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Biomedical subjects

F C Hoskin

Publications and source records attributed to F C Hoskin.

At least 37 records · Page 2Linked to original sources
PubMed1971

Diisopropylphosphorofluoridate and Tabun: enzymatic hydrolysis and nerve function.

Squid nerve contains an enzyme that hydrolyzes the nerve gas Tabun at about one-tenth the rate it hydrolyzes diisopropylphosphorofluoridate (DFP), and at about one-third to one-fourth the rate it hydrolyzes Sarin and Soman. Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid-and water-soluble, and penetrates readily into the squid giant axon in its inhibitory form. The failure of Tabun to block or markedly decrease the conducted action potential in the squid axon makes it likely that the blocking of conduction caused by DFP is probably not due to inhibition of acetylcholinesterase. Sub-strate specificity with regard to organophosphate metabolism by squid enzyme has possible implications for the disposal and detoxication of nerve gases in the ocean.

Action Potentials↗
PubMed1967

Penetration of an organphosphorus compound into squid axon and its effects on metabolism and function.

The tertiary analogute of phospholine, namely, (C(2)H(5)O)(2)P(O)SCH(2)CH(2)N(CH(3))(2), is a potent, irreversible inhibitor of cholinesterase which, when externally applied to the sqluid giant axon, readily penetrates in its inhibitory form into the axoplasm. However, even a 10(-2) molar solution of this compound does not block axonal conduction unless the axon is first treated with a low concentration of venom from the cottonmouth moccasin. The question of the activity of acetylcholinesterase in these axons is considered, and the possibility of subcellular permeability barriers for indivisual components of the excitable membrane is discussed.

Acetylcholinesterase↗