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Biomedical subjects

F Chevaux

Publications and source records attributed to F Chevaux.

7 recordsLinked to original sources
PubMed1984

[Effect of the PSMF diet on plasma lipids and lipoproteins in obese subjects].

The influence of weight reduction on plasma lipids, lipoproteins and apoproteins was studied in 14 patients (8 females and 6 males) with varying degrees of obesity. After 4 weeks on hypocaloric diet (PSMF), an 8% weight loss was associated with a significant decrease in total cholesterol (18%), triglycerides (47%) and phospholipids (20%). No significant change was observed in HDL-cholesterol. The HDL-cholesterol/total cholesterol ratio was increased. The greatest decrease was observed in VLDL fractions. The decreases in apoprotein A and B were 19% and 15% respectively. These findings indicate that favourable changes in plasma lipoproteins are achieved after weight loss on hypocaloric diet.

Adult↗
PubMed1982

Insulin resistance and carbohydrate oxidation in patients with chemical diabetes.

In six patients with chemical diabetes, insulin resistance was assessed by the steady-state plasma glucose (SSPG) level during a constant infusion of epinephrine, propranolol, glucose and insulin. During the infusion, the patients had elevated SSPG levels (174 +/- 20 mg/100 ml), compared with six control subjects (96 +/- 3 mg/100 ml, p less than 0.005), demonstrating increased insulin resistance. However, during the infusion, the rate of carbohydrate oxidation was similar in both groups. These results suggest that when insulinemia is controlled, the plasma glucose concentration in chemical diabetics during glucose infusion reaches hyperglycemic levels allowing normalisation of carbohydrate oxidation. Hyperglycemia can thus be considered to be a regulatory mechanism favouring glucose uptake and oxidation in patients with chemical diabetes.

Adult↗
PubMed1982

Influence of plasma glucose and insulin concentrations on carbohydrate oxidation in man.

The influence of both plasma glucose and insulin levels on the rate of carbohydrate oxidation was separately assessed in control subjects. During inhibition of endogenous insulin secretion by epinephrine + propranolol, glucose infusion produced an increase in carbohydrate oxidation when plasma glucose levels reached approximately 200 mg/100 ml. Addition of exogenous insulin to the glucose infusion was accompanied by a further rise in carbohydrate oxidation and a decrease in plasma glucose level. It was concluded that hyperglycemia without insulin response represents a compensatory mechanism which favours peripheral glucose utilization.

Adult↗
PubMed1981

[Alcoholic hepatitis: histo-clinical evaluation].

The clinical and histological symptoms of alcoholic hepatitis diagnosed from liver biopsies are investigated and the results compared with the extent of the histological lesions classified as small, medium or large. Nonspecific symptoms were variable and were not found to be related to the histological damage. The only recurring symptom was hepatomegaly, which was present in 95% of the patients studied. Histo-clinical comparison showed the clinical symptoms to be very variable, and it is concluded that accurate diagnosis and knowledge of the severity of the lesion can only be obtained from liver biopsy samples.

Female↗
PubMed1980

[Alcoholic hepatitis].

Alcoholic hepatitis is defined by histological findings, i.e. Mallory bodies, necrosis and polynuclear infiltration. It may be accompanied by steatosis and more or less advanced fibrosis. The clinical picture is variable, ranging from a total absence of symptoms to high fever, jaundice and encephalopathy. Laboratory findings reveal high polynuclear white cell counts, SGOT (but not SGPT) and glutamate dehydrogenase levels. The prognosis varies according to the series studied. The pathogenesis is unclear but cellular and humoral immunity mechanisms may play a role. Therapeutic possibilities are limited, corticosteroids only being useful in very serious cases. Alcoholic hepatitis is not a nosological entity but an acute inflammatory reaction of the liver due to cell necrosis caused by alcohol, and can therefore occur at any stage of alcoholic liver.

Adult↗