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Biomedical subjects

F D Pien

Publications and source records attributed to F D Pien.

At least 19 recordsLinked to original sources

Tuboovarian abscess caused by Edwardsiella tarda.

Edwardsiella tarda infections are uncommon and have often been reported in association with pet reptiles. The majority of these infections occur as gastrointestinal disorders in immunocompromised hosts. We believe this to be the first reported American case of tuboovarian abscess caused by this organism in an otherwise healthy woman whose only known exposure was to raw seafood. This patient had fever and lower abdominal pain caused by a severe Edwardsiella tarda pelvic abscess that required surgical drainage and intravenous antibiotics for complete recovery.

Abdominal Pain

Septic bursitis: experience in a community practice.

We reviewed 47 episodes of septic bursitis occurring in a private community medical practice. Most patients were male (85%), and roughly half (49%) the cases were related to recreational or occupational trauma. About 72% of cases were located in the olecranon bursa, while the remaining cases were prepatellar. Prepatellar bursitis patients were more likely to be hospitalized. Staphylococcus aureus was isolated from 70% of bursal fluid aspirations; other etiologic organisms included gram negative bacteria and Mycobacterium marinum. The majority of patients were able to be treated as outpatients with oral antibiotics. All patients were eventually cured without serious complications.

Adolescent

Bacterial endocarditis at a small community hospital.

Clinical features, microbiology, and predisposing factors are described in 56 patients with bacterial endocarditis (BE) treated over a 12-year period at a small community hospital in Hawaii. The average age of patients was 52.0 years. The mean duration of symptoms was 28.8 days (range 1 to 240 days). Streptococci was the most frequently identified causative organism, present in 61% of the cases. Gram-negative bacilli were isolated from six patients (11%). Fourteen patients (25%) required cardiac surgery; the most common condition leading to surgery was severe valvular insufficiency, followed by congestive heart failure and recurrent embolism. Eighty-two percent of the patients in the series survived. The leading causes of death were congestive heart failure and cerebrovascular accidents.

Adult

Eosinophilic pleural effusions.

We present 2 cases of eosinophilic pleural effusion (EPE) seen recently at Straub Hospital. One occurred in a patient with pneumococcal empyema; the 2nd patient had 2 episodes of EPE secondary to malignant histiocytic lymphoma. Eosinophilic pleural effusion (EPE) is defined as having eosinophils exceeding 10% of the pleural fluid WBC differential. EPE is usually exudative, typically accounting for 1% to 8% of all pleural effusions. Up to 30% to 35% of EPE are idiopathic, while other frequent causes include air in the pleural space (30%), and pulmonary infections (10%). Collagen vascular diseases, tuberculosis and malignancies are common causes of EPE. Although spontaneous resolution and a favorable prognosis predominates in this entity, prudent clinical follow-up is advised. Since the first documented case of eosinophilic pleural effusion in 1984 by Harmsen, clinicians have attempted to determine its significance. This condition is defined as pleural effusion with greater than 10% of the WBC differential eosinophils. We saw 2 cases of EPE at Straub Hospital during 1988.

Eosinophilia

Insulin-dependent diabetes mellitus associated with pentamidine.

Insulin-dependent diabetes mellitus occurred following intravenous pentamidine treatment of two AIDS patients with Pneumocystis carinii pneumonia. Both patients also experienced drug-induced nephrotoxicity. Patients receiving pentamidine must be observed for multisystem dysfunction, including the onset of severe diabetes mellitus. Dosage adjustment or alternative therapy should be considered with the onset of toxicity.

Adult

Vibrio vulnificus infection in Hawaii.

A life-threatening Vibrio vulnificus infection occurred in a 52-year-old Korean woman with hepatic cirrhosis. Four days after ingesting raw crab, the patient presented to the hospital with nausea, vomiting, fever, hypotension, and hemorrhagic blistering of the left foot. Vibrio vulnificus was recovered from both her blood and a foot wound.

Female

AIDS affects all.

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Acquired Immunodeficiency Syndrome

Marine-acquired infections. Hazards of the ocean environment.

Numerous pathogenic bacteria are found in seawater. They can cause several environmental infections, such as conjunctivitis, otitis externa, wound infections, pneumonia, and gastrointestinal illness. The incidence of some of these infections could be lowered if people took care to avoid eating undercooked seafood, swimming in brackish water, or sustaining lacerations in a marine environment. However, such infections will probably increase in frequency as more people visit ocean resorts. Prompt elimination of the infective agent, adequate wound care, and avoidance of reexposure can minimize the severity of the condition.

Bacterial Infections

HTLV-III infection. A clinical approach to diagnosis and treatment of the 'AIDS virus'.

The retrovirus human T cell lymphotropic virus type III (HTLV-III) can cause no symptoms at all, a syndrome of vague symptoms such as fever and fatigue, or full-blown acquired immune deficiency syndrome (AIDS). Serologic tests for antibodies to HTLV-III are available for identifying the virus; tests for T lymphocyte subset numbers and function and white cell count are also helpful. Management of patients with the virus depends on clinical presentation: Patients who are asymptomatic carriers need only reassurance and follow-up, patients with mild illness need symptomatic treatment and monitoring, and patients with full-blown AIDS need increasing levels of physical and emotional supportive care. Through early diagnosis, treatment when needed, and patient education, primary care physicians can be instrumental in curtailing the spread of HTLV-III infection.

AIDS-Related Complex

Nosocomial Ewingella americana bacteremia in an intensive care unit.

Between Dec 8, 1982, and Jan 29, 1983, four cases of primary bacteremia with Ewingella americana occurred in the intensive care unit of a community hospital. The patients developed high fever and leukocytosis, which gradually resolved after institution of antibiotic therapy. All infected patients had undergone either cardiovascular or peripheral vascular surgery. Epidemiologic investigation revealed that the probable source for the Ewingella outbreak was contamination of the ice bath used to cool syringes for cardiac output determinations. The nosocomial outbreak was terminated by the introduction of a closed cardiac output injectate delivery system.

Cardiac Output

Salmonella dublin neck abscess.

Salmonella dublin infection is usually a veterinary disease. However, human outbreaks have occurred, mostly following consumption of contaminated raw milk. Salmonella dublin has a predilection for the immunocompromised host and usually causes a severe illness with fever, diarrhea, and bacteremia.

Abscess

Colonization of human wounds by Escherichia vulneris and Escherichia hermannii.

In this report we present clinical descriptions of 12 Hawaiian patients from whom Escherichia vulneris or E. hermannii strains were isolated. All but two patients had soft-tissue infections with multiple bacteria, particularly Staphylococcus aureus. The other two had purulent conjunctivitis associated with S. aureus and infected malignant peritonitis with multiple organisms, respectively. In none of the cases were the Escherichia spp. found in abundant quantities or considered pathogenic. In preliminary animal pathogenicity studies, 12 strains each of E. vulneris and E. hermannii failed to cause serious symptoms in 4-week-old mice when 10(7) cells were injected intraperitoneally. When 10(6) cells were used, none of these bacterial strains injected into mouse soft tissue was capable of producing persistent wound infections. Susceptibility studies of 40 strains of these bacteria to 20 different antimicrobial agents showed that they were susceptible to third-generation cephalosporins as well as to most other cephalosporins, aminoglycosides, trimethoprim, and sulfamethoxazole-trimethoprim; these strains were only marginally susceptible or resistant to penicillin, tetracycline, chloramphenicol, and nitrofurantoin.

Adult