PubMed Health⌕ Search

Biomedical subjects

F Delbarre

Publications and source records attributed to F Delbarre.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Hydroxyapatite microcrystals in synovial mitochondria in human and experimental rheumatism].

This paper deals with mitochondria microcrystal deposition in some human inflammatory rheumatism and in experimental arthritis. Hydroxyapatite microcrystals were observed in Ankylosing Spondylitis (AS) and Reiter Syndrome (RS) but never in rheumatoid synovitis nor in chondrocalcinosis synovitis. In Rat and Rabbit experimental arthritis, they were always seen in mitochondria as in AS and RS and never in lysosomes. This fact suggests mitochondrial abnormalities in calcium metabolism, which may be a consequence of synovial inflammation in a susceptible host.

Animals↗
PubMed1981

[Chronic polyarthrosynovitis in the goat: histological and physicochemical study of an animal model of apatite crystallopathic rheumatism].

The aim of this paper is to describe clinical pattern and pathogenesis of spontaneous chronic polyarthritis observed in Swiss goats. Roentgenograms, histologic findings, ultrastructural study and microprobe analysis of synovium samples show apatite microcrystal deposit ion. Thus this spontaneous goat disease may be related to apatite microcrystal deposit ion disease in man, so called crystallopathic-hydroxyapatite rheumatism.

Animals↗
PubMed1981

[Crystallographic and molecular structure of trihexosyl-ceramide deposits characteristic of Fabry's disease (particularly the rheumatic form). Digital imaging processing].

The ceramide trihexoside inclusions, which characterize Fabry-Anderson disease, have been studied using electron microscopy and digital image processing. Results are given showing the various apparent periodicities of the inclusion lamellae and the orientation, perpendicular to the lamellae or oblique, of the ceramide molecular component.

Adipose Tissue↗
PubMed1981

[Ultrastructural and microanalytic study of gold depots in the synovial membrane of man and animals during treatment with sodium aurothiopropanol sulfonate].

In inflammatory rheumatism treated by gold therapy synoviocytes A are stuffed with gold salt deposits leading to a therapeutic thesaurismosis. These deposits are localized in lysosomes, then called aurosomes. However they may be rarely near collagen fibers or free, particularly in ankylosing spondylitis synovitis. Their structural morphological aspect is the same in several human rheumatic diseases and in rabbit experimental arthritis whatever the gold salt used. In such deposits, microprobe analysis shows gold and sulphur. This latter is probably given by the cell. Therapeutic effect of gold salts may imply the effect of the thiol moiety and the gold metal one.

Adult↗
PubMed1981

Lymphocyte nuclear refringence in two inbred strains of rat. Modifications of NRT during adjuvant arthritis.

Nuclear refringence test (NRT) was studied in two inbred strains of rats: Lewis (LEW) and Wistar AG (WAG), the first develops a severe arthritis while the later only slight inflammation. Before adjuvant injection, a good NRT to ConA, PHA and Isoprinosine was observed in LEW but a poor one in WAG. After adjuvant injection a striking difference appears between the two strains concerning ConA response: in LEW the response is significantly lower on day 14, while in WAG the initial poor response is not modified. These data suggest that in WAG the suppressor T lymphocytes are already activated in vivo and are no longer responsive in vitro. The responses to PHA and Isoprinosine are parallel in both strains, the NRT response diminishes on day 14 in LEW and on day 21 in WAG.

Animals↗
PubMed1981

[Treatment of rheumatoid arthritis with zinc sulfate. Results of a doubl-blind trial].

At the end of a double blind clinical test carried out in 35 patients with classical rheumatoid arthritis, or progressive and with certain diagnosis, it does not appear that zinc sulphate given by mouth at dose of 600 mg/24 hours (divided up into 3 doses) may be a valid basic treatment. In fact, none of the classical clinical criteria (Richtie index, Lee index, etc.) nor laboratory criteria (E.S.R.) show any statistically significant change after 4 and 8 months. The discrepancy between these results and those previously published in discussed.

Arthritis, Rheumatoid↗
PubMed1981

Effectiveness of levamisole in rheumatoid arthritis: Immune changes and long-term results.

After a double-blind trial of 4 months, 40 patients with RA were treated with 100 mg Levamisole. Clinical results were good or excellent in 50%. The immunological status is not a valuable criterion for the selection of patients apt to respond to Levamisole. A good correlation was found between clinical improvement, reduction of ESR, percentage of immunoblasts, rheumatoid factor titre and the enhancement of lymphoblastic response to polyclonal mitogens. The treatment maintenance rate for efficacy was much lower for Levamisole than for D-penicillamine.

Adult↗
PubMed1981

Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis.

The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis. After an initial "wash-out" period (3 days), each patient was given each of the three treatments for one week, in randomized sequence. The total dose of indoprofen (tablets) was 800 mg/die and that of indomethacin (capsules) 200 mg/die, in 4 daily doses after the main meals. The evaluation of effectiveness on a cumulative group of 102 cases from 18 centres showed statistically significant differences in favour of both active drugs compared to placebo, based on a series of objectives and subjective criteria. There was no significant difference between IP and IM, but on factorial analysis of correspondences, IP showed a greater difference from placebo. The patient's judgments also suggested that IP (800 mg/die) was slightly more effective than IM (100 mg/die). Adverse reactions were observed in 8.9% of the patients on IM treatment, 3.9% on IP and in 39% on PL. Laboratory variables showed no significant changes in the course of treatment.

