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Biomedical subjects

F Del Vecchio

Publications and source records attributed to F Del Vecchio.

9 recordsLinked to original sources
PubMed2000

Time evolution of acoustic 'information' processing in the mesencephalon of Wistar rats.

A traditional analysis of intra-encephalic auditory evoked potentials does not highlight the dynamical evolution of the auditory 'information' processing in neither time nor space. This work presents a method for tracing such signal evolution throughout the primary auditory pathway in the mesencephalon of adult anesthetized Wistar rats, using a unilateral 3 kHz tone burst stimulus. The results of the acoustic evoked potentials mapping are presented as conventional 20 ms recordings and re-analyzed in intervals of 1 ms-time windows. The parameter used, as an 'activity' correlate, was the maximum/minimum voltage difference obtained from each time window. The methodology used clearly indicates sequential signal propagation from the dorsal and ventral nuclei of the lateral lemniscus up to the inferior colliculus.

Acoustic Stimulation↗
PubMed1981

[The early development of the cranial segment of the müllerian duct in the rat].

In the rat the cranial part of the Muellerian duct (M-duct), i.e. the anlage of the uterine tube, is of dual origin. The different segments of the adult tube are already recognizable during embryogenesis and may be attributed to their original materials. The preampulla arises from the infundibular field of the coelomic epithelium (= MT). The isthmus is budding from the Wolffian duct (= MW). The middle segment of the tube, the ampulla, is organized by fusion of MT and MW. In the male rat embryo MW degenerates completely, whereas MT degenerates only partially. The remaining part of MT becomes to a solid structure close to the testis, namely the testicular appendage. In the rat testicular appendage is traceable until the first postnatal day.

Animals↗
PubMedDate not supplied

Cellular genetic therapy.

Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor. In fact, structures can be corrected and strengthened with the introduction of undifferentiated cells within specific target tissues, where they will specialize into the desired cellular types. Furthermore, consequent to the recent results obtained with the transdifferentiation experiments, a process that allows the in vitro differentiation of embryonic and adult stem cells, it has also became clear that many advantages may be obtained from the use of stem cells to produce drugs, vaccines, and therapeutic molecules. Since stem cells can sustain lineage potentials, the capacity for differentiation, and better tolerance for the introduction of exogenous genes, they are also considered as feasible therapeutic vehicles for gene therapy. In fact, it is strongly believed that the combination of cellular genetic and gene therapy approaches will definitely allow the development of new therapeutic strategies as well as the production of totipotent cell lines to be used as experimental models for the cure of genetic disorders.

Adult↗
PubMedDate not supplied

[Experimental toxicological and pharmacodynamic studies of a triple drug association (adrenaline, atropine and papaverine) with anti-bronchospastic activity].

The antibronchospastic value of the triple association adrenaline (1) + atropine (0,3) + papaverine (3) has been documented experimentally. Comparative investigations have been carried out with isoprenaline, metaproterenol, terbutaline and salbutamol. Toxicological and pharmacodynamic studies were done in the cardiovascular system and in vitro on certain muscles.

Administration, Oral↗