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F De Martino

Publications and source records attributed to F De Martino.

16 recordsLinked to original sources
PubMed1996

[Biliary scintigraphy vs. ultrasonography in the etiological diagnosis of acute pancreatitis].

Etiology of acute pancreatitis has important implications in the treatment of the disease as gallstones pancreatitis requires the correction of the underlying biliary disease. The usefulness of ultrasonography in the detection of stones in emergency has been questioned, and HIDA biliscintigraphy has been reported to be a possible indicator of biliary pancreatitis. This study compares the value of HIDA colesscintigraphy and ultrasonography in the etiologic diagnosis of 35 patients admitted and treated for acute pancreatitis in our Institution. All patients underwent ERCP for the confirmation of the findings. Cholescintigraphy showed no visualisation of the gallbladder, suggesting biliary tract stones, in 25 patients. In all of them ERCP confirmed the presence of gallbladder and/or common bile duct stones, and endoscopic sphincterotomy and later elective cholescystectomy was performed. Ultrasonography failed to demonstrate biliary stones in 11 of those patients. HIDA cholescintigraphy showed a sensitivity and a negative predictive value of 1 vs 0.56 and 0.45 for ultrasonography. From the results of our study it can be concluded that HIDA biliscintigraphy is more reliable than ultrasonography in the discrimination of biliary vs non-biliary acute pancreatitis in emergency.

Acute Disease↗
PubMed1994

Coordination and spin state equilibria as a function of pH, ionic strength, and protein concentration in oxidized dimeric Scapharca inaequivalvis hemoglobin.

The oxidized homodimeric Scapharca inaequivalvis hemoglobin undergoes changes in coordination and spin state as a function of pH, ionic strength, and protein concentration which have been monitored by optical absorption spectroscopy. Three species contribute to the spectra between pH 5.8 and 8.7: (i) a hexacoordinate high spin aquomet derivative, whose concentration is essentially constant over the whole pH range analyzed; (ii) a pentacoordinate high spin component which prevails at alkaline pH values, and (iii) a hexacoordinate low spin hemichrome, which is formed at acid pH. The contribution of each of the components to the observed spectra was calculated with the singular value decomposition procedure and has been described quantitatively in terms of a linkage scheme which accounts for the change in heme coordination and for the observation that the high spin to low spin transition entails dissociation into monomers. An important feature of the linkage scheme is the cooperative binding of protons to aquomet dimers. Stopped flow experiments to study the kinetics indicate that dissociation into monomers is the rate-limiting process. The unusually strong tendency of oxidized HbI to loose the heme-bound water molecule is discussed in terms of strain in the iron-proximal histidine bond.

Animals↗
PubMed1993

[L-T4 malabsorption determined by intolerance to cow's milk proteins and celiac disease in a patient with congenital hypothyroidism. A clinical case].

An infant with congenital hypothyroidism (CH) is described who in the course of thyroxin replacement therapy developed cow's milk protein intolerance (CMPI) and subsequently coeliac disease (CD). The presence of these two pathologies interfered with the intestinal absorption of L-thyroxin (L-T4) and made the appropriate management of CH difficult. A male patient, formula fed from birth, was screened for CH at 5 days of age. CH was confirmed and L-T4 treatment (6.8 micrograms/kg/day per os) begun at 35 days of age. Seen after 3 weeks because of feeding problems and impaired growth and with a serum T4 concentration of 4.7 micrograms/dl and a TSH of 56 mU/ml, his replacement dose was increased to 12 micrograms/kg/day. One week later, the child was hospitalized because of vomiting, acidosis and shock. CMPI was diagnosed and the child began a diet with a hydrolyzed milk protein food. After 7 weeks the serum T4 improved to 11 micrograms/dl, the TSH decreased to 10 mU/ml, while maintaining the 12 micrograms/kg dose. After 2 months an oral challenge with cow's milk confirmed the diagnosis of CMPI with a concomitant decrease in serum T4 to 6.4 micrograms/dl, while TSH rose to 64 mU/ml. Weight and T4 levels normalised with CMPI diet. At 12 months of age the patient presented anorexia and impaired growth.(ABSTRACT TRUNCATED AT 250 WORDS)

Celiac Disease↗
PubMed1984

Gorham syndrome.

Explore the source record for details and available documents.

Adolescent↗
PubMed1983

[Erythrocyte deformability in subjects with microangiopathy caused by vibrating tools].

A research on hemorheological and microvascular behavior with regard to the red blood cell filterability determined by the Teitel-Reid-Dormandy technique has been performed on 15 subjects with microangiopathy due to vibrating tools, who were hospitalized at the Work Medicine Institute of the 2nd Medical Faculty of Naples University. The results pointed out an increase of filtration times and a consequent decrease of blood flow, as opposed to the control group. As a conclusion of the research, the authors were in the opinion that in the vibrating tool syndrome, in addition to the hemodynamic elements, the hemorheological components of the microcirculation should also be primarily evaluated alongside red blood cell filterability.

Adult↗
PubMed1983

[Combined instrumental evaluation of microangiopathy caused by vibrating tools].

A clinico-instrumental study has been carried out on 15 subjects who had been hospitalized for microangiopathy due to vibrating tools at the Work Medicine Institute of the 2nd Medical Faculty of Naples University. Various instrumental methods (in vivo nailbed microscopy, conjunctival biomicroscopy, finger photoplethysmography, hand-contact thermography) were employed. As a conclusion of the research and from the obtained results it is assumed that the evaluation of the various methods, as far as the microangiopathy due to vibrating tools is concerned, should be performed in a critical and exhaustive way. However, the in vivo nailbed microscopy integrated by conjunctival biomicroscopy seems to represent the most sensitive indicator of microcirculatory disorders in differentiating conditions of general microvascular pathology and for a more precise diagnosis and appropriate therapy.

Adult↗
PubMed1980

[Effects of pentobarbital on serum levels of LH and FSH, in normal conditions and after GnRH stimulation: preliminary report].

The authors have tested serum levels of LH and FSH in healthy males anaesthetized with 20 mg/Kg body weight of pentobarbital, and stimulation test with GnRH. LH has reached levels higher than the stimulation test has been practised in the anaesthetized volunteers than in subjects awakes. The AA. have also showed that there is no effect on psychic stress and of atropine, used as preanaesthetic drug, on serum levels of the pituitary hormones. At the end, PB has no effect on serum levels of FSH.

Adult↗