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Biomedical subjects

F Danner

Publications and source records attributed to F Danner.

5 recordsLinked to original sources
PubMed1996

Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients.

The apolipoprotein E genotype and cortical senile plaque (SP) and cortical and hippocampal neurofibrillary tangle (NFT) densities were determined in non-demented individuals and neuropathologically confirmed AD patients. The non-demented population was further subdivided according to presence or absence of pathologically established critical coronary artery disease (cCAD), hypertension (HyperT), or neither (non-heart disease; non-HD). The apolipoprotein E4 (APOE4) allele incidence and dose frequencies were increased in the AD, cCAD and HyperT groups compared to the non-HD controls. The mean number of SP and NFT was significantly increased with the presence of the APOE4 allele within the entire population. After grouping the non-demented subjects according to cardiac status, SP but not NFT density was increased among those individuals with the APOE4 genotype. In HyperT, the increased density of SP also correlated to the APOE4 allele dose frequency. The density of SP and NFT was increased in all regions of AD brain compared to all other non-demented groups, but no significant difference was found between AD patients with or without an APOE4 allele. These two AD groups were age-matched, but could not be matched for disease duration. The data suggest a relationship between heart disease, APOE4 genotype and the presence of SP regardless of cognitive status.

Aged↗
PubMed1990

The measurement of physical activity in young children.

Two studies were conducted to determine the validity of various measures of physical activity in young children. In Study 1, 21 preschool children were utilized to explore how well measures of children's activity obtained from parents, teachers, and the children predicted observed behavior at school and in the home. Study 2 (n = 51 preschool children) focused on the predictive validity of the Caltrac motion sensor. In both studies, detailed minute-by-minute ratings of children's activity in Study 1 were generally ineffective in predicting observed physical activity. Children's activity preferences, however, were significantly related to the proportion of high intensity physical activity performed. In Study 2, there was a significant relationship (r = .86, p less than .0001) between Caltrac readings and observed physical activity. This correlation was similar for boys and girls, normal and overweight children, and younger and older children. These findings suggest that the Caltrac monitor may provide a valid index of individual differences in physical activity in young children.

Child Behavior↗
PubMed1987

Effects of physical conditioning on information-processing efficiency.

This study investigated changes in information-processing efficiency that occur when physical fitness improves. Information-processing variables were Sternberg's memory-scan rate, Posner's name-access time, the Cattell Culture Fair Intelligence Test, and numbers of words remembered from word lists. At present and posttest 10 to 12 wk. later, 66 adults between the ages of 18 and 48 yr. took all cognitive tests and rode a bicycle ergometer to estimate physical fitness. A 2 X 2 (improved/stable fitness groups by pretest/posttest trials) analysis of variance with repeated measures indicated that the group who improved 15% or more in physical fitness improved significantly more on the name-access time than the group whose fitness remained stable. There was a trend toward improvement in memory-scan rate and number of words remembered on the first word trial by people who became more fit. The results may have implications for assessment and training of personnel in occupations where speeded perception and responses are required.

Adolescent↗
PubMed1979

Changes with age in measures of processing efficiency.

Children of 3 ages (8, 10, and 12 years) and adults were asked to decide rapidly whether 2 line drawings were same or different based on either physical appearance (physical match) or name information (name match). Reaction times were used to estimate several temporal measures of information-processing efficiency, such as the difference between different and same judgments, the difference between name-match and physical-match judgments, and 2 types of interference. Different judgments required more time than same judgments for children but not for adults, and the difference between these decreased with age. As expected, name judgments required more time than physical judgments, but the difference did not decrease regularly with age. Interference in name-match decisions due to conflicting and irrelevant physical information decreased with age; however, interference in physical-match judgments due to conflicting and irrelevant name information does not decline with age and was a significant factor in the performance of older children and adults. The results underscore the complex character of developmental change in processing efficiency.

Adolescent↗