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Biomedical subjects

F Busch

Publications and source records attributed to F Busch.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Treatment and socioeconomic consequences of skiing injuries in the County of Vejle during the 1986/1987 season].

In a prospective study conducted in the County of Vejle in the skiing-season 1986/1987, the hospitals were contacted by 129 persons who had skiing-injuries. Forty-one patients were primarily treated abroad and 35 patients were primarily examined or treated in Denmark after their return. Fifty-three patients who were injured in Denmark were primarily examined or treated in the casualty ward. The injuries the most often seen were knee and thumb-injuries. Twenty-three operations were undertaken, 15 on knees, and five on thumbs. A total of 139 bed-days were registered, 114 for injuries abroad and 25 for Danish injuries. Fifty-nine injured persons lost 1,481 days on account of sickness. The yearly nationwide costs for the health services in connection with skiing-injuries are calculated to be 9.2 million kroner (approximately 760,000 pounds). The expenses for loss from production are calculated to be 8.6 million kroner (approximately 716,000 pounds).

Athletic Injuries↗
PubMed1989

Antitumor activity in vitro in chronic myelogenous leukaemia revealed after treating peripheral cells with cytosine arabinoside.

Cytosine arabinoside (Ara-C) treatment of peripheral blood mononuclear cells from 12/12 chronic-phase chronic myelogenous leukaemia (CML) patients revealed a proliferative response stimulated by their untreated leukaemic cells. Specific recognition of tumour cells by patients' normal lymphocytes was suggested by the finding that cells of siblings genotypically identical for human leukocyte antigen caused no stimulation. Lymphocytes thus stimulated by tumour cells from one of these patients were cloned by limiting dilution and tested for antileukaemic effects in cytotoxicity and proliferation assays. Cytotoxic lines were isolated that killed autologous CML targets but only a limited number of allogeneic fresh leukaemias or cell lines. These results show that anti-leukaemia effectors can be isolated from chronic-phase CML patients and suggest their potential application in adoptive immunotherapy.

Antigens, Differentiation↗
PubMed1989

Drug abuse in schizophrenia and bipolar disorder.

The incidence and type of drug abuse for 50 male schizophrenic patients and 60 male and female bipolar, manic patients were determined. Fifty percent of schizophrenic patients and 25% of bipolar patients abused one or more drugs. Alcohol, cannabis, and cocaine accounted for 82% of the drug abuse.

Adult↗
PubMed1989

The compulsion to repeat in action: a developmental perspective.

The compulsion to repeat in action is seen as being a particular way of thinking that is characteristic of the time when neurosis is formed. This type of thinking has been abundantly studied by Piaget, and is seen as a consequence of the development of more complex thought from action roots. Piaget has labelled this thinking as pre-operational, and it is seen as occurring between the ages of eighteen months and 7 years. Descriptively, it is best characterized as action-thoughts rather than as action. In the area of their neurosis, action-thoughts are a communication by the patient in the only way they can, and are consistent with Freud's earliest description of the compulsion to repeat. Finally, action-thoughts are seen as an ego restriction in the areas of a patient's conflicts.

Acting Out↗
PubMed1988

Division of human helper T cells into two sets on the basis of the induction of anti-tumor cytotoxicity by phorbol ester and calcium ionophore.

Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their proliferative response or lack of it to TPA/Io. Nonresponders could not be converted to responder status by addition of interleukin (IL) 1 or indomethacin to the cultures. Responder status did not correlate with any of the following properties of the clones: originating donor, recognitive specificity, B cell helper activity, proliferative response to IL 2 or 4, lymphokine secretory capacity or density of expression of antigen receptors, CD4 or HLA class II molecules. Responder status did, however, correlate with the ability of TPA/Io to induce major histocompatibility complex-unrestricted cytolytic activity directed towards natural killer-resistant tumor cells. These results divide human helper cells into two types on the basis of induction of anti-tumor cytotoxicity.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1980

Studies on the cosubstrate site of protease solubilized NADPH-cytochrome P450 reductase.

