PubMed Health⌕ Search

Biomedical subjects

F Colla

Publications and source records attributed to F Colla.

28 records · Page 2Linked to original sources
PubMed1989

Adenylate cyclase and cyclic AMP-phosphodiesterase activities of fetal membranes: effect of insulin.

Basal activity and response to insulin of adenylate cyclase and cyclic AMP-phosphodiesterase were measured in the fetal membranes before and after labor. Basal activity of adenylate cyclase showed only slight variations after delivery when compared to that observed before labor. Enzyme activity was significantly although weakly decreased by insulin both in the amnion and in chorion before labor, while after delivery a weaker non-significant inhibition was observed. Basal activity of cyclic AMP-phosphodiesterase was lower after delivery with respect to that observed before labor. Insulin inhibited enzyme activity in all conditions. Cyclic AMP levels in intact tissue were not substantially modified by insulin.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMedDate not supplied

Thyroiditis due to Brucella melitensis--report of two cases.

Two cases of thyroiditis due to Brucella melitensis are reported. Both occurred in foreigners working in Switzerland and presented with characteristic symptoms of thyroiditis which masked those of brucellosis. Cultures were diagnostic. One patient had concomitant thyroid malignancy. Both showed normal thyroid function and were cured following antibiotic treatment.

Adult↗
PubMedDate not supplied

Mycobacterium kansasii and Pneumocystis carinii pneumonia in a patient with the acquired immunodeficiency syndrome.

The case of a Swiss AIDS patient suffering from Mycobacterium kansasii lung disease is described. The course of the illness was complicated by Pneumocystis carinii pneumonia. Therapy with isoniazid, ethambutol, clofazimine, ciprofloxacin and, after the onset of P. carinii pneumonia, trimethoprim-sulfamethoxazole led to a rapid and sustained clinical recovery of the patient.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Pathologic features of endometrial carcinoma in elderly women.

It has been estimated that more than two-thirds of cancers occur in people over 65 years of age: endometrial cancer (EC) is the most common gynaecologic cancer in the U.S. and represents the fourth most common malignancy in women. Some authors have reported that EC in elderly women was more aggressive, histologically less-differentiated and often non-endometrioid when compared with EC in the younger population. The purpose of this retrospective study is to evaluate the pathologic features of EC in women 70 years old or over compared with those of younger patients. Between 1987 and 1997, 174 patients with EC were surgically treated: 52 women were 70 years old or over. Two-thirds of both groups had surgical Stage I tumors: 54% of surgical Stage I tumors in the elderly had myometrial invasion more than 50% compared with 32% in the younger group (p<0.01). On the whole 37% of elderly patients had Stage IC tumors compared with 21% in younger women (p<0.01). Seventy-five percent of elderly women had Grade 2 or 3 tumors compared with 55% of younger patients (p<0.005). The majority of EC was endometrioid in both groups: 8% of elderly patients had clear-cell carcinomas compared with 4% of younger women (p not significant). No elderly patients showed nodal metastasis (0 out of 10): 9% of younger women had pelvic or para-aortic metastasis. The median follow-up was 78 months. The overall survival in the elderly and in the younger group was 80% and 93%, respectively (p<0.01): in elderly women overall survival significantly varied according to histotype and depth of myometrial invasion in Stage I tumors. In conclusion patients 70 years old or over have a high probability of surgical Stage I EC but a significantly higher probability of deep myometrial invasion and less-differentiated tumors than younger women: the prognosis w as good but poorer than for younger patients.

Adult↗
PubMedDate not supplied

Glycosylated hemoglobin (HbA1) assay as a test for detection and surveillance of gestational diabetes. A reappraisal.

Total glycosylated hemoglobin (HbA1) levels were measured in 96 gestational diabetics and 139 normal pregnant women in order to assess their usefulness in detection and monitoring of gestational diabetes. Different, although not significant, behaviour of HbA1 values was found in gestational diabetics and controls throughout pregnancy. Significantly higher (p less than 0.005) HbA1 values were found in gestational diabetics between the 24th and the 32nd week of gestation. In spite of this finding a low sensitivity in detecting gestational diabetes was confirmed. HbA1 values and OGTT parameters did not correlate. Delivery of a large-for-date (LGA) baby was not associated with higher HbA1 levels. Overlapping HbA1 levels were found in gestational diabetics and normal pregnant women. This study confirm the low predictive value of HbA1 assay in gestational diabetes.

Adult↗
PubMedDate not supplied

[Osteopoikilosis--skin and joint manifestations].

Osteopoikilosis (Osteopathia condensans disseminata) is a rare and usually asymptomatic sclerosing bone dysplasia of unknown origin. Familial clustering suggests a dominant inheritance. The observation of a 47-year-old woman lead to differential diagnostic considerations in view of the literature on about 350 cases. For 2 years the patient has been complaining about pain and stiffness of both hands with swelling of the fingers. Additionally, she remarked about bilateral paresthesias corresponding to the sensory innervation of the median nerve. Clinical examination revealed a sensory carpal tunnel syndrome and mild synovitis of the proximal interphalangeal joints with skin induration and limited flexion of the fingers. In addition, some finger and toe nails showed pitting and most fingers had scar-like linear skin alterations. Radiologic findings showed symmetric, well-defined, homogeneous sclerosing areas in spongy bone. The combination of symmetrical sclerosing bone densities, hereditary character, and associated skin and joint manifestations suggests the existence of a general connective tissue disease.

Bone and Bones↗