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Biomedical subjects

F Clemente Yago

Publications and source records attributed to F Clemente Yago.

8 recordsLinked to original sources

[Childhood kala-azar: the cases of a decade].

The aim of our work was to review the epidemiological, clinical and laboratory features of the cases of Kala-azar in our hospital during a decade in order to outline data that might be useful in helping to make an earlier diagnosis and subsequently, earlier treatment. We report eighteen cases of visceral Leishmaniasis treated in our hospital between January 1981 and December 1990. The ages of the patients varied between five months and seven years. In our experience, medullar aspirate was the most effective diagnostic method. However, it this test is negative, specific serological tests should be included in the assessment of any pediatric inpatient with fever and splenomegaly. In our opinion, it is very important to keep this disease in mind, especially in non-endemic areas.

Age Factors↗

[Lactose-free formula versus adapted formula in acute infantile diarrhea].

We have studied a population of 60 children with acute diarrhea. In order to evaluate the benefit of lactose suppression from the diet on the clinical course of the disease, these children were randomly assigned to either the control group or the experimental group. No differences were found in respects to the duration of the illness (lactose containing formula 4.8 +/- 2 days vs lactose free formula 4.4 +/- 3.1 days). Similarly, body weight change did not change significantly (12.5 +/- 235.8 gr vs 55.9 +/- 238.0 gr, t-test non-significant). Children fed with the lactose free diet voided less frequently than did children in the control group (12.8 +/- 10.5 vs 19.8 +/- 9.5 times; p < 0.01). This difference disappeared when only invasive diarrheas were considered (26.6 +/- 12 vs 21.5 +/- 9.5 voidings; t-test nonsignificant). Finally, only 2 of the 32 cases fed with lactose containing formula showed clinical intolerance to lactose. Therefore, we conclude that in patients with mild-to-moderate acute diarrhea, the resumption of feeding should be undertaken with the same formula that they were previously fed, restricting the use of lactose free formulas to selected cases and to those children in whom a standard milk made symptoms reappear.

Acute Disease↗

[Neonatal septicemia: incidence and risk factors].

The cases of 131 newborns with positive blood cultures have been reviewed. These children were born in our hospital between 1985 and 1990. We found that the incidence of sepsis was 4.3/1000 newborns. Early neonatal sepsis was the most frequent, representing 58% of the cases. Late sepsis in hospitalized infants represented 1.34% of the cases. Streptococcus B was the microorganism most frequently isolated (26.7%), followed by S. epidermidis (19.8%), E. coli (13.7%) and S. aureus (10.68%). In over 50% of the cases of early sepsis, maternal-fetal risk factors were present. Mortality was 7.6%, with half of these cases due to Streptococcus B.

Cross Infection↗

[Fatal nanism: 3 different entities].

Three cases of congenital dwarfism are presented. All of them are lethal and represent the three better known nonviable nosologic entities: Achondrogenesis I, Achondrogesis II and Thanatophoric dwarfism. According to clinical features and radiologic data it is possible to approach the diagnosis accurately. We comment genetic, clinic, radiologic and histologic aspects of these processes. It is important to establish a differential diagnosis as these entities have different genetic basis, what influences genetic counsel.

Achondroplasia↗

[Mineral metabolism of calcium, magnesium and phosphorus in the normal newborn infant].

The mineral metabolism of calcium, magnesium and phosphorus in 20 newborns and infants was studied. All children were born from term deliveries and none presented clinic, biochemistry signs or radiological evidences of bone mineral metabolism disturbances. In this way, metabolic blance technics were applied. Net absorption of calcium, magnesium and phosphorus were: 54,9 +/- 18,8; 8,7 +/- 4,8 and 64,6 +/- 14,2 mg/kg/day respectively. The retentions of the three elements were: 54,4 +/- 20,6; 7,4 +/- 4,5 and 43,2 +/- 13,6 mg/kg/day. A significative lineal correlation between plasmatic levels of 250Hd and 24,25 (OH)2D with calcium retention was found. The correlation of intestinal calcium apsorption was positive and significative only with 250HD levels. It wasn't found signification between the vitamin D metabolites with the magnesium and phosphorus balance. In other way, it was found a relation between the dietary intake of this two elements with absorption and retention of both of them.

Calcium↗

[Reference levels for phenylalanine and tyrosine in discs impregnated with blood during analysis by HPLC].

Aromatic amino acids tyrosine and phenylalanine have been measured on paper with dried blood samples, using high performance liquid chromatography (HPLC) in reverse phase. The aim of this procedure is to discriminate unclear cases of general screening for aminoacidopathies avoiding unnecessary retest. Plasma normal values of tyrosine and phenylalanine have been obtained in full term babies (0.82 +/- 0.39 mg/dl and 0.53 +/- 0.23 mg/dl) preschool boy (0.78 +/- 0.21 mg/dl and 0.63 +/- 0.20 mg/dl), school boys (0.89 +/- 0.16 and 0.76 +/- 0.22 mg/dl) and normal adults (1.48 +/- 0.19 and 1.41 +/- 0.12 mg/dl). In order to assess if fasting levels can be altered by breast feeding or formula feeding, a sample was obtained after various feeds and postprandially. Results show no differences before or after feeding. A group of malnourished infants showed greater plasma values of tyrosine and phenylalanine (p less than 0.002) conversely a group children suffering for diabetes showed no differences when comparing with matched age controls. In conclusion, measurement of tyrosine and phenylalanine on dried blood in filter paper is accurate enough, to avoid unnecessary recall in unclear cases of screening, and those levels do not alter significantly with normal milk intake.

Adolescent↗

[Mail handling: a possible cause of error in the non-selective screening for congenital hypothyroidism].

Remittance by mail of blood samples and subsequent time of permanency in mail boxes are not supposed to be best thermic conditions for dried blood samples in paper used for neonatal screening. With the idea of checking if temperatures variations can altered or not the content of TSH and T4, some samples of known concentrations of TSH and T4 has been heated to different temperatures between less than -40 degrees C and 100 degrees C during weekly periods. At such temperatures between less than -40 degrees C and 25 degrees C significant hormones losses are not observed. Nevertheless under higher temperatures the percentages of losses increases. Specifically between 37 degrees C and 60 degrees C an hormonal loss of approximately 36% is observed. T4 had also suffered losses of concentration in relation with temperature. These variations make indispensable the change of the way of managing samples that could had suffered modifications with temperatures, and that have been sent by mail. Therefore, considering that about a 40% loss can exist, limit of 40 mu UI/ml should be modified about 25 mu UI/ml.

Blood Specimen Collection↗