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Biomedical subjects

F Cardinale

Publications and source records attributed to F Cardinale.

33 records · Page 2Linked to original sources
PubMed1996

[Temporal lobe epilepsy: stereotaxic methods].

We give a description of stereotaxic methodology as originally elaborated by the S.te Anne Hospital School in Paris, and successively modified and utilised in Niguarda Hospital in Milan. Performing a stereotactic arteriography and ventriculography should allow the appreciation of minimal modification of vascular anatomy, identification of sulci and gyri by utilising stereoscopic technique and the proportional grid, based on bicommissural line, evaluation of the morphological abnormalities and their precise reconstruction in the intracranial space. Anatomical information obtained by this kind of examinations are essential for intracerebral stereo-EEG investigation and for planning surgical procedure.

Brain Mapping↗
PubMed1996

[Short account of modern history of surgery in temporal lobe epilepsy].

We make an overview of the most significant historical steps of the temporal lobe epilepsies surgical treatment, from the first description, at the end of 19th century, to recent times. We also describe the history of neuropsichological testing (mainly Wada test), extra- and intra-cranial EEG-recordings, synchronised electro-clinical monitoring, structural and functional neuroimaging. We mainly tried to point out that the selection of candidates to surgical treatment should be based, despite any technological development, on a synoptical anatomo-electroclinical reasoning.

Diagnostic Imaging↗
PubMed1992

Aberrations in titre and avidity of serum IgM and IgG antibodies to microbial and food antigens in IgA deficiency.

The antibody levels and relative avidity of serum IgM and IgG antibodies against E. coli O antigens, poliovirus type 1 and beta-lactoglobulin were determined with enzyme-linked immunosorbent techniques in IgA deficient (IgAd) patients with frequent respiratory tract infections and healthy IgAd individuals. Healthy individuals with normal immunoglobulin levels served as controls. The IgM antibody levels against the bacterial, viral and food antigens and the IgG antibody levels against the bacterial antigens were significantly higher in the IgAd group with recurrent infections than in the group of healthy IgAd individuals. The symptomatic IgAd group had significantly higher levels of the IgG antibodies against the bacterial antigen, also when compared with controls. In contrast the healthy IgAd individuals had the highest avidities of IgM antibodies to the viral and food antigens. The high avidities of antibodies could be a compensatory host defence mechanism in IgAd. These aberrations may appear as a consequence of increased mucosal exposure in IgAd to antigens such as E. coli or beta-lactoglobulin, but presumably not to poliovirus which is only exceptionally present in the milieux. They could also be a result of the previously suggested dysregulation of antibody responses in IgAd.

Antibody Affinity↗
PubMed1983

Ependymomas of the spinal cord.

Many patients with spinal cord ependymomas (SCE) undoubtedly benefit from post-operative radiation therapy; however, because of the wide variability in the total doses given, the optimal post-operative dose for SCE remains unclear. Several recent papers recommend total doses of 4000 rad to 5000 rad in 4 1/2 to 6 weeks. Unfortunately, only a small number of patients reported in the literature have been consistently treated to these high dose recommendations. Nine consecutive adult patients with SCE have been treated in a consistent way at Yale-New Haven Hospital with total doses of approximately 4500 rad to 5000 rad at 180 rad to 200 rad per day. The acute and chronic morbidity from such treatment has been minimal and no patient has had a local recurrence at 8 months to 8 years following treatment.

Adolescent↗
PubMed1983

The effect of subtotal resection on the dose of radiation required to cure the rat rhabdomyosarcoma BA1112.

Dose response curves were established for local control of the rat rhabdomyosarcoma BA1112 for radiation alone and for radiation following a cytoreductive operation. Removal of one-half of the tumor prior to irradiation did not significantly alter the dose of radiation necessary to cure 50 per cent of the tumors. This experimental result confirms the theoretic predictions and suggests that, to be useful in combination with radiation, surgical treatment must remove in excess of 90 per cent of the tumor.

Animals↗
PubMed1979

Evaluation of a new vaginal contraceptive.

A new chemical contraceptive in the form of a vaginal suppository was evaluated in a series of in vitro and in vivo tests and compared to a leading contraceptive foam and cream. Good in vitro spermicidal effect was observed, but problems in solubility and the position of the suppository against the external cervical os may lead to less clinical effectiveness if not properly evaluated prior to its use.

Female↗
PubMed1977

Radiation therapy of carcinoma of the tonsil.

The results of treatment with radiation therapy of 65 cases of epidermoid carcinoma of the palatine tonsil have been reviewed. The major determinant of prognosis is the stage of the primary lesion. Failure usually results from the inability to control local grossly detectable tumor. Thirteen of thirteen T1 lesions but only two of sixteen T3 lesions were locally cured with external beam radiation therapy. No difference in survival was noted between patients with no clinical adenopathy vs those with clinically involved movable ipsilateral adenopathy.

Adult↗