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Biomedical subjects

F Christ

Publications and source records attributed to F Christ.

At least 37 records · Page 2Linked to original sources
PubMed1992

[A comparison of the value of magnetic resonance tomography and computed tomography in Nelson syndrome patients].

The hypophyses of 13 patients with Nelson syndrome following bilateral adrenalectomy were examined by MRI and CT. Diffuse enlargement of the hypophysis was demonstrated in 8 patients by CT and in 9 by MRI. Compared with CT, MRI provides better demonstration of tumour development, such as abnormal convexity of the cranial margin of the hypophysis (MRI 4/13, CT 1/13), displacement of the infundibulum (MRI 4/13, CT 0/13) or optic chiasm (MRI 2/13, CT 0/13). MRI also provides diagnostically important differentiation between scar tissue and recurrence of tumour following hypophysectomy (MRI 1/3, CT 0/3) and more accurate demonstration of infiltration of the cavernous sinus (MRI 4/13, CT 2/13). CT is superior only in showing the floor of the sella. MRI is the method of choice for imaging in cases of Nelson syndrome.

Adrenalectomy↗
PubMed1992

Mercury in silastic strain gauge plethysmography for the clinical assessment of the microcirculation.

We have used the mercury in silastic strain gauge plethysmography (MSG) system, which is wholly non-invasive, to obtain values (mean +/- s.e.m.) for the following parameters in the legs of supine control subjects: venous pressure (Pv) 9.89 +/- 0.88 mmHg, vascular compliance (Comp) 3.50 +/- 0.29 ml 100 g-1 mmHg-1 x 10(-2), microvascular hydraulic conductivity (Kf) 4.10 +/- 0.16 ml min-1 100 g-1 mmHg-1 x 10(-3) and isovolumetric venous pressure (Pvi) 22.12 +/- 0.82 mmHg. On passive foot-down tilting of control subjects through about 45 degrees, both Pv and Pvi rose to 28.00 +/- 2.33 and 36.58 +/- 2.29 mmHg respectively. The increases in both parameters were highly significant, P < 0.0001. We found that the time course of the vascular compliance component was short if small pressure steps were used. The value increased markedly if large steps were used. We also observed that none of the microvascular parameters studied in the arms differed from those in the legs of the same subjects. We observed that the mean value Kf in the arms of 12 young, non-neuropathic diabetics (9.08 +/- 6.12 x 10(-3)) was significantly greater than that of age and sex-matched controls (P < 0.001). Studies on 14 venous ulceration patients indicated that the values for Kf and Pv were unchanged, whilst those of vascular compliance (5.60 +/- 0.58 x 10(-2) ml 100 g-1 mmHg-1) and Pvi (37.30 +/- 2.25 mmHg) were significantly greater than those found in age-matched controls (P < 0.002 and 0.001, respectively). We feel that Pvi is a useful index of microvascular perfusion. We attribute the pressure-dependent difference, in the time course of the vascular compliance response, to the veni-arteriolar reflex. We feel that the pressure dependency of this response might form the basis for the assessment of peripheral autonomic neuropathy. We believe that the MSG system offers a means of monitoring the development of pathologies resulting from microvascular under-perfusion and, of course, the improvement in response to therapeutic interventions.

Adult↗
PubMed1991

[Spontaneous regression of liver metastases in neuroendocrine tumors of the abdomen].

In six patients with hepatically metastasised gastrointestinal tumours of neuro-endocrinal origin, including one each islet cell carcinoma and gastrinoma of the pancreas, one cloacogenic carcinoma (a rare type of anal cancer), and three carcinoid tumours of the small bowel, spontaneous liquefaction inside echogenic liver metastases was demonstrated by ultrasound. The hepatic lesions were classified as being of "bull's-eye-" shape without "badge" pattern. Chemotherapy had no effect on their ultrasonographic imaging. With regard to our observations, liquefying processes were far more common in these well-differentiated tumour metastases than in poorly differentiated fast-proliferating malignancies (about 1:40). Assessment of liquefaction, however, has obviously no influence on the prognosis of progress speed. Ultrasonographic differential diagnosis includes focal inflammatory disease of the liver, if there is no evidence of a primary tumour.

