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F C Berthoux

Publications and source records attributed to F C Berthoux.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Monitoring of renal grafts. Value of the determination of serum neopterin and neopterin versus creatinine ratio].

In a longitudinal study, 53 renal allograft recipients were investigated for changes in serum creatinine and neopterin levels and in the neopterin/creatinine (N/C) ratio which makes it possible to disregard the glomerular filtration level. The patients were divided into 5 groups according to their clinical situation: stability, acute renal failure due to acute tubular necrosis, acute graft rejection, bacterial or viral infection and cyclosporin overdosage. Only N/C discriminated between these situations, being normal (less than 200.10(-6) in groups 1 and 2, significantly elevated in groups 3 and 4 and low in group 5. The highest N/C value was observed in patients with primary cytomegalovirus infection. It is concluded that the N/C ratio is a good biochemical parameter to be used in the follow-up of renal allograft recipients.

Adult↗
PubMed1989

[Immunopathology of glomerulonephritis with mesangial IgA deposits].

IgA nephropathy is the most frequent type of glomerulonephritis in France. Its definition is on renal pathology. Mesangial IgA deposits are dimeric or polymeric and probably from secretory origin. Circulating IgA molecules correspond to immune complexes with unknown antigens. The IgA subclass remains still controversial: exclusive IgA1 versus IgA1 and IgA2. The pathogenesis of the disease is based on an immune defect specific of the secretory IgA system and eventually of the serum IgA system. The human disease can be experimentally reproduced. Nevertheless, numerous unknown explanations persist in this disease.

Animals↗
PubMed1989

[Arterial hypertension with renin hypersecretion secondary to pyelo-ureteral syndrome. Cure after corrective surgery].

In a 22 years old woman with recent hypertension, a timed intravenous pyelogram revealed an asymptomatic obstructive ureteropelvic junction. Preoperative renal vein catheterization demonstrated excessive renin release from the diseased kidney and low release from the other one, suggesting that corrective ureteral surgery should return blood pressure to normal levels. Moderately impaired glomerular filtration rate improved after surgery as a consequence of suppressed hydronephrosis and bilateral renal ischemia. Thus we conclude that in young people, asymptomatic unilateral hydronephrosis can lead to hypertension and renal failure like renal artery stenosis. In the other cases of urinary flow obstruction, secondary hypertension remains to be explained by both inappropriate production of renin and water chronic retention.

Adult↗
PubMed1988

Incidence of cytomegalovirus infections in renal transplant patients treated with conventional or cyclosporin therapy.

The incidence and severity of cytomegalovirus (CMV) infection was examined in groups of consecutive renal transplant patients: group A (50 patients) transplanted from August 1984 to October 1985 received cyclosporin (from the day of transplantation) and steroid therapy; group B (50 patients) transplanted between June and July 1984 received conventional therapy (azathioprine and steroids, and antilymphocyte globulin for 14 days). In groups A and B there were respectively 5 (10%) and 14 (28%) seronegative patients prior to transplantation (CMV antibody titre less than 128 by ELISA); the overall incidence of CMV was 38% vs 74% (P less than 0.001); the incidence of primary infection was 0% (0 of 5) vs 36% (5 of 14) (NS); the incidence of secondary infection was 42% (19 of 45) vs 89% (32 of 36) (P less than 0.00001); and the total incidence of symptomatic infection was 10% vs 26% (P = 0.04). Thus we conclude that initial cyclosporin therapy leads to a reduction in CMV infection.

Antilymphocyte Serum↗
PubMed1988

Long-term prognosis in malignant or accelerated hypertension.

In 51 consecutive patients with malignant hypertension collected from 1976 to 1981 we have analysed patient and kidney survival at 5 years and at last follow-up. The patients were 41 men, 10 women, mean age 53 years, with a stage III (63%) or stage IV (27%) fundi and a diastolic blood pressure (BP) greater than 130 mmHg. The hypertension was primary in 26, renovascular in 17 and secondary to bilateral nephropathy in eight. At 5-years follow-up, the patient and kidney survival rates were respectively 72.5% and 47%. At last follow-up, 18 patients had died (35%) and 18 additional patients require dialysis (renal death = 70%). The principal causes of death related to terminal renal failure and/or dialysis. Initial involvement of heart (27%) and brain (35%) led to a few more deaths. Blood pressure control reduced consequences for the heart and brain but not for the kidney. Patients at higher risk are those with serum creatinine greater than 200 mumol/l on admission.

Adult↗
PubMed1988

[Evaluation of surgical renal revascularization in renovascular arterial hypertension. Measurement by 99m Tc DTPA scintigraphy].

The effects of surgical renal revascularization on both hypertension and kidney function was assessed in 16 patients with renovascular hypertension (14 unilateral). We have taken a special interest to the split renal function studied with DTPA renogram. The function of the operated kidney was improved in 9 patients and not improved (worsened or unchanged) in 7. Hypertension was cured in 25% and improved in 56% of the patients, without correlation with split renal function outcome.

Adult↗
PubMed1987

[Isolated dissection of the renal artery treated by conservative surgery in 3 patients].

