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Biomedical subjects

F D Ernst

Publications and source records attributed to F D Ernst.

14 recordsLinked to original sources
PubMed1986

[Significance of hemodynamics and hemorheology in microcirculation disorders].

The angioarchitecture of the terminal vascular system and the rheologic properties of the flowing blood lead to its inhomogeneous distribution in the so-called microcirculation. Together with the spatial disproportion in the vascular pattern, a temporal inhomogeneity becomes quantitatively and qualitatively measurable with the help of intravital microscopy in animal experiments. Vasomotion in the precapillary vessels of resistance and further local regulation mechanisms are discussed, particularly the factors caused by blood fractions and their fluidity. The correlation between blood fractions, plasma and vascular wall is quantifiable by capillary microscopy with the help of dynamic morphometry. Useful consequences for prophylaxis and therapy are summarized in surveys.

Animals↗
PubMed1985

[Functional relations between microcirculation and oxygen supply (physiologic peculiarities in polarographic pO2 measurement in tissue)].

The measurement of the partial pressure of oxygen in the tissue is a method increasingly used in experiment and clinic, the technical prerequisites for this having been created by means of the development of polarographic measuring techniques (surface or scarifier-electrodes). The pO2-measurement of the tissue renders possible independent conclusions to the relations of microcirculation of the organs examined and to the effectiveness of the blood supply of the tissue as well as its homogeneity and nutritive achievement for the cellular metabolism. On the basis of the intravital microscopic findings in connection with perivascular pO2-measurement the pathophysiological peculiarities of this measuring method are discussed. The physiologically involved temporary and spatial inhomogeneities of the peripheral blood supply limit, however, the generalization of locally (approximately 200-300 microns3 measuring area) established oxygen values for diagnostics and therapy control. For the measurement an intact microcirculation and the simultaneous registration in several measuring places is necessary. Then the following informations may be obtained, e.g.: control of the exact dosage of an inspiratory O2-supply--control of the volume balance--control of the haemodynamic effect of drugs on the microcirculation.

Capillaries↗
PubMed1979

[Cryosurgical treatment of polypi of the rectum and colon (author's transl].

UNLABELLED: Single cases of genuine colon rectum polypi, histologically adenomatous, adeno-villous and villous tumours have been treated with cryosurgery. INDICATION: Relapses after polyectomy showing malignant degeneration; malignantly degenerated polypi, treatment of the basis of sessile lesions; sessile polypi up to 1 cm in diameter; extensive polyposis--polyposis of the rectum. After an initial regression of the polypous changes growth can be stated and quickly developing degenration leading to the formation of a carcinoma of the rectum and to stenoses of the lumen. It was only partially possible to clarify the cause of the growth in animal experiments. Primary application of low temperatures in polyposis recti and in primarily malignant degenerated polypi have to be avoided.

Cell Transformation, Neoplastic↗
PubMed1979

[Various cytological foundations and consequences of cryosurgery].

The methodically and strictly localized destruction of tissue presumes a precise knowledge of the physically conditioned and cytologically provable alterations after the influence of deep temperatures. According to generally effective principles of cold-biology it is referred to organspecific and functional-anatomic particularities which have to be considered in the cryosurgery.

Animals↗
PubMed1979

[The functional behavior of peripheral circulation in cryogenic surgery].

The reactive behaviour of little vessels of the circulatory periphery against the effect of extremely deep temperatures was examined in a sense of a microflow measurement by means of the intravital microcinematography. The results obtained by mathematical analysis of the single figure demonstrate that the vessels of microcirculation are remarkably resistant against rapid withdrawal of heat. In this way the quickly recovered blood-flow in the periphery of circulation can reduce detrimentally the time of tissue thawing treated by cryosurgery. Both the shortening of the thawing phase after cryosurgery conditioned by hemodynamics and the development of a cold edema can be met by experimentally confirmed adrenergic influence of the vasoconstriction under local anesthesia.

Animals↗