Carcinoid Tumor↗
PubMed1991

[The radiological image of pleural lipomas with special reference to computed tomography].

Diagnostic assessment of focal pleural mass requires CT examination, particularly in follow-up of anamnestic tumour conditions. Since 1976 well-delineated pleural masses that were suspicious for malignancy on chest films, were identified in 11 patients as lipomas, using CT. They showed semicircular, oval or polygonal shape, but no really "spheric" aspect on biplane chest films. Main diameters of these masses were 2.5 to 6 cm and only once 11 cm. Density values mostly ranged from -110 to -70 HE (min. -133, max. -22 HE) in nonenhanced CT studies. Findings were localised adjacent to the parietal pleura seven times (in one patient two separate findings) and to the diaphragmatic pleura five times. In 7751 CT examinations of the chest, the incidence of pleural lipomas was 0.14%, their prevalence concerning solid pleural lesions being 5.3%. Among all intrathoracic lipomas those in mediastinal and paracardial location respectively were definitely more often (30 patients).

Aged↗
PubMed1991

The assessment of the microcirculatory effects of dobutamine using mercury in silastic strain gauge plethysmography in man.

Adverse changes in the microcirculation are currently considered as the most likely common pathway of organ failure, dramatically manifest in the multiple organ failure syndrome. We have investigated 28 patients presenting with gross cardiovascular instability due to septic shock or haemorrhage, using standard invasive methods of monitoring (Physiological Profile). We combined this study with a computer assisted mercury-in-rubber strain gauge plethysmography (MSG) measurement, for a parallel (non-invasive) assessment of peripheral microcirculatory function. We started the investigation on patient arrival in ICU and continued it during their resuscitation regime, which essentially consisted of fluid loading together with inotropic support, where necessary. We found highly significant changes in isovolumetric venous pressure (Pvi), determined by the MSG technique, when we compared survivors (27.29 +/- 1.65 mmHg, mean +/- s.e.m.) with non-survivors (39.5 +/- 2.97 mmHg, P less than 0.001). To investigate the role of dobutamine in patient improvement we compared the Pvi values obtained from the MSG studies and demonstrated a significant decrease from the initial value (38.2 +/- 2.4 mmHg) to the final one (25.4 +/- 2.4 mmHg), obtained after weaning the patients off dobutamine. Marked cyclic changes in limb circumference (vasomotion) were also observed and their appearance correlated well with accepted parameters of cardiovascular instability. We propose that changes in both Pvi and Vm are useful indices of microvascular hypoperfusion which is probably the underlying cause of pathology in both patient groups.

Dobutamine↗
PubMed1990

[A pseudosarcoma of the duodenum].

Pseudosarcoma is a rare malignant neoplasm composed of both carcinomatous and sarcomatous elements. It occurs most frequently in the uterus. When located in the gastrointestinal tract the lethality is almost 100% one year after the diagnosis. Clinical observations and radiological findings in a 52-year old patient with pseudosarcoma of the duodenum are presented in this report.

Carcinosarcoma↗
PubMed1990

[Juvenile occlusion syndrome of the inferior vena cava with left renal deficiency].

In three juvenile patients, one female and two males aged 14 to 21 years, there were recent deep vein thromboses of the lower limbs due to previous infrahepatic occlusion of the inferior vena cava associated with a shrunken left kidney without clinical manifestation of a nephrotic syndrome. Possible reasons and impacts of this probably congenital peculiar vascular syndrome are discussed. Radiodiagnostic management in juvenile patients with recurrent venous thromboses of the lower part of the body is explained with special respect to secondary phenomena of other retroperitoneal organs like adrenals, inner pelvis and testicles.

Adolescent↗
PubMed1989

[Exertional dyspnea, chest pain, dizziness].

