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Biomedical subjects

F Buchholz

Publications and source records attributed to F Buchholz.

44 records · Page 3Linked to original sources
PubMed1983

CIN and preclinical cervical carcinoma. A study of morbidity trends over a 10-year period.

Between 1971 and 1980 1312 cone biopsies were performed at the Department of Gynecology and Obstetrics, Kiel. Comparing the two intervals from 1971 to 1975 and 1976 to 1980 the number of cases with dysplasia and Carcinoma in situ significantly rose in the last 5 years in patients 16-30 years of age. Amongst other reasons for this increase, on the basis of our investigation, the regular gynecological examination in combination with the prescription of the ovulation inhibitors seems to be responsible. The average age of patients (36-44 years) undergoing cone biopsy for the first time decreased in the period between 1971 and 1980 (approx. 8 years). The excision of carcinoma in situ in women under 30 years of age mostly showed margins free of pathological epithelium. With increasing age the cases of not free margins increased to 70%. For the hemostasis of the conization crater up to 1977, the conventional suture technique was applied, since 1977 cone coagulation probe according to Semm was used. In this group (1977-1980) treated with coagulation after cone biopsy, 45% of the cases with carcinoma in situ not free margins had histologically normal epithelium of the extirpated uterus. In patients with the desire for a child or in pregnant women a secondary coagulation of the wound crater is achieved to preserve the uterus.

Adolescent↗
PubMed1982

[Pretreatment of carcinoma in situ and microcarcinoma of the cervix by conization and endocoagulation (author's transl)].

65 microcarcinomas and 189 Ca. in situ-cases were diagnosed by cone biopsy in the Department of Gynaecology and Obstetrics of the University in Kiel in the periods 1973-1976 and 1977-1980. During the first period the haemostasis of the conization crater was obtained by the conventional techniques. In 38% (microcarcinoma) and 30% (Ca. in situ) of the cases the excised uterus was free of pathological epithelium. Since 1977 we have used simple coagulation of the wound area, with endocoagulation-technique according to Semm. In the second group (1977-1980), 73% (microcarcinoma) and 45% (Ca. in situ) were histologically normal, and only one case showed remaining microcarcinoma in the excised uterus. In individual cases--such as during pregnancy or where the patient still desires to have children--the Ca. in situ with not free margins, can be treated simply with a secondary coagulation of the wound crater.

Carcinoma in Situ↗
PubMed1981

[Epidemiological and diagnostic analyses of 1194 cone biopsies (author's transl)].

1194 patients of the Department of Gynecology and Obstetrics of the University in Kiel were treated by cone biopsy 1971-1979. In 92 of these cases the cone biopsy was free of pathological epithelium despite positive prefindings. The part of adeno-carcinoma of the cervix was 1.2%. In two control-periods (1971-6/75 and 7/75-1979) the quantity of 16-30 year old women with dysplasia or carcinoma in situ of the cervix was high significantly increased in the last period. The prescription of ovulation inhibitors is due to this tendency as one of other important factors. The average age of patients first treated by cone biopsy decreased from 44 years to 36 in 1971 to 1979. The majority of the carcinoma in situ was completely excised by women below 30 years old. The cases of not free margins increased to 72% with advancing in years. Over the half of patients with not completely removed carcinoma in situ or micro-carcinoma there was no pathological epithelium in the followed exstirpated uterus. The reason for this behaviour may be the hemostasis with high frequency cauterization (coagulation apparates of Semm) since 1977. The number of diagnosis of the carcinoma colli uteri Ia and Ib by cone biopsy was lower in the second control-period compared to the previous period.

Adenocarcinoma↗
PubMed1976

Results of diagnostic pelviscopy in cases of chronic recurrent pelvic disease.

During the last two years we have performed diagnostic pelviscopy in 90 patients suffering from a syndrome of chronic repeated pelvic disease. In 44 patients extragenital endometriosis was diagnosed as the causing factor. In 15 cases we found wide-spread adhesions in the region of the lower pelvis after preceeding laparotomies. Only in 12 patients pelvic-alterations caused by chronic inflammatory processes of the adnexa with peritubal adhesions were discovered. As these results show extragenital endometriosis represents in far more cases as generally believed the cause of gynecological pains. We want to give special emphasis to the diagnosis and treatment of this disease.

Adult↗
PubMedDate not supplied

Positive selection of CD56+ lymphocytes by magnetic cell sorting.

A new method for the isolation of CD56+ lymphocytes from peripheral mononuclear blood cells is described. Magnetic microbeads conjugated to goat antimouse antiserum in combination with a murine monoclonal anti-CD56 antibody were coated to the CD56+ target cells. CD56+ cells were then isolated with the use of a magnetic cell sorter. The purity of the CD56+ cells was 98.4 +/- 1% (n = 12) with a recovery of the CD56+ lymphocytes of 57.2 +/- 9% (range 48-77%). The natural killer, activity of the CD56+ lymphocytes as well as the interleukin-2-induced proliferative response were not affected by the isolation procedure or the presence of the magnetic microbeads on the CD56+ cells. The described method might be a useful tool for the further characterization of CD56+ cells and their subsets and can easily be upgraded for clinical use in adoptive immunotherapy with CD56+ lymphocytes.

Adult↗