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Biomedical subjects

F Cukier-Hemeury

Publications and source records attributed to F Cukier-Hemeury.

7 recordsLinked to original sources

[Wanting a child].

To want a child and to want to have a child are notions receiving renewed interest ever since the generalization of contraception and even more recently, the new methods of procreation. These two notions are compared and tested against biological data across historical, psychoanalytic and sociological works. A brief resume of research done with mothers of newborns underlines the ambiguity and the complex and dynamic character of the question. The desire for a child and the desire to have a child are different notions and one should discriminate between them.

Female↗

[Long-term fate of very-low-birth-weight children].

75 neonates with birth weights less than or equal to 1,250 g were admitted to a neonatal intensive care unit. 34 were followed up for about 4 years. 44% (15) of the surviving children are normal; 35% (12) present with minor sequellae compatible with normal familial, social and school life; 14.7% (5) presents with moderate sequellae; 6% (2) present with major sequellae. None presents with hydrocephalus, bedridden encephalopathy, deafness or blindness. Among these 34 children, 12 have growth retardation. All children with sequellae presented with important neurologic involvement during the neonatal period. No silent period was observed during follow-up. An early screening for the disorders is possible. The neonatal risks, often unappreciated or underestimated are, in most cases, foreseeable when taking into account the mother's history and course of pregnancy. Thanks to improvement of in utero screening techniques, proper cooperation between obstetricians and pediatricians should allow for selecting a better management for all very low birth weight prematures.

Brain Damage, Chronic↗

[Very low birth weight neonates. Results of management. Future prospects].

70 neonates with birth weights (BW) less than 1 250 g were treated at the intensive care unit for neonates (USINN), hôpital Port-Royal, from April 1st 1976 to July 31st 1977. 16 of them had intra-uterine growth retardation. In 20, BW cas under 1 000 g. Assisted ventilation was necessary in 54 (77%). 43 children (61%) survived, those who were born in the same hospital did so more often (88%) than those who came from other hospitals (53%) (p less than 0.01). These results show the needs and risks of the management of very low birth weight neonates: preventing hypothermia, assisted ventilation of long duration and risk of persisting ductus arteriosus, prolonged parenteral nutrition, risk of intracranial hemorrhage more especially as respiratory distress is more severe. In survivors, the high rate of respiratory sequellae (around 30%) suggests that the duration and intensity of assisted ventilation should be reduced as much as possible.

Follow-Up Studies↗

[Convulsions in neonates. Clinical, electrographic, etiopathogenic and prognostic aspects].

121 cases of neonatal convulsions, including 79 cases of status epilepticus and 42 cases of isolated convulsions are studied. The great number of premature infants (40/121 newborns born before a gestational age of 37 weeks) must be pointed out. The clinical symptoms and EEG activity occurring during the first 24 hours following the onset of convulsions are analysed. Their descriptions confirm previous ones. Comparison of the populations of preterm and term infants demonstrates that the pre- and post-ictal neurological states are equally severe in both groups and that there is no difference between groups in the more or less precocious onset of convulsions. The value of the interictal EEG already described in status epilepticus of terms infants as predicting a poor prognosis, is confirmed. In addition, the very poor prognosis of an abnormal EEG pattern of the premature newborn, i.e. an EEG lacking any pattern corresponding to any gestational age, is demonstrated. Such EEGs of very poor prognosis have been detected in 46 cases. They reveal the degree of severity of the cerebral lesions, EEG abnormalities and cerebral lesions varying with gestational age. This study confirms the relatively mild severity of isolated convulsions as compared to status epilepticus. It demonstrates the severity of convulsions in premature newborns and of the electrographical discharges without simultaneous clinical event. The prognostic value of the absence or presence of a sleep cycle as early as the 24 hours following the onset of convulsions must be noted. Most of the neonatal convulsions are secondary to birth hypoxia or asphyxia and to meningo-encephalitis. In this study the small number of seizures due to metabolic factors is striking and contrasts with their great frequency in other series. The cause of the seizures is unknown in 12% of the cases; some of these cases of unknown origin correspond to the description of the 'convulsions of the 5th day'. The prognosis in full-term newborns has been improved greatly in recent years, probably due to improvement in obstetrical and neonatal intensive care.

Brain↗

[Seizures in premature neonates and in full-term neonates (author's transl)].

Normal EEG rhythms depend on conceptional age (CA), i.e., gestational age plus legal age. To assess whether pathological rhythms are also related to the level of maturation. EEG seizures have been compared in 26 premature neonates (PN) - 16 from 26 to 32 weeks of CA, 10 from 33 to 36 weeks of CA - and in 20 full-term neonates (FTN). The amplitude, the frequency, the polarity, the duration of paroxysmal discharges, the presence of variations in localization and the presence of clinical seizures are not related to CA. In FTN, the discharges during seizures, display a more complex pattern; the foci of spike discharges are more often on the rolandic area; spikes or delta waves are more often asynchronous than in PN. In PN less than 32 weeks of CA, seizures occur more often in females than in males. The prognosis of seizures is more severe in PN than in FTN. The prognosis is also more severe in FTN with brief discharges (less than 3 min) than in those with long-lasting discharges. The seizures are mainly related to extensive intraventricular haemorrhage in PN, to cortical lesions in FTN.

Brain↗

[What does neonatal intensive care mean to the parents? (author's transl)].

Since 1975, the importance of the relationship between the parents and the doctors who care for neonates has been studied. The parents were interviewed from the time for admission and the interview analysed. The data show that allowing parents into the Unit, their participation in the care of the infants and above all their discussion with the doctors and nursing staff improved their relationship with the baby and the understanding of the illness.

Adult↗