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Biomedical subjects

F Cormier

Publications and source records attributed to F Cormier.

60 records · Page 4Linked to original sources
PubMed1984

[Development of early erythroid precursors (BFUe) from mouse bone marrow in a serum-free culture media. Effect of hemin].

In culture medium containing albumin, iron saturated transferrin, phospholipids, cholesterol and erythropoietin, BFUe growth requires foetal Calf serum. Without serum the BFUe development is advantageously restored by the addition of hemin associated with spleen conditioned medium. In erythropoietin supplemented serum-free medium the growth of primitive erythroid precursor cells is closely dependent on growth factor supply found in spleen conditioned medium. Using this medium allows us to clearly distinguish between the respective effects of erythropoietin and of BPA on erythroid progenitor cells.

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PubMedDate not supplied

A canine iliac artery occlusion model.

This report describes an occlusive canine iliac artery model for use in experimental angioplasty procedures. Lesions were induced by overdistending and breaking the internal elastic lamina of the artery and implanting a 2-cm long occlusive collagen plug. The collagen plug diameter was varied to fit the iliac artery and caused immediate bilateral iliac occlusions. Histology of the lesions at 9 and 14 days (n = 2) showed that the lumen was filled with a mixture of fresh thrombus and collagen pad material (more collagen than thrombus) with focal disruptions of the internal elastic lamina. At 36 days (n = 2) the lumen was obliterated with a mixture of organizing thrombus and collagen pad material (more organizing thrombus than collagen). At 60 (n = 4) and 80 (n = 8) days the collagen pad had been completely replaced with organizing thrombus consisting of collagen fibers and hemosiderin-laden macrophages with persistent focal disruptions of the internal elastic lamina. These initial data demonstrate the ability to create fibrotic arterial occlusions in as short a time as 60 days and to provide a practical model to study methods for treating localized peripheral vascular occlusive disease.

Animals↗
PubMedDate not supplied

Laser-fused biologic vascular graft anastomoses.

Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model. Five animals had 4-cm length, 3-mm internal diameter grafts (n; eq 10) placed bilaterally as side-to-side A-V interpositions from the femoral artery to femoral vein. One A-V graft was placed using argon laser energy with the vessel edges aligned by 6-0 polypropylene traction sutures at 3 to 4 mm intervals. The contralateral graft was sutured using running 6-0 polypropylene suture. Anastomoses were successfully fashioned in all animals except for episodes of delayed bleeding at two laser-fused segments (15 min and 2 hrs) and one segment in a suture control (6 days). The implants were removed to evaluate the integrity and healing of the anastomoses at 2 hrs, 8 days, and at 7, 9, and 11 weeks. In all instances, there was no evidence of anastomotic dehissance or enlargement. Histologic examination of the anastomoses revealed coapted vessel and prosthetic edges in laser-fused specimens and a limited foreign-body response to the permanent sutures in the suture controls. In the longer term specimens there was marked intimal proliferation at the venous anastomosis in all implants, with recent bilateral occlusions of the 7 and 11 week implants at the venous connection. We conclude that laser fusion of biologic vascular prostheses to autogenous vessel is possible with healing and no evidence of anastomotic dehissance.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

[Isolated dissecting aneurysm of the superior mesenteric artery. Dysplasia, a rare cause of mesenteric ischemia. Report of a case].

We report a case of successful surgical revascularization of the superior mesenteric artery in a patient presenting with intestinal ischaemia due to fibrodysplasia. This is a rare pathology, with 5 cases operated in our institution and only 16 cases reported in the literature. Angiography may show other sites of arterial dysplasia. In such cases, success depends on early surgical revascularization.

Aortic Dissection↗
PubMedDate not supplied

[Aorto-arteriography of the lower limbs using carbon dioxide].

OBJECTIVES: Carbon dioxide is often used as a contrast medium for angiocardiography and has recently been proposed for peripheral arteriography. We therefore evaluated this method of opacification in comparison with iodine medium. METHODS: From December 1992 to February 1993, arteriographies using carbon dioxide contrast medium were performed in 13 patients (age range 57-83) with severe arteriopathies requiring revascularization: 2 aorta plus renal arteries, 2 aorta plus iliac and lower limb arteries, 9 lower limb arteries only. The intraarterial injections of carbon dioxide were delivered rapidly (< 20 sec) at a rate of 30 cm3/s (50 cm3/injection) for the aorta and 10-15 cm3/s (15-60 cm3/injection) for peripheral arteries. In 8 of the patients, control arteriographies were performed with iopamidol. RESULTS: The injections of carbon dioxide were well tolerated being painless in 12/13 patients. Digital subtraction images were satisfactory in 6, mediocre but conclusive in 5 and poor in 2. Images of distal arteries were the most difficult to interpret and images of the aorta were generally good. The low viscosity of carbon dioxide allowed the use of small 4F catheters. CONCLUSIONS: Carbon dioxide can be routinely used as a contrast medium, notably in diabetic patients, patients with renal impairment and those who are allergic to iodine based compounds.

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