PubMed Health⌕ Search

Biomedical subjects

F Cusimano

Publications and source records attributed to F Cusimano.

12 recordsLinked to original sources

Brainstem auditory evoked potentials in patients with mitochondrial encephalomyopathy.

Brainstem auditory evoked potentials (BAEPs) were evaluated in three patients with mitochondrial encephalomyopathy belonging to the same family. This study showed marked alterations of BAEPs in all patients: reduction of wave amplitude, poor repeatability of responses in test-retest and abnormalities in wave form and latency. The neuroradiological examinations (CT-scan, MRI) did not show significant structural brain abnormalities. Abnormal BAEPs in our patients may be related to central metabolic disorder rather than hearing loss.

Adult↗

The Jervell and Lange-Nielsen syndrome.

Deafness and electrocardiographic changes (prolongation of the Q-T interval and inversion of the T wave) with a clinical picture of syncopal attacks and sudden death, were described as a distinct syndrome by Jervell and Lange-Nielsen in 1957. The syndrome is inherited as an autosomal recessive trait. In this study, all the cases reported since 1957 and their proposed prevalence are reviewed. The authors describe the 4 cases they have studied, all of which presented congenital sensorineural hearing loss and electrocardiographic changes characteristic of the syndrome. The relatively high number of cases they have encountered casts doubt on literature that states that the syndrome occurs more frequently in Northern-European populations. Consequently, it is advisable to perform an electrocardiogram in all children affected by congenital deafness.

Audiometry↗

Sensorineural hearing loss in chronic otitis media.

A statistical study was done on the sensorineural component in hearing loss, using 595 patients suffering from Chronic Otitis Media (COM); of these, 195 with monolateral COM were taken into consideration. They presented criteria of valuation which excluded other possible causes of sensorineural hearing loss, such as exposure to acoustic trauma, ototoxic drugs, cardiovascular disease, past head injury and hereditary causes. The contralateral (healthy) ear served as a control. We determined the average sensorineural component in the hearing losses in relation to the age of onset and duration of the disease, examining it in relation to other eventual aural complications such as cholesteatoma. On the basis of the data obtained, we believe that the sensorineural component in hearing loss does not change with respect to the age of onset of COM, but the duration of COM does exert a significant influence.

Adult↗

Frequency discrimination for pure-tone and modulated stimuli: an evaluation of automatic and computerized test versions.

Monaural differential frequency discrimination (delta f/f) was investigated in the 32 ears of 16 normal-hearing young adults, using an automated test of pitch-memory (the AFTD of Grisanti, Boll. Ital. Audiol. Foniatr., 1978, 1, 166-169) wherein S, in analogy with Bekesy audiometry, continuously adjusts the frequency of alternating pure-tone bursts between discriminable-nondiscriminable, and using a computer-driven test of discrimination of frequency modulation (the CTFD of Biondi, E. et al, Comm. LXV Congr. Soc. Ital. ORL Modena, 1978), wherein S presses a button, within a criterion time window, to a brief episode of frequency modulation in a pure tone. F was either 0.5, 1, or 2 kc/s at 40 db HL. An estimate of delta f/f for every test by the CTFD was printed out by the apparatus, while 4 indices of delta f/f by the ATFD were abstracted by hand from various features of the Bekesy-type tracings. Estimates of delta f/f by the CTFD were close to those of the classic study of Shower and Biddulph, but those by the ATFD were rather larger than reported in previous studies of pitch-memory. Student "t" tests revealed that only 5 of 24 comparisons between tests (4 ATFD variables vs 1 CTFD estimate X 2 ears X 3 frequencies) reached the 95% confidence level, while Pearson r's also showed little evidence of significant relationships between the two tests. While the CTFD yields a more precise delta f/f and has other virtues as a research tool, it demands 40-200 min to explore a listener's discriminability in both ears at 5 frequencies. Thus, although the ATFD yields less precise data, and has inherent within it the possibility of the intrusion of undesired psychological factors, it is to be preferred for clinical use since it demands only 15 min of experimental time.

Adult↗