Biomedical subjects

F C Ninger

Publications and source records attributed to F C Ninger.

3 recordsLinked to original sources

PubMed1977

Rapid determination of nitroglycerin volatility using thermogravimetric analysis.

The effect of selected tablet components on the volatility of nitroglycerin from compressed sublingual tablets was studied by thermogravimetric analysis. The results, confirmed by chemical analyses, showed that nitroglycerin volatility is significantly reduced by the use of povidone USP and microcrystalline cellulose NF in tablet formulations. In general, the stabilizing effect of these materials was dependent on the presence and the concentration of each other. These studies demonstrated the utility of thermogravimetric analysis as a rapid and reliable means of screening nitroglycerin formulations for stability purposes.

Cellulose↗

PubMed1976

Calibration of a horizontal pendulum-type tablet breaking strength tester.

A rapid, simplified method of checking the calibration of a new motorized pendulum type of tablet hardness tester and the accuracy and precision of three testers were determined. Two force gauges were calibrated, and both gauges were used by two operators to determine the accuracy of the new testers. The calibration method using the force gauge was reliable for checking the accuracy. The results show the various new testers to be in calibration and to give reproducible results.

Hardness Tests↗

PubMed1976

Stabilized compressed nitroglycerin tablets.

A stabilized compressed nitroglycerin tablet, containing microocrystalline cellulose NF and providone NF as stabilizing agents, was formulated. Bioavailability and physical tests were conducted on the compressed tablet and two leading brands of molded tablets. There was no difference in the mean pulse rate between a molded tablet formulation and the compressed tablet in a crossover study using 10 human volunteers and three tablet strengths, 0.3, 0.4, and 0.6 mg. The compressed tablet was most uniform when tested according to the USP method for weight variation and content uniformity. Various tests for nitroglycerin loss due to volatility, i.e., open dish test, thermogravimetric analysis, and simulated in-use test, all indicated that the stabilized compressed tablet was substantially more stable than partially stabilized or unstabilized molded tablets.

Adult↗