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Biomedical subjects

F D'Ermo

Publications and source records attributed to F D'Ermo.

At least 19 recordsLinked to original sources
PubMed1979

A critical analysis of the long-term results of trabeculectomy.

We analyzed the long-term results of trabeculectomy in a homogeneous group of 90 eyes (75 patients) followed up one to five years after surgery. The effect on intraocular pressure was considered stable after one year; complete success was achieved in 69 (71%) of cases with a further in 8 (9%) partial success in eight (9%). The pressure-lowering effect was closely related to the presence of a filtering bleb. The main complication was the late appearance of lens opacities, although these seemed less frequent than after other antiglaucoma operations. Lens opacities were particularly frequent in hypotonic eyes and may depend upon the process of aqueous humor filtration itself.

Adolescent↗
PubMed1979

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.

Animals↗
PubMed1978

Immunopathology of the lens. II. 86Rb efflux and protein leakage from normal lenses exposed to antilens and antiuveoretina antibodies.

Normal rabbit lenses exposed in vitro to heterologous antilens and antiuveoretina antibodies lose control of the intracellular 86Rb and this effect is followed by a late leakage of lenticular proteins; both phenomena take place only in the presence of complement. This antibody-induced complement-dependent membrane damage might be involved in the pathogenesis of complicated cataracts in uveitis and in the self-maintenance of recurrent uveal inflammations.

Animals↗
PubMed1977

Immunopathology of the lens. I 86Rb efflux and protein leakage from normal lenses exposed to unrelated antigen-antibody interactions.

Normal rabbit lenses exposed in vitro to heterologous antibody (Ab)--antigen (Ag) interactions lose control of the intracellular 86Rb; this membrane damage, which seems to be related to the quantitative ratio Ab/Ag, is relatively complement independent and is followed by a subsequent leakage of lenticular proteins. A possible implication of these findings in the development of complicated cataracts in uveitis (as 'permeability cataracts') and in the self-maintenance of recurrent uveal inflammation is shortly discussed.

Animals↗
PubMed1977

[Phospholipase A and lysophosphatidylcholine in the pathogenesis of "permeability cataracts" (author's transl)].

Phospholipase A and Lysophosphatidylcholine (LPC) have been shown harmful for normal lens permeability, inducing an efflux of intracellular macromolecules in organ cultures. These findings, superimposible to what has been shown in the lens for complement-dependent immune damage, along with the hypothesis that the cytotoxicity of complement is mediated by a phospholipase, are considered relevant as far as the pathogenesis of complicated cataracts in "immune" uveitis and the selfmaintenance of recurrent autoimmune (to lens proteins) anterior uveitis are concerned.

Animals↗