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Biomedical subjects

F Camacho Martínez

Publications and source records attributed to F Camacho Martínez.

At least 19 recordsLinked to original sources

Frontal fibrosing alopecia: a survey in 16 patients.

BACKGROUND: Postmenopausal frontal fibrosing alopecia (PFFA) was described by Kossard et al. as a progressive recession of the frontal hairline affecting particularly postmenopausal women. Further cases of PFFA have been reported to date, all of them considering it as a variant of lichen planopilaris on the basis of its clinical, histological and immunohistochemical features. OBJECTIVE: To describe clinical features, and response to treatment of 16 cases of frontal fibrosing alopecia diagnosed at our department in the last 6 years. METHODS: In addition to clinical data, biopsies and laboratory tests (antinuclear antibodies, sex hormones, thyroid hormones) were performed in order to rule out other causes of scarring alopecia. Patients were treated with intralesional corticosteroids, finasteride, and minoxidil, depending on the stage of the disease and association to androgenetic alopecia. RESULTS: All patients presented progressive alopecia localized to the frontal and temporal hairlines. Eight patients (50%) had loss of eyebrows, and six patients (37.5%) had axillar alopecia. Ages ranged from 45 to 79. Three of these women were premenopausal. Androgenetic alopecia was evident in seven patients (43.8%). All patients biopsied showed perifollicular lymphocitic infiltrate with lamelar fibrosis limited to the upper portions of the follicle. The progression of the condition stopped in most patients after a variable period on treatment. When treatment was abandoned the alopecia progressed to 'clown alopecia' appearance. DISCUSSION: Cases of Kossard's type scarring alopecia affecting premenopausal women made us consider that this condition is not exclusive of postmenopausal women. Differential diagnosis should take into account conditions like female androgenetic alopecia, fibrosing alopecia in a pattern distribution, alopecia areata, and chronic lupus erythematosus. Except for the pattern of alopecia, lichen planopilaris and frontal fibrosing alopecia are indistinguishable, thus the latter is included as a variant of lichen planopilaris. Although the disease tends to spontaneous stabilization, intralesional and topical corticosteroids, and anti-androgens may stop the progression of the disease and improve the female androgenetic alopecia that usually is associated to FFA.

Aged↗

[Ofujis papuloerythroderma. Presentation of 3 cases and review of its concept and etiology].

Ofuji's papuloerythroderma is not a specific clinical entity, but a concequence of numerous inflammatory dermatoses and neoplasms. Some authors advocate that it is possible to find this erupcion in elderly patients with different types of erythroderma of known or unknown origin. It is necessary to recognize this condition since these patients can develop a lymphoma in the future. In this article three atopic patients are described with clinical lesions of papuloerythroderma respecting the cutaneous folds, with eosinophilia, increase of the IgE levels and histological characteristics of atopic eczema. We think that atopic dermatitis should be considered in the etiologic study of patients with papuloerythroderma.

Aged↗

[Study of urethritis in males using Papanicolaou smear].

Sexual pathogens, cell types and morphologic alterations of urethral epithelial cells were investigated by means of the Papanicolaou smear in 110 heterosexual men. Seventy-five patients with urethritis were included: 17 (22.6%) with gonococcal urethritis (GU) and 58 (77.3%) with non-gonococcal urethritis (NGU). Thirty-five males without symptoms or signs of urethritis comprised the control group. An increase in epithelial cell dissociation was observed in patients with urethritis. Non-specific inflammatory changes were statistically more common in patients with urethritis than in controls, and more severe in GU (65%) than in NGU (15.5%). Nuclear atypia was a common finding (43.5%) in infections due to C. trachomatis. Mucus was associated with the presence of urethritis although no differences regarding etiology were found. No polimorphonuclear neutrophils were observed in the exudate of three patients (5%) with NGU. There was a statistically significant presence of lymphocytes in patients with urethritis, particularly in GU (45%), more frequent than in NGU (15.5%). Erythrocytes were also significantly more frequent in urethritis, with a greater proportion in GU (94%) than in NGU (64%). Plasma cells, eosinophils, and histiocytes were only observed in a few patients with urethritis. The Papanicolaou smear had a sensitivity of 47% and a specificity of 90% in Chlamydia trachomatis infections.

