PubMed Health⌕ Search

Biomedical subjects

F D Frigoletto

Publications and source records attributed to F D Frigoletto.

At least 91 records · Page 5Linked to original sources
PubMed1986

In utero treatment of a fetus with diaphragmatic hernia complicated by hydrops.

A case of diaphragmatic hernia is reported where the prenatal diagnosis was made sonographically in a hydropic fetus and the large associated fluid collection in the right side of the chest was aspirated in utero. Almost complete drainage of the chest and abdominal fluid was accomplished, with resolution of the hydrops and no reaccumulation during the last 2 weeks of the pregnancy. After a spontaneous vaginal delivery, the infant was easily stabilized, and underwent operation in good condition.

Drainage↗
PubMed1986

Abnormal facial features and extremities in human trisomy syndromes: prenatal US appearance.

Twelve cases of fetal trisomy syndromes are reported in which prenatal sonographic findings were highly suggestive of the chromosomal abnormality. The abnormal appearance on the sonogram led to karyotype studies in ten fetuses and to appropriate obstetrical management. The sonographic abnormalities pertained to the extremities and face of the fetus.

Chromosome Aberrations↗
PubMed1986

Fetal respiratory movements: only part of the biophysical profile.

In a period of 1.5 years, approximately 1000 women with high-risk pregnancy received sonographic examinations in the authors' laboratory. Of these patients, five women with postterm pregnancy were found to have oligohydramnios and no other reassuring body or limb movements, despite the finding in each case of regular, sustained fetal respiratory movements. Four of the five neonates had evidence of fetal compromise at birth and the fifth had intrauterine growth retardation but good Apgar scores. The recurrence of the problem emphasizes the need to consider fetal respiration as only one part of the total biophysical profile.

Amniotic Fluid↗
PubMed1985

Sonographic diagnosis of Down syndrome in the second trimester.

We report a sonographic sign consisting of increased skin or soft tissue thickening at the back of the fetal neck during the second trimester, which correlates well with the diagnosis of Down syndrome. Eight hundred consecutive sonograms were performed in conjunction with genetic amniocentesis where four fetuses had trisomy 21 (Down syndrome) by karyotype. Two or 50% had sonographic findings consistent with Down syndrome. Recently we described a retrospective series where 904 sonograms were performed at the time of amniocentesis and seven fetuses had trisomy 21 on cytogenetic analysis. The abnormal sonographic finding at the back of the neck was present in three of those seven cases. Combining these series, 1704 fetuses were examined and 11 cases of Down syndrome were diagnosed cytogenetically. Five of the 11 or 45% had an abnormal sonogram suggestive of Down syndrome. Two of these were patients undergoing sonography for ascertainment of dates at 16 weeks and submitted to amniocentesis solely on the basis of this sonographic finding.

Amniocentesis↗
PubMed1985

Sonographic sign for the detection of early fetal ascites in the management of severe isoimmune disease without intrauterine transfusion.

Ultrasonography is an important adjunct to the delta optical density at 450 nm in the management of isoimmunized pregnancies. We describe a sonographic finding that we believe is the earliest sign of fetal ascites suggesting decompensation. In this patient, despite high measurements of delta optical density at 450 nm, intrauterine therapy or delivery was delayed for more than 7 weeks by careful sonographic monitoring.

Adult↗
PubMed1985

Sonographic findings in severe preeclampsia twenty-four hours prior to clinical signs.

We describe a patient who had abnormal sonographic findings of the liver 24 hours before signs and symptoms of severe preeclampsia and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). The abnormal sonographic appearance of the liver prompted further investigation and was instrumental in the management of this case.

Adult↗
PubMed1985

Prenatal ultrasound diagnosis of clubfoot.

Five cases of congenital clubfoot diagnosed prenatally by ultrasound are reported. The incidence of clubfoot may be higher within an affected family and may be associated with other structural anomalies or chromosomal abnormalities. Identifying a clubfoot in utero should therefore alert the sonographer that other anomalies may be present and should lead to a detailed structural survey.

Abnormalities, Multiple↗
PubMed1985

The management of preterm labor with the calcium channel-blocking agent nifedipine combined with the beta-mimetic terbutaline.

We describe a successful, prolonged, inhibition of preterm labor using nifedipine combined with terbutaline in a patient undergoing complicated obstetrical problems. Delivery was delayed for two months and no significant ill effects were observed in the mother or her infant. This case reports the longest duration and the safe use of nifedipine for tocolysis, to date. A review of reports of the use of calcium channel-blockers in preterm labor is also presented.

