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Biomedical subjects

F Cataliotti

Publications and source records attributed to F Cataliotti.

At least 19 recordsLinked to original sources

Needle perforation of the bowel in childhood.

Accidental ingestion of foreign bodies occurs frequently in childhood. The majority of them are passed spontaneously, and conservative management generally is recommended for foreign bodies in the stomach and duodenum. However, in some cases, operative intervention should be considered to prevent undesirable complications, such as intestinal perforation. Two cases of intestinal perforation owing to accidental ingestion of a needle are reported.

Abdomen, Acute↗

[Treatment of complications in hypospadias surgery: modern advancement].

BACKGROUND: With today's improved surgical techniques, complications in hypospadias surgery are seen less often, especially in distal form (1-5%). However, in proximal or complex hypospadias complications rate varied between 15 and 57%. Corrective surgery is mandatory in maior complications (urethrocutaneous fistulas, persistent chorde, urethral strictures, superficial skin separation). The search for the innovative surgical procedures and the optimal urethral substitute continues because each tissue has its particular shortcomings and disadvantages. METHODS: At our hospital complications occurred in 25 ( 15%) of 177 patients who underwent primary hypospadias repair between 1994 and 1998. 9 patients required further surgery to repair the complications of previous hypospadias operations performed at other institutions. When local epithelial tissue was not available, different surgical procedures were performed, using bladder or buccal mucosa graft and free or vascularized tunica vaginalis flaps. RESULTS: Follow up ranged from 3 to 6 years: the cosmetic and functional results were excellent. Small fistulas occurred in 3 patients and were corrected successfully in a subsequent surgical procedure using a tunica vaginalis wrap. CONCLUSIONS: The concept of using tunica vaginalis in urethral reconstruction represent a recent innovation. This tissue is a valid alternative in cases of multiple failed repairs.

Cutaneous Fistula↗

[Predicting factors of vesicoureteral evolution in children].

BACKGROUND: Despite the large number of children with reflux, management among urologists is still controversial. One of the most debated aspects is the choice between observation treatment or surgical treatment. METHODS: We assessed the natural course of children with vesico-ureteral reflux in the period 1990-1995, to correlate factors and identify patients with high risk of renal damage. We retrospectively reviewed the clinical course of 80 children with vesicoureteral reflux. Thirty-two were diagnosed during prenatal ultrasound scan. In the other cases urologic evaluation was requested because of urinary tract infections. The following data were analyzed: medical records, diagnostic and follow-up cystogram, renal imaging, medical therapy or surgical treatment carried out according to the reflux grade, diagnostic age, congenital reflux nephropathy or postnatal acquired scarring, voiding patterns, spontaneous resolution during medical management. Follow up ranged from 5 to 10 years. RESULTS: Vesicoureteral reflux resolved spontaneously in 29 patients: 25 were affected from moderate reflux, 4 from IV grade reflux. Surgical correction was carried out in 32 patients. Endoscopic treatment was performed in 25. Twenty-two children are still receiving prophylaxis and 12 were lost to follow-up. Congenital renal pathology correlate with poor outcome. CONCLUSIONS: The conclusion is drawn that there is a wide clinical variability in children with vescicoureteral reflux. The most important is host's susceptibility to urinary tract infection, but the severity of reflux, age of patients and congenital reflux nephropathy influence prognosis and long-term outcome.

Child↗

[Microproteinuria as a marker of renal damage in children].

