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Biomedical subjects

F Collier

Publications and source records attributed to F Collier.

35 records · Page 2Linked to original sources
PubMed1985

Effect of retinoids on the growth, ultrastructure, and cytoskeletal structures of malignant rat osteoblasts.

A clonal rat osteogenic sarcoma cell line, UMR 106-06, was used to study the effects of retinoic acid (RA) on its growth and morphology. Retinoic acid caused a reversible, time and dose-dependent inhibition of growth. RA-treated cells were larger, were more adherent to the substratum, and contained fewer mitotic figures. Half-maximal growth inhibition was observed at 10(-8) M. Among the naturally occurring retinoids, RA was clearly the most potent while the arotinoids, Ro 13-7410 and Ro 13-6298, were approximately 50 times more potent than was RA. A similar range of potencies was observed in the cloning efficiencies of the cells in soft agar. Fluorescence microscopy revealed that RA treatment increased the cellular content and organization of F-actin fibers. Ultrastructural changes include decreased chromatin dispersion and increased number of nucleoli per nucleus, decreased rough endoplasmic reticulum, decreased electron density and number of mitochondria, and increased formation of microfilaments and microtubules. These results identify this clonal cell line, which has been extensively characterized as the malignant counterpart of the normal osteoblast, as a target for vitamin A action.

Actins↗
PubMedDate not supplied

Air medical transport of patients from offshore oil and gas facilities. Historical accident data and initial experience.

The offshore petroleum exploration and production industry (OSI) is isolated from traditional means of access to emergent health care and may benefit from the unique attributes of helicopter air medical transport. This study was undertaken to review the incidence of OSI-related incidents, injuries and deaths, and report the initial experience of a civilian hospital-based helicopter air transport program in the evacuation of offshore patients. It was learned that the mean annual incidence of major OSI accidents from 1980 to 1986 was 19.1 (+/- 7.0). Mean annual mortality and reported injury were 14.7 (+/- 7.6) and 36.7 (+/- 25.4) patients respectively. Fires and explosions were the most frequently reported events at 62 per year (+/- 11.5/year). Nine OSI patients were evacuated by helicopter during the study's eight-month pilot period (seven for trauma and two for medical illness). One of the nine patients had been exposed to a potentially hazardous substance, requiring changes in the air medical team's operations, aircraft and equipment. The study shows that the offshore petroleum environment is ideally suited for air medical transport, as injuries are common and medical illnesses are to be expected. However, air medical programs operating offshore must deal with additional regulatory requirements and develop operational procedures to ensure safety during these flights.

Accidents, Occupational↗
PubMedDate not supplied

Sensitivity of cortical transit and furosemide response in the diagnosis of renal obstruction. An experimental model.

Several radionuclide parameters are routinely used for the diagnosis of renal obstruction. In order to evaluate the sensitivity of those parameters, an experimental model of partial ureteral obstruction in rats was used. Neither the cortical transit time, nor the response to furosemide could serve to discriminate between obstructive and nonobstructive kidneys. These parameters were, however, more or less related to the degree of impairment of the single kidney glomerular filtration rate and should probably be considered as functional parameters reflecting the grade of the obstructive phenomenon.

Animals↗
PubMedDate not supplied

Child benefit.

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Adaptation, Psychological↗
PubMedDate not supplied

[Surgical treatment of deep burns in children (author's transl)].

The clinical material is described and the principles of burn wound treatment are indicated: --excision and grafting of third degree burns: early whenever possible, delayed if the diagnosis or the limits are difficult to appreciate;--local treatment with Silver-Sulfadiazine of second degree burns, and those of undetermined depth. The difficulty of diagnosing the exact depth of the burn as well as the problem of the sequelae are stressed. The treatment of the complications is mentioned, particularly of the large hypertrophic scars. More than ever, prevention seems to be essential, but also possible.

Burns↗
PubMedDate not supplied

[Evaluation of medical and surgical treatment of intussusception in children apropos of a review of 100 consecutive cases].

Evaluation of medical and surgical treatment of intussusception in children (a revue of 100 consecutive cases). The authors analysed 100 consecutive cases of intussusception hospitalized in the Department of Paediatric Surgery of the Brugmann University Hospital in Brussels. 90 baryum enemas were performed, 43 of which were curative, 57 children were operated upon. Their age varied from 3 months to 10 years, but 77% of the children were less than 2 years old. The authors paid particular attention to the observations of children who had surgical treatment. This study points out the importance of early diagnosis and treatment. After a delay of 24 hours, 81% patients needed surgery compared to 41% of those who presented earlier.

Barium Sulfate↗
PubMedDate not supplied

[Bochdalek's congenital diaphragmatic hernia: a clinical review of 114 cases].

During a retrospective multicentric study of the encountered congenital pathology of the diaphragmatic domes, we focused our special attention on the prevalence of the congenital Bochdalek hernia. 140 charts were statistically analysed. The seriousness of the medical and surgical emergency situation enticed the authors to examine the most important prognostic clinical features. The interval between diagnosis and surgical therapy should be as short as possible. Respiratory acidosis and resuscitation were a common denomination in all infants who succumbed in the post-operative period. The early occurrence (less than 6 hrs) of respiratory distress disclosed the seriousness of the associated pulmonary hypoplasia. Surgical technical problems were rare. This in contrast to the struggle against pulmonary arterial and capillary hypertension. Pulmonary vasodilator drugs have not convinced those who initiated their use.

Diaphragm↗
PubMedDate not supplied

[Anti-infections prophylaxis of infantile burns (author's transl)].

Analysis of 300 consecutive hospitalized children with burns. To prevent infection, patients are given a bath with chlorhexidine (0.03%) every day and their burns covered by silver sulfadiazine (1%) and occlusive dressings. In 5.3% of the children positive swabs were obtained during hospitalization and in only 2.3% on several occasions. No case of septicemia could be documented.

Biguanides↗