Biomedical subjects
Publications and source records attributed to F Coppi.
The best knowledge of the biological and genetic mechanism involved in the process of metastasizing must determine the attempt of elaborating new therapeutical modalities. The authors show the sequential events of the metastasizing process based on the most recent theories, underlining the way the organotropism of the neoplastic cells can be the explanation of the otherwise inexplicable metastases.
The authors briefly illustrate some biological and epidemiologic characteristics of the malignant urologic tumors; then they describe the modalities of metastasizing underlining that this process is determined not only by hematic and lymphatic dissemination but also by sequential and complex events "metastatic fall", involving multiple guest-tumor intersections to the organotropism of the neoplastic cells and to their intrinsic aggressiveness and to the histological type of tumor. Afterwards the authors analytically analyze the most important malignant neoplasms of the urogenital apparatus either as clinical importance or as statistic incidence.
The Author describes the etiopathogenetic and histological aspects of leukoplakia in comparison with the squamous metaplasia of vaginal type (trigonal leukoplakia). They present a description both under anatomic and clinic point of view to achieve a correct diagnostic and therapeutical assessment to give a standardization of the term "leukoplakia" which is often referred for different pathologies.