Adult↗
PubMed1981

[Infectious sacroiliitis. Multicenter study of 214 cases].

Out of 214 cases of infective sacro-ileitis observed on Rheumatology Units, 65% were due to common bacteria, 25% were tuberculous and 10% due to brucellosis. Post-partum infections were early, severe and often due to streptococci. Sacrocoxalgia was accompanied in 50% of cases by another focus of active tuberculosis. Two clinical presentations are possible, either that of acute sacro-ileitis with a sudden onset, severe pain, frank infection and major impotence which is common in infections due to current bacteria; or the presentation may be that of subacute sacro-ileitis with progressive onset with little or no fever, pain and moderate impotence which may be due to any bacteria. Identification of the responsible organism depends on blood culture, bacterial sampling at the point of entry of the infection but, above all, direct swab or preferably needle biopsy. Bone scan may demonstrate early hyperfixation in the absence of any radiological signs. Prolonged antibiotic treatment is sufficient in most cases.

Adolescent↗
PubMed1981

[Follow-up study of patients with rheumatoid arthritis over a period of more than 10 years (1966-1978): analysis of disease progression and treatment in 100 cases (author's transl)].

A follow-up study was conducted in 100 rheumatoid arthritis patients, treated over the last 10 years with currently accepted therapy, after a period varying from 10 to 15 years following the onset of the disease: 20 p. cent were in Steinbrocker's stage I, 60 p. cent in stage II, 16 p. cent in stage III, and 4 p. cent in stage IV. When compared with a similar study conducted between 1948 and 1958, results demonstrated that the percentage of patients in stage I had not varied, but that only half as many patients were disabled (stages III and IV), due to insertion of lower limb surgical prostheses. Corticoid therapy had been necessary in 84 p. cent of the patients for variable periods. The 50 p. cent duration of the different treatments proposed during this 10-year period was 12 months for antimalarial drugs, 8 months for gold salts, and 12 months for D-penicillamine. Therapy was still effective after one year in 30 p. cent on antimalarial drugs, 27 p. cent on gold salts, 51 p. cent on D-penicillamine, and 21 p. cent on chlorambucil. Duration of efficacy of basic treatments is too short to cover the long progression of rheumatoid arthritis. New treatments are necessary, as the functional prognosis of this disease has not changed fundamentally over the last 15 years.

Adrenal Cortex Hormones↗
PubMed1981

[Spinal osteonecrosis in adults. Apropos of 4 cases].

The authors report on 4 cases of aseptic osteonecrosis of the vertebral matter in adult. The relatively rare localisation is the lot of elderly patients. It may follow cobalt therapy or corticotherapy and seems to be brought about by osteoporosis, hypertriglyceridemia and, perhaps, malignant lymphoidal proliferation. Histological confirmation of osteonecrosis was available in one case. The radiological aspect is characterised by settling, with heterogenic osteo-condensation and gaseous dissection of the vertebral matter. A double vertebral localisation is possible, and scintigraphical hyperfixation is common. The course is slowly favourable, with a symptomatic treatment.

Adrenal Cortex Hormones↗
PubMed1980

[Immunomodulating action of 2-methoxyethanol and homologous derivatives in rats].

The authors have measured the effects of methoxy-2 ethanol and derivatives or analogs on adjuvant arthritis in Rat, and the activity of methoxy-2 ethanol on humoral responsiveness to antigenic stimuli in Rat. Only methoxy-2 ethanol,1,2-dimethoxyethane and 1-methoxy 2 ethoxy ethane out of 13 tested derivatives, have an inhibitory activity on adjuvant arthritis. Methoxy-2 ethanol induces a significant depression of antibody production after immune stimuli and a significant effect on rejection of the skin graft. Although these results are of interest, toxicity of methoxy-2 ethanol will be a limiting factor for therapeutic use.

Animals↗
PubMed1980

[Interactions between rheumatoid factors and antinuclear autoantibodies: their occurrence in a concealed state in rheumatoid disease (arthritis); effect of D-penicillamine].

In this paper it is demonstrated that IgM rheumatoid factor (RF) can inhibit the detection of antinuclear antibodies (ANA) by the classical rat liver cryostat section method. This "inhibition" of IgG-ANA by IgM-RF may be due to the formation of high molecular weight complexes. It would be the same in vivo. This masking effect can explain interesting similarities and dissimilarities observed in the clinico-immunological profiles of rheumatoid arthritis and systemic lupus erythematosus. D-Penicillamine can restore ANA activity by dissociating ANA-RF complexes. A new technique is described for the detection of these masked ANA.

Animals↗
PubMed1980

[Evaluation of the long term effect of antirheumatic drugs with the survey rate method].

In the long term study of antirheumatic drugs, drop out of patients (for failure of effect or side effects) can analysed with "survey rate" methods. Survey rates become in drug tests "treatment continuation rates". With this method D-penicillamine and levamisole have been compared. Penicillamine has better "continuation rate" not because of better tolerance, but because of better long term effectiveness compared with levamisole.

Evaluation Studies as Topic↗