Chronic toxicity studies of crude organic chemical pollutants, illustrated by studies with Aroclor 1254.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to F C Lo.
Explore the source record for details and available documents.
Aroclor 1254 was fed to female and male rats daily for 9 weeks at a dose of 6.4 mg/kg in their drinking water. Control animals received plain tap water plus the emulsified (0.15% Tween 80). Elevated mixed function oxidase (MFO) activity appeared to be due to 2,4,5,2',4',5'- and 2,4,5,2'3'4'-hexachlorobiphenyls, since only these compounds were present to any degree in the tissues of the animals when MFO activity persisted after termination of exposure. The placenta apparently is an effective barrier to PCB transfer.
Except for pure synthetic polychlorinated biphenyl (PCB), estimation methods of PCB by thin-layer and gas chromatography with electron capture detection give comparable results. Both give a good estimate of the true mass of a biologically modified residue, but where mostly hexachlorobiphenyls and above make up the residue, the estimate will be up to 50% too high. The Coulson detector does not, in our hands, yield comparable results with modified residues: the reason for this difference is not clear at present.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.