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F Colasson

Publications and source records attributed to F Colasson.

5 recordsLinked to original sources

[The teratogenic risks of anti-epileptic treatment].

Janz and Fuchs, in 1964, started the question of the teratogenicity of anti-epileptic drugs by their publications. In Poitiers we have carried out a retrospective study on 56 epileptic women who gave birth to 85 children. We found that 12 of these children (14.4%) had malformations. These results confirm that there is a risk of malformation in the use of anti-epileptic measures, a conclusion which corresponds with those of the majority of authors. The hydantoins and the barbiturates seem to have an equal role to play but they do so by different mechanisms. The most common malformations are hare-lips or cleft palates and cardiopathies. The most obvious ones are the facial deformities and skeletal abnormalities; none of these are lethal. In spite of this risk all authors state that it is important to carry on with anti-epileptic treatment for the mothers' sake.

Abnormalities, Drug-Induced↗

[Antispasmodic agents (author's transl)].

The authors summarize current knowledge of the anatomical and physiological basis of uterine contractions and their inhibition, and review the different antispasmodics used at the present time in France. For each product they describe the pharmacological effects, the mode of administration, maternal and fetal tolerance, indications, contra-indications and efficacy. The choice of product and their association are then discussed. The authors emphasize the value of treatment by these products, and stress the need for careful prescribing, because of the severity of the accidents provoked by overdosage or when their contra-indications are not respected.

Adrenergic beta-Agonists↗

[Tetanus and pregnancy. Labor with assisted respiration].

The authors report a rare case in which tetanus occurred with a pregnancy near term. In this particular case of pregnancy with risk for the fetus and mother associated with one another, curative treatment with monitoring of the state of the fetus and assisted respiration for the mother resulted in the birth of a live child who could be brought up normally and a cure for the mother without having to resort to caesarean section.

Adult↗