A 66 year old patient with chest pain and exertional dyspnea is described. Auscultation and physical examination showed signs of aortic stenosis combined with aortic insufficiency. Electrocardiography revealed left ventricular hypertrophy with associated ST-segment and T-wave abnormalities. Color blood flow imaging confirmed severe combined aortic stenosis and regurgitation, the hemodynamic evaluation demonstrated the indication for aortic valve replacement.

Aged↗
PubMed1989

[Recurrent thrombophlebitis, weakness].

The 46-year-old woman was admitted with an acute inflammatory swelling of the left forearm. During the previous six months the patient had suffered from recurrent thromboses of the superficial veins associated with generalized physical weakness. The gynaecological history was remarkable for hypermenorrhea and metrorrhagia. On examination, the signs of an acute thrombophlebitis with concomitant lymphangitis were observed. In the lower right abdomen there was a palpable tumor. Laboratory findings showed a mild anemia and indices of inflammation. Subsequent procedures (abdominal sonography, gynaecological examination) further substantiated the suspicion of an underlying malignant process. Hysterectomy and histological examination revealed two different carcinomas of the right ovary and of the uterine cave. Already during the uncomplicated postoperative period the thrombophlebitis completely regressed.

Adenocarcinoma↗
PubMed1989

[The heart ventricle wall in digital subtraction angiocardiography].

Digital subtraction angiography, using a time interval difference mode in relation to a suitable mask, provides a means of showing the myocardium in every phase of the cardiac cycle. The endo- and peri-cardial contours and the thickness of the myocardium in both ventricles can be demonstrated accurately. Artifacts are usually due to displacements of the heart or to tachycardia.

Angiocardiography↗
PubMed1988

[Nuclear medicine diagnosis and therapy of distant metastases of pheochromocytoma].

Three foci, suspected of being metastases, were discovered by sonography and computed tomography in a patient twelve years after resection of a phaeochromocytoma and six years after resection of liver metastases. The findings were confirmed by scintigraphy with 131I-metaiodobenzylguanidine (MIBG) and treated with 3700 MBq of MIBG, to be repeated in the near future.

3-Iodobenzylguanidine↗
PubMed1988

[Functionally significant changes in the shape of the right ventricle in digital subtraction angiocardiography].

Experiences in i.v. digital subtraction angiocardiography (DSAC) including so-called parametric imaging for morphological delineation of the right ventricle are illustrated. 32 patients with different anatomical and haemodynamic disturbances of the right ventricle were subjected to these examinations. Special emphasis is placed on pulmonary stenosis, particularly on its infundibular manifestations. For visualisation of muscular or fibrous bulging or other changes of the outflow tract of the right ventricle, analysis of the amplitudes is very suitable to produce cumulative pictures of ventricular wall motion during a cardiac cycle. Obstructive wall alterations within the infundibular part become visible even if they occur only during certain phases of the myocardial action, usually in late systole than otherwise.

Adolescent↗
PubMed1988

Magnetic resonance (MR) imaging of prostatic tumours, a comparison with X-ray CT and transrectal sonography (TRS).

A total of 7 healthy volunteers and 31 patients have been examined clinically, by MRI, TRS, and biopsy. In those patients with established carcinoma, a CT examination was also performed. For the MRI study, a superconducting MR 2000 imager (Picker International) operated at 0.15 T was used with multiplanar SE and IR sequences. SE sequences with long echo times detected prostatitis, adenoma and carcinoma of the prostate with a high degree of sensitivity. However, at present, differentiation between adenoma, prostatitis and carcinoma is not possible with sufficient accuracy. In these studies we were unable to establish a correlation between the signal pattern and staging and/or grading of the carcinoma. Reliable diagnosis of a prostate carcinoma still requires a biopsy. Because of the high soft tissue contrast and the possibility of selecting any orientation for the plane under investigation, however, MRI represents an improvement in the preoperative diagnosis of local spread.

Aged↗