In vitro effect of reproterol upon pulmonary, cardiac, vascular and intestinal 3',5'-monophosphate phosphodiesterase nucleoside.
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Biomedical subjects
Publications and source records attributed to F Di Mezza.
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In vitro in vivo reproterol showed intense spasmolytic effects upon the trachea and bronchi against various spasm-including agents (histamine, acetylcholine, acetyl-beta-methylcholine, 5-hydroxytryptamine, BaCl2). A comparative study with various drug used in the treatment of asthma (isoprenaline, metaproterenol, salbutamol, clenbuterol, papaverine and atropine) has been conducted.
In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were. Plasma renin concentration decreased after injection of Althesin and thiopental while increased after injection of ketamine.
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The occlusion of bile duct reduced the microsomal cytochrome P-450 activity in the liver of rats. However, the effects of the inducer drug, phenobarbital, were not abolished.
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