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F Buddenhagen

Publications and source records attributed to F Buddenhagen.

10 recordsLinked to original sources
PubMed1991

Immunoadsorption and plasma exchange in multiple sclerosis: complement and plasma protein behaviour.

Three groups of patients suffering from acute attacks or progressive multiple sclerosis (MS) are under investigation. First results revealed remarkable clinical improvements of patients with acute attacks in the groups treated by therapeutic plasma exchange (TPE) and immunoadsorption (IA). Only slight or no improvements were seen in the patients of the control group treated only with steroids. Plasma protein levels (IgG, IgM, IgA, fibrinogen) were considerably reduced in patients of the TPE group after each treatment procedure as expected. The same holds true concerning the total hemolytic capacities (THC) of the complement of the classic (CP) and the alternative (AP) pathway. On the other hand in the IA group only slight decreases of plasma proteins (about 20%) were observed, but the behaviour of THC's were quite similar than those seen in the patients of the TPE group. The THC decreases in both groups can be explained by removal of all complement factors (TPE group) or by the adsorption of single factors (IA group) of both complement pathways according to earlier in vitro investigations. The THC decreases in patients of both groups suffering from acute MS attacks could mean an "antiinflammatory" effect and could--at least partially--contribute to the clinical improvements of these patients.

Blood Proteins↗
PubMed1988

Incidence of multiple sclerosis: a periodic or stable phenomenon.

For diseases of unknown aetiology, the question as to whether the incidence is constant or variable is very important. A study on multiple sclerosis in a defined northern area of the German Democratic Republic showed a prevalence of 68.6 and an incidence rate of 3.0. Retrospective and prospective investigations concerning an observation period of 22 years revealed cyclic periods (6-7 years) of high incidence rates (up to 4.5) interrupted by shorter intervals (4-5 years) with low rates (about 1.8). The differences (1963-1968 vs. 1969-1973, 1974-1978 vs. 1979-1983) are significant. In accordance with the findings of Kurtzke et al. on a cyclic outbreak of multiple sclerosis in the Faroes and Iceland, our results are considered to be a consequence of environmental factors, such as epidemic viral infections.

Adolescent↗
PubMed1988

[Effect of ultraviolet irradiation of autologous blood on cell volumes, cell adhesion and phagocytosis in normal probands and patients with multiple sclerosis].

UVB induced changes of blood cell properties were investigated in 12 MS patients and in 10 healthy volunteers serving as normal controls. The mean cell volume (MCV) was determined by electronic sizing, the granulocyte and lymphocyte adherence was estimated in a capillary assay, and the phagocytic activity of granulocytes was measured in a test system based on the incorporation of opsonized baker's yeast (Saccharomyces cerevisiae). In MS patients the MCV of red cells and lymphocytes decreased rapidly within 6 UVB treatments. In contrast, the reduction of the granulocyte volume was delayed (between the 6th and 12th UVB). In the control group the mean value of the red cell and lymphocyte MCV remained rather unaffected. There was a slight rise of the granulocyte volume after the 6th UVB. The only significant change of adherence was an increase of granulocyte adherence in MS patients. Untreated patients had a significantly enhanced phagocytic activity in comparison to the control group. 6 UVB treatments included a significant reduction of the phagocytic activity in MS patients. However, subsequently the percentage of phagocytizing cells increased again, whereas the particle uptake per cell continued to decrease. In the control group only minor UVB induced changes of phagocytosis were observed. The in vitro UV irradiation caused an enhanced phagocytosis in the majority of cases in both controls and MS patients. In general, under the UVB treatment all parameters examined changed in the sense of a normalisation, in that the measured values reached a new level lying between the extreme pretreatment values accompanied by a reduced standard deviation. The effect of UVB was more pronounced in MS patients when compared with normal controls. This could result from an enhanced sensitivity to the influence of UVB of pathologically altered cells in MS patients. The monitoring of the MCV of red cells and lymphocytes as well as the repeated testing of granulocyte phagocytosis are recommended for supportion of therapy planning and follow-up of MS patients.

