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Biomedical subjects

F D Goebel

Publications and source records attributed to F D Goebel.

At least 217 records · Page 12Linked to original sources
PubMed1981

Short term changes of glycosylated haemoglobins during glucose administration in healthy and diabetic subjects.

Haemoglobin A1 (Hb A1) is becoming a routine parameter for monitoring diabetic metabolism. Although widely used, the kinetic relationship between glucose concentration and Hb A1 value is not clarified yet. In vivo biosynthesis of Hb A1 was studied in 30 patients during an oral glucose tolerance test. Ten diabetics received an i.v. injection of 0.5 g glucose/kg, 20 healthy students and infusion of 1.0 g and 1.5 g glucose/kg and hour for 6h, and six volunteers 2.0 g/kg and hour. A parallel increase and decrease of serum glucose levels and Hb A1 could be demonstrated beginning a few minutes after administration of glucose. These acute changes of Hb A1 are closely related to fluctuation of serum glucose probably representing the formation and dissociation of the labile aldimine-linkage between haemoglobin and glucose. Severe hyperglycaemia of 6 h duration is not sufficient to cause an elevation of stable glycohaemoglobin.

Diabetes Mellitus↗
PubMed1981

[Wegener's granulomatosis: an example for the collaboration between the specialist for otorhinolaryngology and internal medicine (author's transl)].

Diagnosis, treatment and follow-up of patients with Wegener's Granulomatosis is described as an example for the collaboration between the specialist for otorhinolaryngology and internal medicine. In all cases reported a muco-sanguinous rhinitis was the first manifestation of the disease. All patients presented lung involvement while the kidneys were involved in 75%. As histologic examination does not always give a pathognomonic feature, diagnosis has to be made relying on clinical data and natural course of the disease. Cyclophosphamide in combination with corticosteroids is the treatment of choice. This treatment has considerably improved the previously unfavorable prognosis of this disease. A long term follow-up of patients with Wegener's Granulomatosis by specialists for otorhinolaryngology and internal medicine seems to be absolutely necessary.

Adolescent↗
PubMed1980

[Possibilities of longterm monitoring of metabolic diseases (author's transl)].

The measurement of glycolysed hemoglobin as a parameter of longterm monitoring has considerably enlarged the scope of possibilities for diabetic supervision. Retrospective information on the quality of the metabolic stabilization up to three months is possible, independently of the momentary blood sugar. Analyses of fatty tissue permit conclusions on the fat composition of the diet in the past years, the fatty acid pattern of the cholesterol esters are an indicator for the ingestion of unsaturated fatty acids in the last few weeks. No practicable method for longterm monitoring of purine metabolism has yet been developed. The size of the uric acid pool may be such a parameter.

Adipose Tissue↗
PubMed1978

[Juvenile gout with decreased activity of hypoxanthine-guanine-phosphoribosyl transferase and pheochromocytoma: partial persistence of tophi despite uric-acid reducing treatment for 12 years (author's transl)].

A now 45-year-old man with marked chronic tophous gout and recurrent nephrolithiasis has been followed for 12 years. First gouty symptoms appeared at age 18. Uric-acid reducing treatment freed the patient of symptoms, and bony and soft-tissue tophi in part regressed. The early onset and high urinary uric-acid excretion indicated increased uric-acid production. Decreased activity of the enzyme hypo-xanthine-guanine-phosphoribosyl transferase was demonstrated to be the cause of the hyperuricaemia, which led to an excessive purine synthesis. An almost complete loss of activity of this enzyme is the basis of the Lesch-Nyhan syndrome. In the described patient all of the neurological and behavioural disorders of the Lesch-Nyhan syndrome were absent. A pheochromocytoma was found to be the cause of malignant hypertension, which had been present for many years.

Adrenal Gland Neoplasms↗
PubMed1977

Muscle capillary basement membrane thickness in lipoatrophic diabetes.

A 21 years old female patient with lipoatrophic diabetes, a distinct syndrome of insulin resistant diabetes mellitus, loss of subcutaneous fat, hepatosplenomegaly, hyperlipidemia, increased basal metabolic rate, subvalvular aortic stenosis and cystic bone lesions is described. She exhibited all clinical signs of diabetic microangiopathy. Quantitative estimation revealed severely thickened basement membranes of muscle capillaries. It is concluded that the extent of her microangiopathy is a consequence of her excessive metabolic abnormalities.

Adult↗
PubMed1977

Levamisole-induced immunostimulation in spondylarthropathies.