Humans↗

[Oral lesions in toxic epidermal necrolysis].

In the oral mucosa it can be observed lesion produced by general disease. These, in some occasions help to obtained diagnosis, but in other it makes a lot of difficulties. We observed a patient with a toxic epidermal necrosis. His first signs were herpes oral lesions. We made a differential diagnosis with other dermatological process, and examined the possibilities in obtaining a diagnosis and the validity of the analytical data.

Adult↗

[Congenital solitary fibromatosis].

Infantile myofibromatosis is included in fibrous proliferations of infancy, processes with specific clinic, histology, and evolution, that are characterized by nodules in the skin, bones, and viscera. It's prognosis is varied, depending on whether it is manifested in the solitary or multicentric form. We describe a patient with congenital solitary myofibromatosis.

Female↗

[Effects of UV-A on pig skin].

The effects of high and progressive doses of UVA are studied on skin, from a clinical and microscopic, both optic and electronic, point of view. We use pigskin as pattern, due to its similarity to human skin and a PUVA 200 Waldman as source of radiation.

Animals↗

[Mucopurulent cervicitis at a clinic for sexually transmitted diseases].

In a series of 1,011 women seen in the Diagnosis Center of Sexually Transmitted Diseases of the Faculty of Medicine of Seville, we study the prevalence of cervical infections caused by Neisseria gonorrhoeae and/or Chlamydia trachomatis and also mucopurulent cervicitis (CMP), these last diagnosed by the presence of more than 10 polymorphonuclear leukocytes x 1,000 magnification in Gram stain of secretion or endocervical mucopus. We calculate the predictive value that the diagnosis of the CMP had in detecting cervical infection by chlamydia and gonococcus. N. gonorrhoeae was isolated in 56 patients (5.5%), C. trachomatis in 83 (8.2%) and both in 15 (1.5%). In all, 154 women presented cervical infections, which correlates to a prevalence of 15.2%. CMP was diagnosed in 267 patients and, of these, 43.4% had cervical infection accused by N. gonorrhoeae and/or C. trachomatis. The diagnosis criteria of CMP used as predictors of cervical infection, had a sensibility of 0.75 and a specificity of 0.82, with a positive predictive value of 0.42.

Chlamydia Infections↗

[Diffuse cutaneous mastocytosis. Apropos of 2 familial cases].

The observation of two cases of diffuse cutaneous mastocytosis (DCM) with familiar characteristics in a man and his daughter, with only diffuse infiltration of the skin in the former and the girl also with blister and gastrointestinal participation, was the reason to do histological and ultrastructural studies. The authors observed a good therapeutic response to ketotifen and cyproheptadine, although the dose was higher than the usual one.

Adult↗

[A premature aging syndrome hard to classify].

In order to describe the observation of "premature aging", in a 20 year old woman, the clinical characteristics of other genodermatosis are reviewed, and the question of differential diagnosis and etiopathogenesis is raised concluding that these syndromes would have a continuous clinicopathological spectrum with various possibilities of manifestation.

Adult↗

[De Sanctis-Cacchione syndrome. Apropos of 2 cases].

We report two cases of xeroderma pigmentosum (XP), with neurologic alterations, representing a partial, although not complete form of the syndrome of De Sanctis-Cacchione. The clinical and aetiological features of the condition are discussed.

Adolescent↗

[Congenital lymphedema].

We add to the dermatologic bibliography, a family with two exceptional cases of congenital lymphedema. We comment etiopathogenesis, clinical, associations and complications, and insisting on the necessity of forward diagnostic.

Adult↗

[Clinical and epidemiological study of boutonneuse fever in Andalusia: apropos of 36 cases].

Boutonneuse fever is a rare disease, it accounts for 0.091% of all the patients who consult the Department of Medical-Surgical Dermatology in the Faculty of Medicine of Seville. It is clearly a disease of seasonal incidence, appearing most frequently during the summer, which affects both sexes equally at middle age, and is most frequent in rural areas, although it is increasing in urban districts. The term "Mediterranean fever" is correct, understanding that it is a disease afflicting Mediterranean countries, but has nothing to do with proximity to the sea.

Adolescent↗