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F Cabañas

Publications and source records attributed to F Cabañas.

22 records · Page 2Linked to original sources
PubMedDate not supplied

Natural history of ventricular dilatation in preterm infants: prognostic significance.

Cerebral ultrasounds were prospectively performed in 100 infants weighing 1,500 gm or less in order to evaluate the prognostic significance of ventricular dilatations and their associated findings. There was no difference in the incidence of ventricular dilatation (24%) between patients with or without periventricular hemorrhage (PVH). Although patients with PVH developed ventricular dilatation significantly earlier than infants without PVH, no differences were observed in severity, location, head circumference growth, or intracranial pressure between the groups. Ventricular dilatation was statistically related to PVH grade III and PVH with parenchymal involvement; grades moderate-to-severe of periventricular echogenicity; and cystic periventricular leukomalacia (PVL). Ventricular dilatation persisted longer than 6 weeks in 61% of infants and had irregular margins in 62%. The latter were significantly related to cystic PVL. Seventy-seven of 100 infants examined were followed until 20 months corrected age. Ventricular dilatation mainly when persistent and with irregular margins was associated with handicaps. We conclude that ventricular dilatation is frequent in very low-birth weight infants. Furthermore, its occurrence may be independent of PVH. Persistent ventricular dilatation with irregular margins, even in its mild forms, suggests a parenchymal lesion and guarded prognosis.

Brain Damage, Chronic↗
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[Non-invasive monitoring of cerebral hemodynamics in the newborn].

INTRODUCTION AND DEVELOPMENT: The regulation of cerebral blood flow (CBF) is a determinant factor amongst the mechanisms involved in the development of neonatal brain lesions. Therefore it has been the main objective of many investigators in recent decades, seeking reliable techniques for measurement of cerebral haemodynamic parameters. However, the use of different techniques to assess brain haemodynamics has been limited by various factors including: harmlessness of the technique, its ease of use and accuracy of measurement. In this paper we aim to show how, using these techniques, together with sufficient understanding of neonatal pathophysiology, we can obtain better understanding of antenatal and perinatal factors responsible for cerebral damage, and the effect of this lesion on development. Besides using these findings to prevent specific disorders, we will obtain the advantage of an appropriate medical and neurosurgical treatment, with lower risk of neurological sequelae.

Blood Flow Velocity↗
PubMedDate not supplied

[Cerebellar hypoplasia in the newborn: association with respiratory control disorders and mental retardation].

Cerebellum malformations are frequently diagnosed since the advent of the neuroradiological studies (computed tomography, magnetic resonance imaging and ultrasonography). Cerebellar hypoplasia is found in association with a wide variety of neurologic and systemic disorders. Clinical picture in newborn may be different than in other periods of life. Two characteristics are interesting in neonatal period: their relation with abnormal respiratory control and mental retardation. The pathophysiology of cerebellar hypoplasia is uncertain, however experimental studies suggest than an abnormality of the Bergman glia may lead to the observed granulle cell layer deficiency in this malformation. It is tempting to speculate that a similar migrational abnormality in the cerebrum accounts for the intellectual impairment seen in some affected patients. Respiration is a complex neural function requiring precise coordination of numerous neural circuits. Cerebellar hypoplasia may be important in the pathogenetic mechanism of abnormal respiratory control due to cerebellar respiratory control disturbance. Also diaphragmatic dysfunction may occur in association with cerebellar atrophy. We report two newborns with cerebellar hypoplasia (vermis and hemispheres) associated with central respiratory and neurological dysfunction, and mental retardation.

Body Weight↗