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Biomedical subjects

F Butler

Publications and source records attributed to F Butler.

At least 55 records · Page 3Linked to original sources
PubMed1990

Disposition of a murine monoclonal antibody vinca conjugate (KS1/4-DAVLB) in patients with adenocarcinomas.

The pharmacokinetics of a murine monoclonal antibody vinca conjugate (KS1/4-DAVLB) was investigated in 13 patients with adenocarcinomas who received single intravenous doses ranging from 40 to 250 mg/m2 and in three patients who were administered 1.5 mg/kg every 48 to 72 hours for up to 15 doses. Five patients in the single-dose study also received 100 microCi of [3H]-KS1/4-DAVLB. Overall mean values for the pharmacokinetic variables were as follows: elimination half-life, 31.5 hours; distribution volume, 4.43 L; and clearance, 0.09 L/hr. KS1/4-DAVLB demonstrated linear elimination kinetics in both the single- and multiple-dose studies. Significant concentrations of KS1/4-DAVLB were noted in a pleural effusion. Ten percent of the radioactive dose was recovered in the urine and 20% in the feces over a 5-day period. Small molecular weight vinca species were detected in the feces but not in the serum.

Adenocarcinoma↗
PubMed1989

Ultrasound findings in carcinoma of the gallbladder.

The ultrasound findings in 5 cases of primary carcinoma of the gallbladder are described. A mass protruding into or replacing the gallbladder or abnormal gallbladder wall were found in all cases. Four of the patients had gallstones and a dilated biliary tree. With careful technique in evaluation of the gallbladder wall in patients with gallstones early carcinoma of the gallbladder may be detected with greater frequency.

Aged↗