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Biomedical subjects

F C Lee

Publications and source records attributed to F C Lee.

At least 37 records · Page 2Linked to original sources
PubMed1988

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.

Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Effects of Panax ginseng on blood alcohol clearance in man.

1. Fourteen healthy male volunteers were studied to assess the effects of Panax ginseng on blood alcohol clearance, utilizing each subject as his own control. 2. At 40 min after the last drink, the blood alcohol level in the test group receiving ginseng extract (3 g/65 kg body weight) along with alcohol (72 g/65 kg body weight) was about 35% lower than their control values. 3. When the blood alcohol level was compared on individual bases, alcohol concentrations in 10 out of 14 test subjects ranged from 32 to 51% lower than their control values. 4. These results demonstrate that P. ginseng extract enhances blood alcohol clearance in man.

Adult↗
PubMed1987

Effects of Panax ginseng extract on the benzo(a)pyrene metabolizing enzyme system.

Ethanol extract of Panax ginseng C. A. Meyer, which has been used for centuries as a tonic in Asian countries, exhibited a selective induction of epoxide hydratase and cytosolic glutathione transferase activity without the concurrent induction of aryl hydrocarbon hydroxylase activity. Thus, Panax ginseng appears to have the potential to alter the metabolic patterns of benzo(a)pyrene and its reactive metabolites.

Animals↗
PubMed1986

Fat embolism syndrome with total hip replacement.

Two cases of fulminant fat embolism syndrome that were fatal are reported as complications of total hip replacement. The major clinical features were severe hypotension and cardiac arrest in one case and postoperative coma in the other case. Both patients had severe acute respiratory failure that resulted from pulmonary oedema.

Aged↗
PubMed1984

Localization of the menaquinone-0 alkylating enzyme in the smooth reticulum of chicken liver microsomes.

The alkylation of menaquinone-0 to menaquinones occurs in the microsomal fraction of chick and rat liver. Subfractionation of chick microsomes into smooth and rough reticulum was achieved by density gradient centrifugation. The alkylation enzyme was localized in the smooth reticulum with an activity of 155 pmol/mg per h, about 50-fold greater than that in the rough reticulum. The membrane-bound alkylating enzyme system requires reduced menaquinone-0 and is phospholipid-dependent.

Alkyl and Aryl Transferases↗