-year followup indicated an equivocal long-term result. Patients who had not been treated earlier in any way had a more favorable prognosis, as did those with a history of epicondylalgia to 3 months.

Adolescent↗
PubMed1990

Bone formation in porous implants of delrin and commercially pure titanium.

Clinicians have been using implants made by titanium or delrin with varying results. In this study dividable implants, bone growth chambers (BGC), of titanium and delrin were inserted into the rabbit tibia. The ingrowth of hard tissue into a canal in the implant was evaluated after 3 weeks by microradiography and numerically determined by computer analysis. Results showed that bone ingrowth into titanium implants was significantly larger than into delrin implants (P less than 0.005). The possible reasons for this are discussed.

Animals↗
PubMed1988

Influence of direct currents on bone vascular supply.

Electrical stimulation with a DC of 5 microA was found to result in macromolecular leakages in the microcirculation of rabbit metaphyseal bone. The blood flow rate of living bone did not change during 2.5 hours of electrical stimulation. Over a follow-up time of up to 11 weeks it was observed that vessels close to bone borders increased in size and that the number of bone capillaries increased, simultaneous with an increase in bone formation.

Animals↗
PubMed1988

Bone formation rate in osseointegrated titanium implants. Influence of locally applied haemostasis, peripheral blood, autologous bone marrow and fibrin adhesive system (FAS).

The influence of local application of haemostasis, peripheral blood, autologous bone marrow and Fibrin Adhesive System (FAS) on bone formation rate in osseointegrated titanium implants, were studied. The Bone Harvest Chamber (BHC) implant utilized has a penetrating canal, enabling osseous ingrowth in situ. After integration of one implant into the cortex of the proximal tibial metaphysis of a rabbit, newly formed bone was harvested in repetitive three-week periods. The specimens were quantified by microradiography-videodensitometry and subjected to further histological examination. The amounts of bone formed in two equally treated chambers in the same animal were compared. It was concluded, that the conditions for bone regeneration in an osseointegrated titanium implant are excellent, minimally influenced by locally applied haemostasis, peripheral blood and autologous bone marrow. FAS pretreatment on the other hand was found to impair bone formation.

Animals↗
PubMed1986

The bone growth chamber for quantification of electrically induced osteogenesis.

A dividable titanium implant was inserted in the tibial metaphysis of rabbits, which permitted a numerical evaluation of ingrowing bone. The implant on the test side was used as cathode and was connected to a subcutaneously located stimulator delivering constant current of either 5 microA, 20 microA, or 50 microA. A corresponding control implant was inserted in the other tibia of the same animal and treated likewise, but was not connected to the stimulator. Distally to each implant, a platinum-iridium screw was inserted into the cortex and connected on the test side to the stimulator to serve as the anode. The results showed a 2.4-fold increase in bone formation with 5 microA. In the 20-microA group, there was 2.6-fold more bone in the test chambers. Direct current (DC) stimulation with 50 microA caused a clear decrease of bone volume, with an average of 48% less bone in the test implants. The results indicate that 5 and 20 microA direct current enhance bone ingrowth into a titanium implant that is used as a cathode. The osteogenesis seemed to be more pronounced in the case where the chamber was used as a cathode compared to earlier experiments in which the cathode was placed at a distance of 5 mm from the implant.

Animals↗
PubMed1985

Effects of direct currents on bone growth into delrin implants.

The delrin Bone Growth Chamber (BGC) which is a dividable implant, was inserted in its assembled form in the tibial metaphysis of the rabbit. The BGC allows a numerical estimation of the bone growth into the implant, based on microradiography and microdensitometry that permits evaluation of direct current (DC) effects on bone regeneration. A test chamber was inserted in one tibia and was stimulated with either 5, 20 or 50 microA for three weeks, while on the contralateral side of the same animal, a control implant was inserted under identical conditions as the test, but was not stimulated. The results showed a significant increase of bone growth with 20 and 50 microA and a tendency towards more bone formation with 5 microA.

Animals↗
PubMed1985

Vascular reactions during electrical stimulation. Vital microscopy of the hamster cheek pouch and the rabbit tibia.

Vital microscopy during electrical stimulation was performed in the hamster cheek pouch and the rabbit tibia. Stimulation with DC of 5,20 or 50 microA or AC of 20 microA was demonstrated to cause macromolecular capillary leakage as evidenced by FITC-dextran fluorescence and histological demonstration of extravasated white blood cells. It was further demonstrated that the vascular leakage was blocked by administration of indomethacin. Pulsed electromagnetical fields did not visibly affect the vascular permeability within 3 h. As the same DC electrical stimulator has been demonstrated to increase the osteogenic capacity in similar titanium implants in the rabbit tibia, it is suggested that the observation of macromolecular leakage may predict a positive osteogenic response.

Animals↗
PubMed1984

Direct current influence on bone formation in titanium implants.

A dividable, titanium implant was inserted bilaterally in assembled form in the tibial metaphyses of adult rabbits. A titanium cathode was placed 5 mm proximal and a platinum-iridium anode 5 mm distally. The chamber on one side served as a non-stimulated control: on the other side the electrodes were connected to a constant current generator. Ten animals were treated with 5 microA, ten with 20 microA and ten with 50 microA. After three weeks the implants were removed, taken apart and the bone which had grown into two central canals of the chamber was collected for macroradiographic and computer-based numerical analysis. DC-stimulation with 50 microA did not result in any measurable increase of bone formation in the test implants compared to the controls. After stimulation with 5 or 20 microA, on the other hand, there was a statistically significant increase of osteogenesis, in spite of the fact that the electrodes were situated at some distance from the implant.

Animals↗