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Biomedical subjects

F Carvajal

Publications and source records attributed to F Carvajal.

11 recordsLinked to original sources
PubMed2002

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome.

AIMS/HYPOTHESIS: Insulin resistance with increased risk of Type II (non-insulin-dependent) diabetes is a common feature of polycystic ovary syndrome (PCOS). To investigate antecedents of metabolic disorders in family members of patients with PCOS, we evaluated glucose tolerance and insulin resistance in parents of patients with PCOS compared to parents of healthy women. METHODS: A total of 200 parents of women with clinical and hormonal evidence of PCOS (PCOSp) and 120 parents of healthy normally cycling women (HWp) were studied. A 75-g OGGT was performed and subjects were classified according to the World Health Organization (WHO) criteria (1999). Serum glucose and insulin were measured before the glucose load and 30, 60 and 120 min after. C-peptide and sex hormone-binding globulin were also determined before the glucose load. Insulin resistance was assessed by HOMA model and ISI composite. RESULTS: The prevalence of Type II diabetes was 1.89-(1.06-3.38)-fold higher in PCOSp compared to HWp. Insulin resistance, evaluated by HOMA(IR)and ISI composite was also significantly higher in the PCOSp group compared to the HWp group. After both study groups were distributed by sex, and adjusted by age and BMI, the metabolic parameters were still significantly different between PCOSp and HWp. CONCLUSIONS/INTERPRETATION: The data suggest that parents of PCOS women exhibit insulin resistance and Type II diabetes more frequently than those of healthy women, thus constituting a high-risk group but an ideal cohort to detect and prevent the development of Type II diabetes.

Adolescent↗
PubMed2001

[Polycystic ovary syndrome: the importance of establishing diagnosis].

Polycystic ovary syndrome (PCOS) is a very common disorder that occurs up to 10% of premenopausal women. Although PCOS is known to be associated with a higher reproductive morbility and increased risk of hormone dependent-cancer, its diagnosis is particularly important because PCOS is strongly linked to insulin resistance. This involves a major risk of early metabolic and cardiovascular complications. On the other hand, the prevalence of metabolic disorders associated with insulin resistance is higher in family members of patients with PCOS than in those of normal women, which suggests that the treatment of this syndrome should be preventive rather than symptomatic. For that reason, PCOS might be considered a signal of a family disorder, a route to diabetes and a public health problem.

Female↗
PubMed2000

Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.

An evaluation of 3 different methods for malaria diagnosis was carried out in an urban area of low endemicity on the Pacific coast of Colombia. Samples were collected from 833 symptomatic patients at a malaria clinic and examined by the polymerase chain reaction (PCR), quantitative buffy coat (QBC; Becton Dickinson, Franklin Lakes, NJ) method, and the traditional thick blood smear. The prevalence of Plasmodium falciparum malaria was 5.88% by thick blood smear, 7.34% by the QBC method, and 21.87% by PCR. The agreement between microscopists was 99.5%. The agreement between the QBC method and thick blood smear was 96.13% (n = 745). Samples positive by PCR but negative by thick blood smear or conversely negative by PCR and positive by thick blood smear were usually of low-level parasitemias. All 3 methods showed agreement in 76.3% of the samples. Sixty-nine (18.8%) samples were positive by PCR but negative by the other 2 methods. Ten samples were positive by both the QBC method and thick blood smear but negative by PCR; most of them had low-level parasitemias. The use of malaria diagnostic methods for epidemiologic surveillance is discussed.

Animals↗
PubMed1999

Hypermasculinity and academic goal-setting: an exploratory study.

The relation between gender-role percepts and academic goal-setting was explored. An inventory examining the aspects of masculinity that would facilitate or inhibit academic goal-setting was developed based on a literature review of how masculinity relates to academic behaviors. A diverse sample of students (120 male, 147 female, 14 not indicating sex) was measured on three aspects of sex and academic goal-setting behavior. Factor analysis confirmed the content validity of masculine factors having facilitative (Mastery Competitiveness) and inhibitory (Antisocial Competitiveness) academic properties. Regression analyses indicated that sex-role orientations (Competitiveness and Hypermasculinity) significantly predicted academic goal-setting behaviors (R2 = .136). Finally, men scored higher than women on the subscales measuring Hypermasculinity and Antisocial or Competitiveness, while there were no sex differences on the Mastery Competitiveness subscale. The implications of these findings and suggestions for research are discussed.

Adolescent↗
PubMed1997

Mother and infant smiling exchanges during face-to-face interaction in infants with and without Down syndrome.