Adult↗
PubMed1985

Elevated beta-human chorionic gonadotropin and testosterone in cord serum of male infants of diabetic mothers.

Leydig cell hyperplasia is a common histological finding in male infants of diabetic mothers. The functional correlates of this histological finding were investigated by measuring beta hCG, testosterone, androstenedione, dihydrotestosterone, and progesterone in mixed cord serum of male and female infants of diabetic mothers (n = 40) and normal mothers (n = 40) at term. Male and female infants of diabetic mothers had significantly higher cord serum beta hCG levels than male and female controls. Male infants of diabetic mothers had significantly higher cord serum testosterone concentrations than male controls, female controls, and female infants of diabetic mothers. Cord serum testosterone concentrations were similar in female infants of diabetic mothers and female controls. In the male infants of diabetic mothers, there was a significant positive correlation between beta hCG and testosterone (r = 0.64; P less than 0.01). There was no significant correlation between beta hCG and testosterone in the male controls (r = -0.15; P = NS). There was no significant difference in cord serum dihydrotestosterone in any group tested. Cord serum progesterone was significantly higher in the males than in the females. Cord serum androstenedione was lower in the infants of diabetic mothers than in the controls. This study suggests that the Leydig cell hyperplasia found in male infants of diabetic mothers is due, in part, to elevated concentrations of hCG and is accompanied by elevated testosterone concentrations in the fetal compartment.

Androstenedione↗
PubMed1985

Antenatal sonographic diagnosis of fetal gastrointestinal malformations.

Fetal gastrointestinal abnormalities are readily detected by ultrasonography. The presentation, management, and outcome of 17 cases of fetal gastrointestinal and associated anomalies are presented. Antenatal knowledge of these abnormalities can potentially decrease neonatal morbidity and mortality because the appropriate preparations can be made in advance of delivery.

Adult↗
PubMed1985

Ultrasonographic determination of chorion type in twin gestation.

Reported are sonographic criteria for distinguishing the chorionic type of twin pregnancies prenatally. Thirty-four twin pregnancies were prospectively evaluated with correct assignment of chorionic type in 33 cases. The ability to determine the chorionic type of twin gestation facilitated the prenatal diagnosis and management in eight of the studied cases. Knowledge of the type of twinning antenatally is important in the management of twin pregnancies.

Amnion↗
PubMed1985

Stillbirth after nonstress testing.

The authors' experience with stillbirth within one week of a reactive nonstress test was reviewed to determine the reliability of this test in postdates patients and general high-risk patients. The corrected stillbirth rates were the same in both groups. Thirty-three percent of stillbirths in postdates patients occurred as early as 41.5 weeks' gestation. The cause of stillbirth in postdates patients was not clear even after careful autopsy. In the general high-risk group, 60% of stillbirths were due to an acute event with the remainder due to chronic fetal compromise that was not predicted by the nonstress test. Induction at 41.5 weeks' gestation or more comprehensive fetal surveillance than weekly nonstress testing are possible approaches to the management of postdates pregnancy, which need to be further studied.

Exercise Test↗
PubMed1985

Use of the subcutaneous heparin pump during pregnancy.

Six patients requiring anticoagulation during pregnancy were managed with a continuous-infusion subcutaneous heparin pump. There were no cases of recurrent thrombosis; however, five of the six patients had major or minor bleeding complications despite therapeutic partial thromboplastin time levels.

Adolescent↗
PubMed1984

The fetal face: ultrasound examination.

Abnormalities of the fetal face were identified by ultrasound in five cases. Abnormalities such as cleft lip and palate, cyclopia, and forms of holoprosencephaly were diagnosed prenatally. Two of the fetuses had trisomy 13. When facial abnormalities are identified a careful search of the fetus for associated anomalies is indicated; amniocentesis for genetic study may be desirable. In addition, evaluation of the fetal face may be useful when other fetal abnormalities are present.

Cleft Lip↗
PubMed1984

Second trimester oligohydramnios, a predictor of poor fetal outcome.

Twelve cases of severe second trimester oligohydramnios are reported. The outcome of these pregnancies was uniformly poor, with no survivors in the present series. Four patients had therapeutic abortions, one woman had spontaneous labor at 22 weeks' gestation, and seven patients continued to viability. Of these, five patients had severe renal abnormalities incompatible with life. Two infants died at, or shortly after, birth from severe intrauterine growth retardation (IUGR), one of which had a triploid karyotype. Review of the literature shows a similar poor outcome for pregnancies with severe oligohydramnios in the second trimester.

Abnormalities, Multiple↗