[Larsen's syndrome: clinico-radiologic aspects in an 18-month-old infant].
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Biomedical subjects
Publications and source records attributed to F Carnevale.
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A family is described in which two sibs of a consanguineous marriage have alopecia, convulsions, EEG anomalies and mental retardation. Although the children have significant features resembling those described by Moynahan, this syndrome appears to be different in the mode of inheritance and in other aspects (sensorineural hearing loss in the male, syndactyly in the female).
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After description of etiopathogenetic, anatomopathological and clinical aspects of the disease, the authors relate about a case of ochronotic arthropathy, lining on its typical radiological patterns. Scintigraphic study with 99mTc-pertechnetate and with 99mTc-pyrophosphate, excluding any phlogistic component, agree with dysmetabolic and degenerative nature of this arthropathy.
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Sixty-seven workers employed in incapsulating and manufacturing antibiotics were studied by the authors by means of questionnaire, environmental survey, clinical examination and hematochemical, immunologic and microbiological determinations. The main features of respiratory and genital disturbances are discussed. Two cases of occupational asthma due to ampicillin were detected. Twenty-four out of forty-five female workers were found to be affected with vaginitis (due to Candida albicans in fourteen): a relationship with the working environment is hypothesized. The digestive tract disturbances are reported and the prevalence of dental discoloration is stressed. Finally the psycho-pathological pattern of the factory workers is outlined.
Two manufacturing processes are reported by the authors, which proved to be sources of lead poisoning hazard, due to the presently employed row materials. The results of a survey performed in 50 pewter manufacturing workers, as well as in 16 workmen involved in artistic bronze melting, are also reported. The inspection of the manufacturing processes made it possible to find out the poison sources in both the above mentioned types of industry.
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Economical, social and technical interrelations between synthetic dyes' production and bladder cancer in workmen engaged in the manufacture are reviewed. International situation is the background of Italian situation, mainly of the Lombardy region and Turin area. For decades social actors, individuals and institutions, acted as separate bodies, contributed to delay and omit the protection of workers' health. The situation changed when scientific knowledge, technical developments and workers' commitment prioritized workers' health as a main goal. The epidemic of bladder cancers among dyestuff workers was a cornerstone in the development of a different scenario in the production responsibility, workers' participation and eventually scientific community. The authors hypothesise that in our country these events stimulated the growth of epidemiology and epidemiologists; furthermore since then institutions promulgated a new and up-to-date wave of protective legislation in the workers' H&S field.
The European Union (EU) has recently twice amended the framework Council Directive 90/394/CEE on the protection of workers from risks related to exposure to carcinogens at work: protective measures were extended to category 1 and 2 mutagens; a new carcinogenic agent was identified in "work involving exposure to hardwood dusts" and three exposure limit values were fixed for carcinogens. The EU Member States are required to incorporate amending Directives into national legislation not later than 29 April 2003. Italy acknowledged these directives by the Decree 66/00 of the 25/2/2000. In this paper the development and the evolution of European legislation in the twenty years from 1980 to 2000 are overviewed: first, occupational exposure limits were defined and introduced for harmful chemicals, then for occupational carcinogens and later three binding limit values for benzene, VCM and hardwood dusts were fixed. The paper attempts to identify the expected problems and advantages that incorporation of the amending Directives will have on the protection of workers from carcinogenic risk.
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