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F Caroli

Publications and source records attributed to F Caroli.

At least 55 records · Page 3Linked to original sources
PubMed1982

[The sector and the 30 June 1838 law].

The two current foundations of the French organization of mental health, administratively speaking, are sectorisation and, on the legal side, the law of 30 june 1838. A historical study of the principles which led to the promulgation of these texts, shows that these two foundations are opposed, in fact, by the theories which support them. The law of 1838 stipulated the creation of asylums with a view not only to protecting society but also to protecting the patients from an environment which was incompatible with their recovery. History has proved that these asylums have in fact become places of exclusion. From this statement the necessity of diversification of the structure of psychiatric care and the development of organisations outside the hospital, has become apparent. The policy of sectorisation is to develop the whole of these means, preserving the insertion of the mentally sick patient into his usual social and family environment. With the contradiction which emerges from the existence of a law recognising only internment prefaced by a sanitary policy which extols the preeminence of care outside the hospital, a certain number of difficulties and distorsions between theory and practice can be expected.

Commitment of Persons with Psychiatric Disorders↗
PubMed1981

Spinal chordomas in infancy. Report of a case and analysis of the literature.

Chordomas are extremely rare among the spinal tumors in pediatric age. The sacrococcygeal region is the typical site of such a lesion. A case of spinal chordoma in a child 4 years old, at the T12-L1 level, is reported. The tumor was surgically removed and a local radiotherapy was performed, but 9 months later spreading of lung metastases was observed. The unusual site along the vertebral column and the metastatic potential of this tumor are discussed. The very few cases reported in the literature were analyzed.

Child, Preschool↗
PubMed1975

[Trial of interruption of antiparkinson drugs in long term treatments with neuroleptics].

The authors by placebo methods interrupted the antiparkinsonian treatment in chronic psychotic patients who had a neuroleptic treatment for at least three months. Three weeks after: 72 percent had to receive the antiparkinsonian they took before, in consequence of extrapyramidal manifestations (an half of the sample receive this antiparkinsonian during the first week), and more than a third presented an acute psychotic outbreak. However, 28 percent of the total sample were still with placebo. Authors are questioning the psychotropic activity of antiparkinsonians, the influence of neuroleptic doses and the specificity of each administred neuroleptic. They conclude in opposition with other authors, to the necessity of prescribing continuously antiparkinsonians in most of the cases of chronic psychoses, in long-term neuroleptic treatment.

Adult↗
PubMedDate not supplied

Exclusion of the SCN2B gene as candidate for CMT4B.

Charcot-Marie-Tooth disease type 4B (CMT4B) is a demyelinating autosomal recessive motor and sensory neuropathy characterised by focally folded myelin sheaths in the peripheral nerve. The CMT4B gene has been localised by homozygosity mapping and haplotype sharing in the 11q23 region. A cDNA encoding for the beta 2 subunit of the human brain sodium channel, SCN2B, has been recently assigned to the same chromosomal interval by FISH. The SCN2B gene has been considered a good candidate for CMT4B on the basis of protein homology, chromosomal localisation, and putative biological function of the coded product. In this paper, we report the genomic structure of the SCN2B gene consisting of 4 exons and 3 introns spanning a region of approximately 12 Kb. In addition, a search for mutations in patients affected with CMT4B as well as a refined physical localisation excludes SCN2B as the CMT4B gene.

Base Sequence↗
PubMedDate not supplied

An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity.

Sphingolipid activator proteins are small glycoproteins required for the degradation of sphingolipids by specific lysosomal hydrolases. Four of them, called saposins, are encoded by the prosaposin gene, the product of which is proteolytically cleaved into the four mature saposin proteins (saposins A, B, C, D). One of these, saposin B, is necessary in the hydrolysis of sulphatide by arylsulphatase A where it presents the solubilised substrate to the enzyme. As an alternative to arylsulphatase A deficiency, deficiency of saposin B causes metachromatic leukodystrophy. We identified a previously undescribed mutation (N215K) in the prosaposin gene of a patient with metachromatic leukodystrophy but with normal arylsulphatase A activity and elevated sulphatide in urine. The mutation involves a highly conserved amino acidic residue and abolishes the only N-glycosylation site of saposin B.

