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F Delaini

Publications and source records attributed to F Delaini.

24 records · Page 2Linked to original sources
PubMed1981

Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.

This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.

Animals↗
PubMed1981

Interaction between heparin and adriamycin in mice bearing the Lewis lung carcinoma.

The investigation was prompted by the observation that adriamycin can interact with heparin in vitro and reduces its anticoagulant activity in ex vivo tests in humans. The possible interactions between these two drugs were studied in C57Bl/6J mice bearing the Lewis Lung Carcinoma (3LL). The anticoagulant activity of heparin was temporarily reduced by concomitant treatment with adriamycin, as indicated by both activated partial thromboplastin times and blood recalcification times. In contrast, no changes were found in the kinetics of adriamycin disappearance from blood and accumulation in tissues if mice had been pretreated with heparin. Moreover, the effect of adriamycin on tumour and metastasis growth was unchanged by the association with the anticoagulant. These data indicate that the short-lived interaction between adriamycin and heparin, which can be documented by coagulation tests, does not necessarily involve a modification in the anticancer activity of the anthracycline.

Animals↗