Biomedical subjects

F Chiarelli

Publications and source records attributed to F Chiarelli.

238 records · Page 14Linked to original sources

PubMedDate not supplied

[Pharmacological prevention of exercise-induced bronchospasm: review of the literature and trial of disodium cromoglycate, fenoterol and ipratropium bromide in a pediatric population].

Exercise-induced bronchospasm (EIB) is an instrumentally-measurable paraphysiologic phenomenon, related to bronchial hyperreactivity in asthmatic children. Therefore EIB is very useful to evaluate airways hyperreactivity and pharmacological treatment in asthmatic child. We have evaluate EIB inhibition and bronchodilator effect of three drugs: Disodiumcromoglycate (DSCG), Fenoterol (F), Ipratropium Bromide (IB), in a group of 27 asymptomatic and therapy-free asthmatic children. The bronchial provocation test was performed by physical exercise (free-running for six minutes) according to criteria stated by Paediatric Bronchopneumology Group of S.I.P. Therefore we have analysed the most recent studies to correlate our results with other's data: our study confirm DSCG and Beta-adrenergic drugs effectiveness; theophylline has a similar validity, but is less useful in clinical practice; anticholinergic drugs and corticosteroids seem less valid; the new drugs (Ketotifen, alpha-blockers and calcium antagonists) need further controlled studies.

Adolescent↗

PubMedDate not supplied

[Bronchiolitis: new pathogenetic aspects and personal cases].

The etiological, epidemiological and pathogenetical features of bronchiolitis and some clinical and biochemical data concerning seventy nine cases were discussed. It has been underlined the possible pathogenetical role of immunoallergic mechanism (immunoreactions type II, III, IV and VI), and of alterations of humoral immunocompetence (rise of IgM and deficit of IgA). Moreover it has been pointed out that hereditary, socioeconomical and environmental factors could play an important role in determining the seriousness of the clinical picture. The relationship between bronchiolitis and the respiratory diseases of the following years have been examinated.

Bronchiolitis, Viral↗

PubMedDate not supplied

Education, knowledge and metabolic control in children with type 1 diabetes.

We studied thirty diabetic patients and we evaluated their knowledge of main topics of diabetes mellitus. The level of the knowledge was evaluated by multiple choice questionnaires. On the basis of score obtained the patients were divided into two groups: Group A, with high knowledge level, Group B, with low knowledge level. All the patients were followed-up for a 12 months period after a careful education. At the end of follow-up, we compared the Group A patients with another group of 14 diabetic children, who have followed an educational programme from the diagnosis of the disease (Group C). We assessed the knowledge score and the principal metabolic parameters in the three groups of patients; during the follow-up, we found a significant increase of these parameters in Group A and B patients, more evident in Group A patients. At the end of follow-up, the Group C patients showed a higher knowledge score and metabolic parameters than the Group A children. This study shows that education of disease is important for the increase of metabolic parameters and its usefulness is higher if is carried out from the onset of the disease.

Adolescent↗

PubMedDate not supplied

[Family history and risk of insulin-dependent diabetes mellitus: a population-based case-control study].

Insulin-dependent diabetes mellitus (IDDM) is a worldwide occurrence disease of childhood with genetic, environmental and familial risk factors. Our study aims to evaluate family history as a determinant of IDDM. In a population-based case-control study informations on all incident IDDM cases, age 0-14, diagnosed between January 1st 1990 and December 31st 1996 were taken from the IDDM population-based register of the Abruzzo Region. The control group was taken from the lists of children attending family paediatricians. The family history data collection for IDDM and non insulin-dependent diabetes (NIDDM) were obtained by a questionnaire, administered to parents. Risk of IDDM associated with familiarity in first and second degree relatives was estimated using conditional regression analysis. Our results show that the risk of developing IDDM is increased by positive family history (OR = 3.99; 95% c.i. 1.56-10.23). The risk of IDDM for children whose fathers or brothers are affected by IDDM is respectively 11 and 20 times higher than for children with no family history. Family history for NIDDM does not influence the risk.

Adolescent↗