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F Caire

Publications and source records attributed to F Caire.

5 recordsLinked to original sources
PubMed2006

[Subthalamic deep brain stimulation for severe idiopathic Parkinson's disease. Location study of the effective contacts].

The subthalamic nucleus (STN) is the main target of deep brain stimulation (DBS) treatment for severe idiopathic Parkinson's disease. But there is still no clear information on the location of the effective contacts (used during the chronic phase of stimulation). Our aim was to assess the anatomical structures of the subthalamic area (STA) involved during chronic DBS. Ten patients successfully treated were included. The surgical procedure was based on direct STN targeting (stereotactic MRI based) pondered by the acute effects of intraoperative stimulation. We used a formaldehyde-fixed human specimen to compare by matching MRI images obtained at 1.5 Tesla (performed in clinical stereotactic conditions) and at very high field at 4.7 Tesla. This allowed accurate analysis of the anatomy of the STA and retrospective precision of the location of the center of effective contacts which were located within the STN in 4 patients, at the interface between the STN and the ZI and/or FF in 13, at the interface between ZI and FF in 2 and between the STN and the substantia nigra in one. These results were consistent with the literature, revealing the implication of neighboring structures, especially the zona incerta and Forel's Field, in the clinical benefit.

Aged↗
PubMed2006

[Venous embolization of dural arterio-venous fistulas. Transcranial approach under neuronavigation].

OBJECT: Transvenous embolization is an effective treatment for dural arterio-venous fistulas. In the event of dural sinus thrombosis, embolization can be performed by direct puncture via craniectomy. We report our experience with transcranial venous embolization in two patients. METHODS: Two patients underwent transcranial venous embolization of a type-III dural arterio-venous fistula of the transverse sinus. The craniectomy was performed with neuronavigation assistance. RESULTS: The surgical approach consisted in a minimal exposure of the sinus with a drill. Neuronavigation allowed accurate placement of the craniectomy. The endovascular treatment was performed in a second stage, enabling complete and stable occlusion of the fistula in both patients. CONCLUSION: This combined treatment of dural AVFs associating craniectomy and transcranial puncture of the sinus is simple and efficient when retrograde navigation through the internal jugular vein cannot be achieved. Neuronavigation is helpful in accurately positioning the craniectomy.

Aged↗
PubMed2006

Platelet-activating factor and human meningiomas.

Meningiomas are common primary intracranial tumours. Platelet-activating factor (PAF) is an inflammatory and angiogenic lipid mediator involved in several types of cancer. The presence of PAF receptor (PAF-R) transcripts, the levels of PAF, the phospholipase A2 activity (PLA2, the enzymatic activity implicated in PAF formation) and the PAF acetylhydrolase activity (AHA, the PAF degrading enzyme) were investigated in 49 human meningiomas. PAF-R transcripts, PAF, PLA2 and AHA were detected in meningiomas. However, their levels did not correlate with biological parameters such as the tumour grade, the presence of associated oedema, necrosis, mitotic index as well as intensity of the neovascularization and chronic inflammatory response. In conclusion, PAF is present in meningiomas where it might act on tumour growth by altering the local angiogenic and/or cytokine networks as previously suggested for human breast and colorectal cancer.

1-Alkyl-2-acetylglycerophosphocholine Esterase↗
PubMed2004

[Self-assessment for neurosurgery residents by script concordance test (SCT). The process of test elaboration].

BACKGROUND: The script concordance test (SCT) is a new tool to assess clinical reasoning in a context of uncertainty. It was chosen for computer-based self-assessment training for neurosurgery residents. PURPOSE: The aim of this work is to describe the construction of a first series of questions and provide teachers practical information needed to build a SCT. METHOD: The theorical background of the SCT is explained. We review the steps we followed when writing of a series of more than two hundred questions. RESULTS: We present the different steps of our work, including writing clinical cases, validation of questions and elaboration of scoring systems. We explain the main difficulties we encountered. CONCLUSION: The script concordance test is an interesting easy-to-construct assessment tool useful for evaluating clinical competence. This work summarizes our experience in building a SCT, which should be helpful for teachers interested in this new assessment tool, especially in neurosurgery.

Clinical Competence↗