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Biomedical subjects

F De Romanis

Publications and source records attributed to F De Romanis.

17 recordsLinked to original sources
PubMed1997

[Felbamate: a long-term study in subjects with refractory epilepsy].

UNLABELLED: 18 patients with refractory complex partial seizures with or without secondary generalization resistant at common AED were studied. They were treated in a open label study with felbamate for a 22 months period. Felbamate monotherapy show a statistical significant improvement in the control of seizures in these patients versus CBZ therapy. No severe side effects were reported specially aplastic anemia or hepatic failure. At present, after 2 years, all the patients are still treated with felbamate. CONCLUSIONS: felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, sonnolence, diplopia, dizziness and insomnia) disturbances. These adverse effects last, generally, for three weeks and allow to continue the treatment.

Adolescent↗
PubMed1997

[Lamotrigine: monotherapy in refractory epilepsy].

CBZ (mean 1219 mg, DS +/- 94.6) + LTG (mean 55.8 mg, DS +/- 80) were administered in 31 subjects with refractory partial complex and/or partial secondary generalized seizures. The age ranged from 18 to 62 years (mean/yr 37.1, DS +/- 12.5). This first trial is concluded after a period of 8-12 months (mean 11.4, DS +/- 11.2). A follow trial with LTG at lower dose monotherapy ranged from 125-250 mg (mean 190.32, DS +/- 40.6) was conducted in same patients. There was a 82.2% (DS +/- 15.3) reduction in total seizure frequency with LTG monotherapy compared to LTG + CBZ = 53.5 (DS +/- 29.3). The difference remained highly significant (p < 0.0001) in favor of LTG monotherapy. The LTG leads major improvement if submitted like a single drug in therapy resistant epilepsy.

Adolescent↗
PubMed1993

Basilar migraine with electroencephalographic findings of occipital spike-wave complexes: a long-term study in seven children.

Basilar migraine is characterized by headache preceded by prodromal symptoms and signs of posterior cerebral circulation dysfunction. Few studies have focused on EEG findings in this condition or on the prognosis of occipital spike-wave complexes observed in either migraine or epilepsy. We now report a long-term follow-up (8-16 years) in seven children affected by basilar migraine who had EEG findings of occipital spike-wave complexes. Basilar migraine resolved and the EEG became normal in all subjects during the observation period, as did migraine with aura and seizures which developed in some of the patients after basilar migraine attacks ceased.

Basilar Artery↗
PubMed1986

Rolandic paroxysmal epilepsy: a long term study in 150 children.

150 children with Rolandic paroxysmal epilepsy (RPE) aged 3 to 12 years were followed up clinically and by EEG for 16 years. Antiepileptic drugs were administered initially for 2 years and then suspended for 6-12 months. Treatment was resumed in the 29 patients who had seizures during the drug-free interval and was maintained for a further 5 years. 80.6% of all patients were in clinical remission after the 2-year treatment period. Some patients had seizures while on drugs, others during the drug-free interval. Seizure frequency declined with age. No seizures occurred after the age of 14 or in the 8 years following final discontinuation of drug therapy. The need for prolonged drug treatment is therefore questioned.

Anticonvulsants↗
PubMedDate not supplied

[Lamotrigine in the therapy of resistant epilepsy].

OBJECTIVE: To evaluate the efficacy of lamotrigine as single agent in patients with refractory epilepsy. MATERIALS AND METHODS: Forty-seven adult patients with refractory epilepsy, in the initial phase received carbamazepine (1208 +/- 82.9 mg/day) plus lamotrigine (561.7 +/- 76.8 mg/day); during the second phase they received lamotrigine alone (206.4 +/- 44.4 mg/day). RESULTS: Lamotrigine monotherapy significantly improved the number of seizures per week in comparison to lamotrigine combined with carbamazepine (p < 0.0001). CONCLUSIONS: Lamotrigine as single agent is more effective than carbamazepine + lamotrigine in patients with refractory epilepsy.

Adolescent↗
PubMedDate not supplied

Migraine and other clinical syndromes in children affected by EEG occipital spike-wave complexes.

Twenty EEG recordings obtained in children showed temporo-parieto occipital or temporo-occipital spikes or spike-wave complexes suppressed by eye-opening. Patients showed different neurological syndromes: classic migraine, vertebrobasilar migraine, visual phenomena, epilepsy, psychomotor retardation. Thirteen subjects were affected by epileptic seizures, which were preceded by visual phenomena in 12 cases. In 6 cases, a combination of classic migraine, visual phenomena and seizures was found. In one case of vertebrobasilar migraine, seizures occurred 5 years after the first episode of migraine. Follow-up data indicate a non-benign evolution of occipital epilepsy: partial or generalized seizures persisted in 13 treated cases. Moreover, the EEG finding of occipital spike-wave complexes seems to extend to different neurological syndromes.

Adolescent↗
PubMedDate not supplied

[Efficacy of vigabatrin associated with carbamazepine in the treatment of epilepsy. Follow up 1993-1996].

PURPOSE: To verify tolerance and clinical efficacy of vigabatrin (VGB), a new antiepileptic drug, in an add-on therapy with carbamazepine (CBZ). PATIENTS AND METHODS: From september 1993 to december 1996, 35 patients with partial complex seizures (CPC) and CPC plus secondary generalization were treated, with VGB plus CBZ, VGB dose was 1.41 +/- 0.26 (g/die +/- SD) and CBZ 2.28 +/- 0.60 (g/die +/- SD). RESULTS: Patients were followed-up every 4 months showing an improvement between 61.5% and 68.8% from baseline. CONCLUSIONS: In all patients we observed an improvement during the follow-up period. Side effects were mild and well tolerated.

Adult↗