Modification of the protease solubilized NADPH-cytochrome P450 reductase (= NADPH-cytochrome c reductase) at the critical SH group in the cosubstrate binding site affects KmNADPH but not V for the cytochrome c reduction. The increase of KmNADPH is dependent on the size and the charge of the substituent introduced. Substitution of the cosubstrate site SH by the CN-, S2O3- and the (N-ethyl) succinimido group effects a 3-, 7- and 23-fold increase of KmNADPH, respectively. The critical SH group in the NADPH binding region can be specifically radiolabeled by N-ethyl (2,3-14C) maleimide after preincubation of the reductase with unlabeled NEM in the presence of 1 mM NADP+. The selective reaction at the essential cysteine in the cosubstrate site is demonstrated by peptide mapping of the thermolytic digest and urea SDS gel electrophoresis of the cyanogen bromide fragments of the reductase. Protease solubilized NADPH-cytochrome P450 reductase is inactivated by reagents directed to histidine, arginine and lysine residues. NADP (H) (1 mM) and 2'-AMP (1 mM) give effective protection only for the reaction of 1,2-cyclohexanedione (12 mM). The functional role of the basic amino acid residues for the cosubstrate binding by the NADPH-cytochrome P450 reductase cannot be established therefore by the modification experiments described. The number of NADPH binding sites in the NADPH-cytochrome P450 reductase is determined to one site/mol reductase by titration of the enzyme with NADP+ monitored by CD-spectroscopy.

Amino Acids↗
PubMed1979

[Animal experiments with 99mTc-diethyl-HIDA in acute complete bile duct occlusion (author's transl)].

In order to establish whether a complete obstructive jaundice can abolish the accumulation of diethyl-HIDA (EHIDA) in the liver parenchyma, the common bile duct was ligated in 14 mongrel dogs. Before as well as at regular intervals after ligature of the common bile duct, a sequence scintigraphy was performed with 2 mCi 99mTc-EHIDA. For evaluation, time-activity curves (Tmax, T1/2), and analogue scintigrams as well as laboratory parameters were used for assessment. Up to seven weeks after ligation of the common bile duct, there was a marked accumulation of EHIDA in the liver parenchyma. The relative liver uptake (liver/background ratio) fell from 8.9 to 2.7, whereas conversely the cholestasis indicators aP and bilirubine rose markedly. Tmax did not show any significant alterations, whereas T1/2 was prolonged from about one week after ligation. Because of the duct ligation, there was no excretion of activity into the intestines. Immediately after ligation of the common bile duct, the gallbladder was shown up as a "hot" area in which the majority of the applied activity appeared from about one hour p.i. Begining with the fifth to the seventh day after ligation, the gallbladder was seen as a "cold" area in the liver paraenchyma. Bilirubine and aP were raised by about 50 times the initial value. With longer lasting cholestasis, the scintigram no longer altered whereas bilirubine and aP rose further. Histological examination after ligation for more than five weeks showed slight alterations as a whole. Gamma-GT and in particular GPT were likewise slightly raised compared to bilirubine and aP. The conclusion was drawn from this that the good accumulation of EHIDA in the liver parenchyma which is to be observed without exception even in cholestasis lasting for several weeks could be explained by a relatively slight hepatocellular damage. Only when there is a consecutive parenchymal damage in extrahepatic jaundice, accumulation of EHIDA in the liver can be abolished.

Acute Disease↗
PubMed1977

Theme and variation in the development of the first transitional object.

In our research we have been attempting to elucidate the phenomenon we have labelled the 'first transitional object'. In this paper we have focused primarily on some dimensions along which the child can vary in his use of the first transitional object. We have pointed to the fact that some infants first come in contact with the 'blanket' at the age of three months, and this seems to be a critical time period for regular contact with the first transitional object. While there are variations in the child's attachment to the first transitional object from the very beginning, age two appears to be a crucial time when the intensity of the child's attachment to the 'blanket' becomes established. Most children seem to give up the first transitional object between five and six years of age, and an example of the disruption of this process was presented. An attempt was made to put these findings within a developmental context, while other variables which affect the fate of the first transitional object were also explored.

Age Factors↗
PubMed1970

[A patchholder].

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Cardiac Surgical Procedures↗