Blood↗
PubMed1988

[Forms of disease progression and prognostic factors in multiple sclerosis].

Basing on the diagnostic criteria, an analysis of 687 cases of multiple sclerosis (MS) is represented according to the different forms of course, their frequency and the degree of severity. For the progressive course--either secondary after attacks or primary--a higher proportion of disease with severe disturbances resp. comparatively malignant forms have been found; furthermore, a critical time of progression could be ascertained. The determination of the disability status (using the EDSS) during a longer space of time showed a more unfavourable prognosis for the males. The development of disability was more distinct at onset of disease in the elder-aged groups. The problems of uncertain factors influencing the course and prognosis of disease are pointed out in connection with the heterogeneity of MS, basing on the pathogenetic components.

Adult↗
PubMed1988

[The problem and value of therapy in multiple sclerosis].

Some fundamental problems of therapy in multiple sclerosis (MS) and the difficulties in assessing the results of treatment are represented. Basing on a survey of several principles of therapy, the findings of own therapeutic trials using corticosteroids, immunosuppressive agents (azathioprine, cyclophosphamide, antihumanlymphocyte globulin) are pointed out; in particular, the analysis of a longer period of the course of disease produced few favourable effects. In further therapeutic studies, i.e. plasmapheresis and immunoadsorption, a long lasting observation of the course is lacking; this likewise concerns the study on ultraviolet irradiation of blood. As to the aspects of a multi-stage pathogenesis of MS an appraisal of therapeutic conceptions and procedures is given; in critical evaluation their efficacy is little convincing.

Adult↗
PubMed1987

Phagocytic activity of CSF monocytes in neurological diseases.

A standard latex phagocytosis test was used to determine the phagocytic activity of CSF monocytes under various pathological conditions. The mean values for groups of neurological diseases did not differ significantly, with the exception of tumour patients. Differences in the phagocytosis of CSF monocytes were seen if subdivisions within the groups of patients with multiple sclerosis (MS) and vertebral irritation syndrome (VIS) were evaluated separately. The active stage of MS and the intervertebral disc prolapse were accompanied by higher values. It is concluded that although the findings are of no use for diagnostic purposes they may be helpful in assessing prognosis and therapy.

Humans↗
PubMed1985

[Comparative epidemiologic analysis of multiple sclerosis in areas of Central and Southern Europe].

Epidemiological data concerning multiple sclerosis (MS) and collected by roughly the same methods in the regions of Rostock (GDR) and Schumadija-Pomoravlje (Yugoslavia) are presented. In both regions the females were earlier and more frequently attacked than the males; possible genetic, etiopathogenetic and other factors are discussed. The age at which the disease becomes manifest is about the same in both regions and was 30.9 and 30.8 years respectively. A prevalence of 60.4 and an incidence of 2.9 per 100 000 inhabitants were calculated for the Rostock region. The corresponding data for the Yugoslavian region were 20.3 (prevalence) and 0.89 (incidence). The disease is more common among the urban than among the rural population in Yugoslavia; the comparison of mortality due to MS revealed no appreciable differences.

Adult↗
PubMed1983

[Principles and problems in the epidemiology of multiple sclerosis].

The problems of epidemiological studies in multiple sclerosis (MS) concern: the (1.) difficulties of diagnostics, the (2.) development and heterogeneity of the disease (manifestation and forms of course), the (3.) peculiarities of ascertainment of patients, the (4.) respective area of investigation (geographical location and size) and the (5.) population (including genetics and sociologic-economical factors). Further components, influencing incidence, prevalence and mortality, were exposed. As for the area of Rostock the onset of illness amounts to 30.9 ( +/- 8.9) years on an average; an incidence rate of 2.9 and prevalence rate of 60.4 (per 100 000 inhibitants) could be determined. Beside informations about the number of cases treated clinically in the several districts (with downward trend from North to South-East) there were given hypothetical data regarding the incidence and prevalence of MS in the GDR.

Adolescent↗