We examined social smiling in infants with and without Down syndrome, aged from 3.2 to 13.6 months old. They were videotaped during an episode of spontaneous face-to-face interaction and a subsequent mother's still-face situation. Results indicated that infants smiled longer in the spontaneous face-to-face episode than in the still-face episode, even though this result was only significant in typically developing infants. Typically developing infants also smiled for a longer period than Down's syndrome infants during the spontaneous interaction episode. Moreover, infant's smile preceded the onset of the mother's smile, but in 6.2- to 13.6-month-old typically developing infants, the probability of mothers smiling before infants increased. These findings emphasize the possible existence of differences in the development of facial expression from signs to social symbols between infants with and without Down syndrome.

Adult↗
PubMed1997

[Iodine nutrition in school children of four census areas of Chile].

BACKGROUND: Although endemic goiter is an easily controlled chronic disease, it continues to be a serious global public health problem. AIM: To study iodine nutrition in school age children from different areas of Chile. SUBJECTS AND METHODS: Thyroid gland was palpated in 4181 school age children from Calama, Santiago, Temuco and Punta Arenas. Urinary iodine excretion was measured to 9% of these children and iodine concentration in salt for human consumption obtained in each of these areas was determined. RESULTS: A 9% goiter prevalence in boys and 11% prevalence in girls was detected. The prevalence of goiter Ia was 6.5% and the figure in different geographic areas was similar. Iodine concentration in salt for human consumption was adequate according to Chilean legislation (82.6, 95.7, 96.8 and 93.2 micrograms ugI/g salt in Calama, Santiago, Temuco and Punta Arenas respectively). Urinary iodine excretion in boys and girls was 1695 and 1802 micrograms l/g creatinine in Calama, 680 and 732 in Santiago, 574 and 690 in Temuco, 570 and 528 in Punta Arenas. These values are well above recommendations. CONCLUSIONS: Endemic goiter is no longer a problem in Chile. The importance of a continuous surveillance of iodine nutrition in Chile and the reduction of salt iodine concentration required by Chilean legislation is underscored.

Censuses↗
PubMed1994

[Endemic goiter in three census areas of Chile].

The goal of the present study was to evaluate the current status of endemic goiter in Chile. 3500 students of basic education from public schools in three censor areas of the country were studied: 1000 in Calam (North), 1000 in Temuco (South) and 1500 in Santiago (Center). Socio-economic level was evaluated according to the Graffar scale. Two trained physicians determined body weight, height and size of the goiter through palpation of the thyroid gland (according to W.H.O. classification). Iodine in urine was determined in 20% of the students. Iodine insalt was determined in samples obtained in the three areas. A goiter prevalence of goiter of 11.4% in males and 12% in females was found, with a higher prevalence in females during puberty. A higher prevalence in the medium-low and low socio-economical levels was observed (12.4% and 14.4% respectively). The level of salt iodination was variable in the three areas (1/3 with concentration > than 100 parts per million (ppm), 1/3 between 60-100 ppm and 1/3 with < 60 ppm of iodine content). According to W.H.O. criteria, Chile has presently a low goiter prevalence, but the salt iodine concentration indicate the importance of a permanent surveillance of iodine nutrition.

Adolescent↗
PubMedDate not supplied

High density lipoprotein cholesterol in insulin-dependent diabetic children.

Thirty-one insulin-dependent diabetic children were studied (11 boys and 20 girls; 22 whites, 6 mulattoes and 3 Negroes; age-range: 8-14 years; mean age 11.7 years). According to the quality of their metabolic control the children were divided into 3 groups: Group 1, children in good metabolic control; Group 2, children in poor metabolic control but without ketosis; Group 3, children in severe ketoacidosis; 15 normal children (Group 4) served as controls. No hypercholesterolemia was found. As to blood sugar and serum triglyceride levels, significant differences were found between the control group and the diabetic groups as well as between the diabetic groups. When evaluating the result of HDL-cholesterol determinations we found a significant difference between the control group and Groups 2 and 3, as well as between diabetics in good control (Group 1) compared to Groups 2 and 3. We also found a correlation in diabetics in good control between blood sugar values and high HDL-cholesterol levels, and in diabetics in poor control between high blood sugar values and low HDL-cholesterol levels. No correlation was found between HDL-cholesterol and triglycerides in diabetes in poor metabolic control. In view of these findings the importance of reaching an optimal metabolic control in insulin-dependent children is emphasized, and the role of normoglycemia in the prevention of atherosclerosis is stressed.

Adolescent↗
PubMedDate not supplied

[Rehabilitation of the diabetic child in Cuba].

The author describes a series of important steps followed in Cuba for the rehabilitation of the diabetic child, like education of the patient and his relatives, active participation of the child in his treatment (self control), hospital attention advisable for a minimal period exclusively in severe cases, attention in office visits as ambulatory patient, participation in vocational, social and psychological orientation activities of the antidiabetic center, areas for sport and recreation, vocational camping for diabetic children, homes, education through press, television and radio of special programs on diabetes.

Child↗