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Biomedical subjects

F Congy

Publications and source records attributed to F Congy.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Retrospective study of 290 cases of hyperthyroidism after 55 years of age without previously documented thyroid disorders].

Previous studies having shown differences in the clinical presentation of hyperthyroidism in the young and in the over sixty-years old patients, we studied the presentation of hyperthyroidism of late onset without previous thyroid disorder to determine if it continued to change with age after 55 years. Two hundred and ninety cases of hyperthyroidism presenting after the age of 55 years without a previous history of goitre, collected in the Department of Nuclear Medicine of the Pitié Hospital between January 1976 and May 1980, were analysed retrospectively. There was no significant correlation between age and heart rate or total circulating thyroxine (T4) and triiodothyronine (T3) concentration. A positive correlation with weight loss and a negative correlation with I 131 fixation were observed. It was higher in cases of atrial fibrillation and hyperthyroidism with normal thyroid scintigraphy. Graves' disease with goitre was associated with the most overt signs of thyrotoxicosis and the highest hormonal concentrations, contrarily to toxic adenoma. The T3 but not T4 concentration correlated positively with heart rate. T3 and T4 were positively correlated with weight loss, and this correlation remained significant at constant T4 and T3 concentrations.

Age Factors↗
PubMed1982

[Recent data on the epidemiology and etiology of Crohn's disease].

The disease described by Crohn and co-workers fifty years ago escapes precise definition as it involves not only the ileum but the whole digestive tract. When restricted to the colon, it cannot easily be differentiated from that other inflammatory disease of the large bowel: ulcerative colitis. Meanwhile, Crohn's disease seems to be increasingly frequent, spreading from north to south, with a higher incidence among Jews and relatives of patients presenting with the condition. This would suggest interaction between a specific genetic factor and an as yet undetermined environmental agent which becomes pathogenic in the digestive tract. The lesions of Crohn's disease point to an immune conflict but so far, no definite disorder of the immunoregulation system has been demonstrated.

Crohn Disease↗
PubMed1982

[The immunology of Crohn Disease (author's transl)].

Although the incidence of Crohn disease seems to be increasing, it's etiology remains unknown. The search for immunological mechanisms has been extensively carried out with conflicting results. At the present, most studies provide evidence suggesting a possible immunological dysfunction. Another interesting point is the possible role of an oxygen dependant cytotoxic activity of phagocytes in inflammatory processes, and particularly in Crohn disease.

Antibody Formation↗
PubMed1982

[Is a rise in haematocrit associated with a risk of cerebrovascular accident? A retrospective study of 150 subjects with previous CVA and 150 paired controls (author's transl)].

A retrospective study of the various factors associated with the risk of cerebrovascular accident (CVA) was conducted in 150 patients (87 women and 63 men) who had had a CVA and 150 paired control subjects of the same sex and age. No difference was found between these groups in systolic and diastolic BP, nor in blood glucose and cholesterol levels. However, there was a highly significant increase in haematocrit in CVA patients as compared with controls. The mean figures were +5,69% in men (p less than 0.00005) and + 3.85% in women (p less than 0.00001). It must be noted that the haematocrit values in CVA patients, although increased, remained within the normal range. A rise in blood viscosity could be the mechanism through which the haematocrit contributes to the risk of CVA.

Aged↗
PubMed1982

[Hodgkin's disease and idiopathic cardiomyopathy (author's transl)].

The authors report the case of a 36 years old man who has been successfully treated, ten years ago, with radiation therapy for stage II Hodgkin's disease, with sub-diaphragmatic involvement. The clinical course was unhappily marked by the development of progressive congestive heart failure which was related to an "idiopathic cardiomyopathy" anatomically confirmed. A literature review does not permit to find such another case. It was not possible to conclude if this association was fortuitous or not. But if could be compared to the increased risk of post-transplant lymphomas in patients with idiopathic cardiomyopathy.

Adult↗
PubMed1980

Influenzal acute myositis in the elderly.

We report an 84-year-old man with completely regressive acute myositis. The presumed etiology was an Influenza A virus infection, based on the serologic results.

Acute Disease↗
PubMed1979

[A case of distal mesenteric arteritis (author's transl)].

A case is reported of distal mesenteric arteritis discovered during operation and confirmed by arteriography. The arteritis was probably not inflammatory in origin, but could have been due to atheroma. Only one other case of this type has been reported.

Arteritis↗
PubMedDate not supplied

Respective roles of immune and nutritional factors in the priming of the immune response in the elderly.

Ninety-six institutionalized elderly (greater than 70 years old) (mean age: 82 +/- 7 years) subjects, negative for tetanus toxoid antibodies were primed with tetanus toxoid vaccination and dinitrochlorobenzene (DNCB). Correlations were studied between some immunological parameters, nutritional parameters prior to immunization and the immune response intensity after it. Levels of tetanus toxoid specific IgG (ELISA assay) were positively correlated with monocyte phagocytosis, DNCB response and prealbumin levels, and negatively correlated with total IgG, monocyte immune degradation and tetanus toxoid lymphocyte stimulation. No correlation was observed with IgA, IgM, PHA stimulation. Tetanus toxoid lymphocyte stimulation correlated positively with response to DNCB, and negatively with tetanus toxoid IgG as well as total IgG. DNCB response correlated with prealbumin, tetanus toxoid IgG and tetanus toxoid lymphocyte stimulation. Therefore, it appears that malnutrition, as measured by prealbumin level, is one of the main factors contributing to the inconstant senile immunodeficiency. Monocyte antigenic degradation function unaltered with age can impair immune response while conserved or increased phagocytosis enhances immune response in the elderly. High total IgG levels were linked with low specific responses to priming antigens. High specific antibody levels also correlated negatively with cellular specific response. It is assumed that regulatory IgG antibody accumulation, likely anti-idiotypic antibodies, play an important role in senile immunological depletion.

Aged↗