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Biomedical subjects

F Clara

Publications and source records attributed to F Clara.

6 recordsLinked to original sources
PubMed1988

[Systemic thrombolysis using streptokinase. Experiences at the Civic Hospital of Lugano in the framework of the ISIS-2 study].

With a small group of Swiss hospitals we had an opportunity of participating in ISIS-2, the major study on thrombolysis in acute myocardial infarction. Experience with our microcosm (Ospedale Civico Lugano) was compared with the macrocosm of the results of ISIS-2 in 17,187 randomized patients (in brackets). Mortality was 5.1% (7.8%) in our streptokinase group and 15.8% (12.8%) in our placebo group. In the ISIS-2 study the combination of thrombolytic therapy with streptokinase, and of antiplatelet therapy with aspirin, showed a reduction of approximately one third in acute mortality of myocardial infarction, stroke and reinfarction. Our experience confirms the reduced incidence of allergic side effects (3.5%), major bleeding (0.3%) and minor bleeding (2.9%) during or after thrombolytic therapy.

Administration, Oral↗
PubMed1984

[Clinical picture and diagnosis of pulmonary embolism].

Despite technological progress, the clinical diagnosis of acute pulmonary embolism (APE) is often problematic, There are no typical or specific clinical cardiopulmonary symptoms or signs that serve for the diagnosis, and only the absence of tachypnea seems to be an important exclusion criterion. Electrocardiogram, laboratory tests (including circulatory markers of thromboembolic disease) and blood gas analysis are also unspecific. Chest X-ray provides a high incidence of suggestive abnormalities and remains the most helpful routine procedure. While the negative perfusion lung scan is the best procedure for exclusion of APE, the positive scan suffers from too low specificity to be of real interest. In contrast, pulmonary angiography is the diagnostic method of choice. Besides detection of pulmonary emboli and of the extent of perfusion abnormalities, pulmonary angiography allows measurement of useful parameters of cardiac and pulmonary function, precise monitoring of evolution and administration of selective thrombolytic therapy. The diagnostic value of recent noninvasive diagnostic procedures in APE (echocardiography, Doppler echocardiography, computer tomography, plethysmography) is briefly discussed.

Blood Gas Analysis↗
PubMed1977

[Clinical experiences with the serum digitalis concentration. 1006 radioimmunological determinations].

Serum digitalis concentration was measured radioimmunologically on 1006 patients in the period from 1974-1976. The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established. Clinical signs of toxicity appear at a serum level of digoxin above 2.5 ng/ml. Therapeutic limits (range) are most influenced by individual factors. Serum digoxin determination is especially necessary in patients with renal failure and in undisciplined patients with erratic digitalis intake. It is a useful aid in controlling the course of digitalis intoxication, in "low dosage" digitalization and in the case of possible drug interactions.

Arrhythmias, Cardiac↗