BACKGROUND: Elevated urinary levels of microproteinuria or renal enzyme have shown to be associated with renal injury. Data collected in children with vesico-ureteral reflux (VUR) or hydronephrosis have been evaluated to identify a means of predicting renal damage. METHODS: Levels of urinary microproteinuria (N-acetyl-beta-glucosaminidase, aminoalanina peptidase, lisozyme, beta(2)-microglobulin) were evaluated with immunoassay in catheterized or voided urine. The levels of urinary creatinine were also determined. Of the 85 children enrolled in this study 22 were affected from reflux, 16 had hydronephrosis. Urine was obtained from the bladder in all children and also from renal pelvis in 9 patients at surgery for ureteropelvic junction obstruction. In addition, urine was obtained from 27 patients with a variety of pathophysiological conditions (neoplasia, ematuria, parenteral nutrition, ecc.). Normal healthy controls were performed in 20 children who volunteered for the study. RESULTS: In the group of children affected from reflux urinary microprotein elevated levels were in 18. In children with hydronephrosis pathological findings were observed in 2 cases. Abnormal pattern was found in 27 patients as response to various agents. Data obtained in healthy children were normal. Sensitivity in reflecting renal damage makes urinary enzymes measurement attractive as an indicator of renal dysfunction. CONCLUSIONS: Urinary microproteinuria evaluation may be a useful marker of progression of renal injury in children with reflux. However, excretion level of these microproteins is not helpful in identifying upper tract obstruction in small children, but values arise in those left untreated.

Biomarkers↗

Ovarian cysts in newborns.

Before the introduction of ultrasonography (US), ovarian cysts in newborns were thought to be rare. With the extended use of real-time US, prenatal detection has increased. There is still considerable controversy regarding the best treatment of these neonatal findings. A total of 27 instances in 24 consecutive newborns of antenatally-diagnosed ovarian cysts were reviewed for US data, management, and outcome to assess the ante- and postnatal evolution of the cyst and establish appropriate therapy. The cysts detected during pregnancy were studied by repeated postnatal US studies. In 10 children (2 with bilateral cysts) the cyst evolved spontaneously toward regression. Fourteen patients were operated upon; 10 had complex and 4 (in 1 bilateral) had simple cysts. Cystectomy was employed when possible to preserve the ovarian parenchyma (3 cases); in the remaining cases oophorectomy was performed. Histologically, the cysts were of follicular origin or necrosis made a diagnosis impossible. US was found to be a helpful diagnostic tool for simple ovarian cysts, but could not reliably distinguish between benign and malignant tumors if a sonographically complex lesion was present. Based on our experience, surgical management of ovarian cysts should be reserved to complex masses. Simple cysts can be monitored safely by close US follow-up; surgery is indicated if the cyst fails to regress after several months or becomes symptomatic.

Cesarean Section↗

Relationship between upper gastrointestinal bleeding and non steroidal anti-inflammatory drugs in children.

The authors evaluated the relationship between drug intake and upper gastrointestinal (GI) bleeding. The endoscopic files of the previous 2 years were reviewed and the incidence and age and sex distribution recorded. GI bleeding is indication for a high percentage of lower endoscopies and a low percentage of upper endoscopies. On the other hand, although rarer upper GI bleeding is more severe and frequently related to drug ingestion. About 50% of cases showed gastric erosions secondary to drug intake. A relation between gastric bleeding and paracetamol is considered, as is the possibility of preventing secondary severe bleeding by pharmacologic gastric protection in children with risk factors such as chronic use of other drugs or portal hypertension.

Acetaminophen↗

Ultrasonography and gastric emptying: evaluation in infants with gastroesophageal reflux.

We have applied ultrasonography to the evaluation of gastric emptying in children. Two different populations have been investigated: normal children and children with gastroesophageal reflux. All the patients were less than 6 months of age. The diagnosis of gastroesophageal reflux was defined by 24-h pH measurement. The technique, used to measure gastric emptying, is the one described by Bolondi et al. In this research we used the simplified method. All children had been submitted to the examination after 4-h fasting. The standard meal was the usual milk formula, 300 ml/m2 body surface area (BSA). A cross-section area of the gastric antrum was determined before a meal and every 15 min for 2 h. The examination was concluded after two measurements were equal to the basal one. The normal gastric emptying curve was determined by a control group. Patients with gastroesophageal reflux showed three different kind of gastric emptying: (a) normal gastric emptying in 20% of cases, (b) abnormal gastric emptying in 15% of cases, and (c) intermediate cases in which the plateau curve is abnormal but the end time of gastric emptying is normal. We defined these three kinds of curves as type I or normal, type III or abnormal, and type II or intermediate. The estimate of frequency in patients with gastroesophageal reflux is similar to the reported data of the literature.

Gastric Emptying↗