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Biomedical subjects

F Dalet

Publications and source records attributed to F Dalet.

28 records · Page 2Linked to original sources
PubMed1978

Treatment of renal tuberculosis. II. Microbiological study of 271 renal tuberculous cavities.

271 renal cavities from 94 nephrectomies were studied with fluorescence stain and Lowenstein-Jensen medium cultures. The degree of the sterilization of the lesions is demonstrated by the existence of Koch's bacilli into the cavities. The latter have been classified in different development stages according to their contents and the histological aspect of the wall. The results of this study showed that a reduced healing time allows a better conservation of the parenchyma. The in vivo rifampicin + isoniazid + ethambutol association produces the best and quickest stabilization of the cavities.

Ethambutol↗
PubMed1977

Pharmacokinetics of fosfomycin during hemodialysis.

A study was made of the elimination of fosfomycin by the membrane of the artificial kidney in 10 patients with hemodialysis and a creatinine clearance of less than 5 ml/min. To do so we determined the half-life, the dialysance, the percentage of total loss and the percentage of loss by the artificial kidney. We reached the conclusion that fosfomycin is heavily dialyzed (D = 64 ml/min), it is entirely eliminated by the kidneys and its half-life is therefore affected very little (an increase of only about 30 min is produced). All of this leads to a practical schema by which the entire initial dose should be replenished at the end of each dialysis.

Anti-Bacterial Agents↗
PubMedDate not supplied

Cephalexin concentration in the human ejaculate following oral and parenteral administration.

Cephalexin levels in the ejaculates of 31 infection-free volunteers have been determined following the administration of 1 g of antibiotic. In 16 subjects the cephalexin was administered by intramuscular injection and in 15 by mouth. In each case the volunteers were divided into groups of five each of which received the drug, 1, 2 or 4 hours before the collection of semen. Antibiotic concentrations were determined microbiologically on agar plates using Sarcina lutea ATCC 9341. For selection purposes healthy subjects were considered to be those showing a normal anamnesis and physical exploration, an absence of leucocytes demonstrable by a cytomorphological evaluation of the semen, semen citric acid and fructose levels within normal limits and a qualitatively and quantitatively similar saprophytic flora to that seen in a culture of urine taken immediately before the collection of semen. Maximum concentrations were obtained 2 hours after the administration of the antibiotic and the concentration following intramuscular injection (6.9 microgram/ml) was significantly greater than that following oral administration (4.7 microgram/ml).

Administration, Oral↗