Amino Acid Sequence↗
PubMedDate not supplied

[Neuropsychiatric manifestations and quinolones. Apropos of a case].

The authors specified, briefly, the different subgroups and prevalence of the molecules from the quinolone family: Nalidixic acid (synthesised in 1958), the quinolones of second generation (oxilinic acid, piromidique, pipemidique and flumequine) and the quinolones of third generation (ciprofloxacine, norfloxacine, ofloxacine, perfloxacine). After having mentioned the extent and the importance of using these antibiotics in infections, they stressed the fact that the quinolones are antibiotics which are largely prescribed in clinics and hospitals. The authors reported afterwards the observation of a young female, without any precedent neuropsychiatric disorders having shown a complex clinical state with neurological and psychiatric disturbances during the first day of treatment for a urinary infection with 4 tablets of flumequine 400 mg per day (instead of 3 recommended). Mrs. A. 25 years of age was seen to during the night at The "Consultation Psychiatrique d'Orientation et d'Accueil" (C.P.O.A.). of Sainte-Anne hospital by the resident psychiatric of a General Hospital "after behavioural disturbances". In fact, about 3 hours before and 15 minutes after the third dose of flumequine (2 tablets of 400 mg), this makes the total dose taken over 12 hours is equal to 400 x 4 = 1,600 mg, the patient developed an intense discomfort with blurred vision accompanied by nausea, followed by a state of restlessness and incomprehensible speech. A testimony by relatives revealed that she suffered, shortly afterwards, a generalised fit which affected her 4 limbs with a fixation of her eyes and hypersalivation and convulsions without either swallowing the tongue or involuntary urination.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Laser therapy for the treatment of brain tumors.

The author examine the specific cases where laser therapy may be indicated for the treatment of brain tumors. The different types of lasers currently available are described and the effects on the tissue, at different powers and with different modalities of use, are reported. On the basis of experience reported in literature, the Author describes the characteristics and the fields of application of the 1.32 nm Nd:YAG laser, the superpulse CO2 and the Nd:YAG with sapphire tips for contact laser surgery. The advantages of laser surgery as opposed to the traditional techniques in the most frequently observed tumors, are also described.

Brain Neoplasms↗
PubMedDate not supplied

[2 rare neuro-ophthalmologic complications of long-term treatment with lithium salts].

We describe two patients with unusual neuro-ophthalmologic complications during long-term therapy with lithium carbonate given for bipolar affective disorder, "benign" intracranial hypertension in one, and downbeat nystagmus, with oscillopsia in the other. A review of the literature is proposed. Though rare, such neuro-ophthalmologic manifestations are worth being recognised since they usually disappear with cessation--when possible--of lithium therapy.

Adult↗
PubMedDate not supplied

[Psychiatric manifestations and HIV infection. Apropos of a case].

Psychiatric symptoms in AIDS have been noted in the literature. The case report of a young man with HIV showing psychotic features is presented. The course of the illness points to a possible schizophrenia incipiens. This raises two issues: the neurotropic potential of the virus and its involvement in the occurrence of these psychiatric troubles.

AIDS-Related Complex↗
PubMedDate not supplied

[Psychiatric emergency and somatic disorders].

The authors made a survey in the setting of the Ste Anne hospital Emergency outpatient clinic to determine the incidence of somatic troubles in mental patients during a crisis situation. 1,000 patients were examined during a 24 day period. More than half of somatic problems had not been addressed to priori to Psychiatric consultation. More over, during those psycho-organic troubles, no precise information had been made available in half of the patient population. In 3% of cases, hospitalization could not continue in a psychiatric setting, which points to both the difficulty in assessing the medical capacity of psychiatric institutions ("secteurs") and acceptance of mental patients by the general medical hospital.

Adult↗