We reported 3 cases of male patients with isolated dissecting aneurysm of the renal artery. The clinical presentation included lumbar pain followed by hypertension (malignant in 2 cases) in the next 3 months. These three patients have underwent surgical renal artery repair. At maximal follow-up (4, 5, 11 years after surgery), the blood pressure was normalized in these 3 patients (with one antihypertensive drug in 2) and the renal function remained stable.

Adult↗
PubMed1987

Live poliovirus vaccine in patients with chronic glomerulonephritis: effects on renal function and specific antibody response.

Twenty-one patients with chronic glomerulonephritis (GN) (5 with renal failure) received three doses of live trivalent poliovirus vaccine administered orally. The effect of the polio vaccination on the renal function and the titers of antibodies to poliovirus were studied. No significant consequence was observed in renal disease. Before vaccination, titers of poliovirus type 1 and 3 antibodies were significantly decreased as compared to healthy adult subjects. After vaccination, the patients exhibited a significant rise in poliovirus antibody titers for the three serotypes, although some of them failed to develop a fourfold or greater antibody rise to at least one of the three serotypes, especially in the group of patients with renal failure. These results indicate that live poliovirus vaccination is not deleterious in patients with GN and can provide a good protection.

Adolescent↗
PubMed1986

IgA mesangial deposits in C3H/HeJ mice after oral immunization with ferritin or bovine serum albumin.

In order to study an experimental model of IgA nephropathy, C3H/HeJ mice which are high IgA responders were strongly immunized orally with ferritin and compared to syngeneic C3H/eB. C3H/HeJ exhibited a significant increase of total IgA level in the serum and of IgA deposits in the mesangium. However the low level of IgA antibody to ferritin detected in the serum and the unsuccessful search for ferritin and antibody to ferritin in the glomeruli suggest that strong oral immunization of C3H/HeJ mice leads to high level of non specific IgA in the serum and deposition of IgA in the kidney.

Animals↗
PubMed1986

[Renal transplantation and pregnancy. Apropos of a case].

A cystic disease of the medulla is found in a young women at the 5th month of her first pregnancy and entails the death of the foetus in utero. The chronic renal insufficiency rapidly worsens and necessitates periodic hemodialysis. Renal transplantation is carried out from a brother with identical HLA. Two years later the graft is functioning well enough to permit another pregnancy. It proceeds without accompanying nephropathy. A caesarean operation carried out 36 weeks after amenorrhea gives birth to a girl who presents normal psychomotor development at two years of age. The authors consider the influence of pregnancy on the functioning of the kidney graft and the criteria permitting pregnancy after a renal transplant. They discuss the consequences of a renal transplant on the progress of the pregnancy and delivery. Finally, they study the effects of immunosuppressive treatment on the child in the short and long term.

Adult↗
PubMed1985

IgA mesangial deposits in C3H/HeJ mice after oral immunisation.

In order to develop an experimental IgA nephropathy, C3H/HeJ mice, high producers of IgA, were strongly immunised orally by ferritin and compared to C3H/eB mice. After immunisation, serum IgA and IgG titres increased significantly only in C3H/HeJ mice. Specific antiferritin antibody could be detected in the serum. Mesangial IgA deposits were present in most of C3H/HeJ mice after immunisation and were significantly higher than in C3H/eB mice. No ferritin deposits could be detected in the kidney. No clinical manifestation appeared in these animals.

Animals↗
PubMed1984

Immunogenetics and immunopathology of human primary membranous glomerulonephritis: HLA-A, B, DR antigens; functional activity of splenic macrophage Fc-receptors and peripheral blood T-lymphocyte subpopulations.

In most of our patients with idiopathic membranous nephritis (MGN), we have studied the HLA-A, B, DR phenotype, the clearance of anti Rhesus D coated-51 Cr-labeled-autologous erythrocytes, and the peripheral blood T-lymphocyte subpopulations as ascertained by monoclonal antibodies (OKT3, OKT4, OKT8). The frequency of HLA-B8 antigen is 57.14% in 28 primary MGN versus 14.4% in 104 local controls (Pc less than 0.00018). The frequency of HLA-DR3 antigen is 65.38% in 26 primary MGN patients versus 20.27% in 74 local control individuals (Pc less than 0.00008). The half-life of sensitized erythrocytes is 37.30 +/- 9.55 min in 10 controls, 1963 min and 1601 min in 2 splenectomized controls, 12 min in a patient with hypersplenism, and 67.05 +/- 69.64 min in 18 idiopathic MGN patients respectively. The half-life is significantly prolonged in 6 out of 18 MGN patients. This prolongation correlates with exacerbation of the disease while normal values are obtained with remission. The OKT3 positive subpopulation (total T-lymphocytes) is 63.77 +/- 10.37% in 31 controls versus 53.74 +/- 13.81% in 22 MGN (P less than 0.002). The OKT4 positive subpopulation (helper T-cells) is 37.90 +/- 8.21% in controls versus 32.79 +/- 10.89% in MGN (P less than 0.03). The OKT8 positive subpopulation (suppressor T-cells) is 21.60 +/- 5.28% versus 20.03 +/- 5.76% respectively. The OKT4/OKT8 ratio is 1.85 +/- 0.58 in controls versus 1.74 +/- 0.69 in MGN. During exacerbation, the T-lymphocyte subset fractions are normal, whereas OKT3 and OKT4 are decreased during remission. MGN is a strongly HLA-linked disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