The term "seronegative spondylarthritis" (S.S.A.) has been assigned to rheumatic disorders with closely related clinical features, defined by seronegativity and HLA-B27 phenotype. Its pathogenesis may be linked with a genetically controlled defective immune response. Therefore, 37 men with S.S.A. were treated with levamisole (150 mg/day, 3 days/wk) to stimulate the immune reactions. In a randomised controlled crossover study these patients also received a placebo; each period ran for 12 wk. Symptomatic therapy was continued through the entire 6 mo. Serious side-effects led to withdrawal of the active drug in 9 patients. Clinical response was measured in terms of a cumulative joint index, spondylometry, morning stiffness, and a pain scale. Treatment with levamisole resulted in a significant improvement in these parameters. Radiological evidence of sacroiliitis was present in 48.6% before and after levamisole, and joint scanning with 99Tc-pyrophosphate also revealed no progress in the disease. After levamisole treatment, IgM levels fell significantly (P less than 0-014). Likewise, the previously high percentage of antibodies with weak cytotoxic activity against lymphocytes was reduced after levamisole (P less than 0-049), and an increased rate of leucocyte-migration inhibition (L.M.I) was found in the levamisole-treated group. Thus, the immunostimulating properties of levamisole may interfere with defective immunoregulation in S.S.A. and, by improving the clinical conditions, lead to a change in the course of this disease.

Adult↗
PubMed1977

Red cell metabolic and membrane features in haemolytic anaemia of alcoholic liver disease (Zieve's syndrome).

Zieve's syndrome (ZS), which consists of transient haemolytic anaemia, jaundice, hyperlipoproteinaemia, and alcohol-induced liver disease, was studied in male patients during the acute (n = 20) and the remittent (n = 10) phase. Chronic alcoholics (n = 10) without haemolysis and healthy male persons (n = 10) served as controls. Erythrocytes were separated into old and young cells by means of density-layer centrifugation. Those fractions which contained older red cells disclosed a pyruvate-kinase instability which resulted in impaired metabolism. Changes in membrane lipid composition as indicated by increased cholesterol and polyunsaturated fatty acids (PUFA) were also detected in patients during the acute phase of ZS. Alcohol-induced red-cell vitamin-E deficiency with a decrease in PUFA levels may provoke an oxidation of reduced red-cell glutathione which in turn results in the enzyme instability. This study lends further support to the hypothesis that the putative role of the red-cell metabolic injury in the origin of haemolysis in ZS cannot be envisaged without introducing membrane-linked and extracellular cofactors.

Adult↗
PubMed1976

[Use of muscle aspiration biopsy needle for diagnostic purposes].

The needle for aspiration biopsy of skeletal muscle, previously developed for biochemical and physiological purposes, has been introduced in the diagnosis of muscular and vascular diseases. Evidence is presented that this needle is a useful tool for routine evaluation of such disorders.

Biopsy, Needle↗
PubMed1975

Haemolytic anaemia with hereditary pyruvate kinase instability developing acute leukaemia.

The case of a 27-year-old woman with pancytopenia, revealing acute monocytic leukaemia and haemolytic anaemia, is described in detail. The underlying cause for the red cell destruction was found to be a pyruvate kinase (PK) instability. Further investigation into three generations of her family (n = 12) disclosed a hereditary PK instability. This was proven by performing biochemical studies to elucidate mutants representing a structurally defective enzyme. Since conversions of pancytopenia with acquired red cell enzyme deficiency into leukaemia have been described, our observation emphasizes that hereditary red cell enzymopathy might also be associated with adult acute leukaemia.

Adenosine Triphosphate↗
PubMed1975

Adaptation of red cell enzymes and intermediates in metabolic disorders.

The metabolic activity of the red cell glycolytic pathway hexose monophosphate shunt (HMP) with dependent glutathione system was studied in patients with hyperthyroidism (n = 10), hyperlipoproteinemia (n = 16), hypoglycemia (n = 25) and hyperglycemia (n = 23). In uncontrolled diabetics and patients with hyperthyroidism the mean value of glucose phosphate isomerase (GPI), glucose-6-phosphate dehydrogenase (G-6-PD), glutathione reductase (GR) was increased, whereas these enzyme activities were reduced in patients with hypoglycemia. Apart from a few values of hexokinase (HK) which were lower than normal the results in hyperlipoproteinemia patients remained essentially unchanged, including the intermediates such as 2,3-diphosphoglycerate (2,3-DPG), adenosine triphosphate (ATP) and reduced glutathione (GSH). While increased rates of 2,3-DPG and ATP in hypoglycemia patients were obtained, these substrates were markedly reduced in diabetics.

Diabetes Mellitus↗