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Biomedical subjects

F Didier

Publications and source records attributed to F Didier.

At least 19 recordsLinked to original sources
PubMed1991

[Purification of gelatinase secreted by human polynuclear neutrophils].

Gelatinase was purified from DFP treated human neutrophils which have been stimulated by the chemotactic peptide, N-formyl-methionyl-leucylphenylalanine. The secreted gelatinase was purified in two major steps: a gelatinase enriched fraction was recovered after a specific immunoadsorption of contaminant proteins from cytosol and immunoadsorption of proteins from specific or azurophilic granules; then gelatinase was isolated by affinity chromatography and FPLC gel filtration. Some kinetic properties of the Mr 94,000 purified enzyme were investigated.

Catalysis↗
PubMed1988

[MRI in the diagnosis of lissencephaly. Apropos of a case].

In a patient with clinical manifestations suggestive of brain malformation, CT showed lissencephaly with absent opercularization. The child had seizures but not a typical EEG of hypsarhythmia. MRI confirmed the diagnosis and showed heterotopic grey matter and abnormal basal ganglia. High grey-white matter contrast and the possibility of imaging the brain in sagittal, coronal and transverse planes make MRI the methode of choice for the evaluation of lissencephaly and other brain malformations.

Brain↗
PubMed1987

Multicystic dysplastic kidney: natural history from in utero diagnosis and postnatal followup.

Based on our experience with 13 in utero diagnoses we report the changes that may occur in the ultrasonic appearance of a multicystic dysplastic kidney. Macrocysts appear obvious only in the early third trimester of pregnancy. After reaching a maximum size the cysts start to involute either in utero or after birth, which may lead to a small noncystic mass, the so-called aplastic kidney, or even to complete disappearance of the entire dysplastic kidney. The dysplastic kidney seems vulnerable to anoxia or infection, and necrosis may supervene. The multicystic dysplastic kidney is a progressive and changing disorder. If its radiological appearance is typical management may be conservative with ultrasonic monitoring. Nephrectomy should be done if there is any abnormal clinical or ultrasonic change.

Female↗
PubMed1987

Development of the hypodysplastic kidney: contribution of antenatal US diagnosis.

Two cases of fetal perirenal uriniferous pseudocyst were diagnosed in utero with ultrasound studies. The perirenal collections resolved spontaneously in utero. Follow-up examination showed growth impairment of the affected kidney. At birth, no renal function was demonstrated in one case and only slight function in the other case. Pathologic examination showed a highly dysplastic kidney with extravasated urine in the case in which surgery was performed. Some hypodysplastic kidneys apparently result from acute in utero obstruction with secondary pyelocalyceal rupture. Renal dysplasia could render the kidney more vulnerable to such phenomena.

Adult↗
PubMed1986

Pulmonary sequestrations of the upper lobe in children: three presentations.

Pulmonary sequestrations are congenital abnormalities where nonfunctioning lung tissue receives its vascular supply from the systemic circulation (thoracic or abdominal aorta). It is necessary to establish the diagnosis in childhood when the lesions are uncomplicated. The authors present three cases of sequestration of the apex (2 extralobar and 1 atypical) with the main clinical and radiological features. Sequestrations in the upper lobe are rare, and the usual site is the left lower lobe. Plain x-rays show a dense opacity, sometimes air-filled and sometimes with an air-fluid level: angiography is currently the best mean for definitive diagnosis; however, computed tomography will probably be very useful in the future. Differential diagnosis includes tumours of the superior mediastinum (neurogenic tumours, digestive duplication, bronchogenic cysts, pheochromocytoma and hydatid cysts).

Angiography↗
PubMed1979

Giant lobar emphysema--neonatal diagnosis.

Giant emphysema of a lung lobe has distinctive features. Classically there is overdistension of the affected lung lobe, with one lobe only being involved, and, 50% of cases occur in the newborn infant [1, 4, 8]. The authors describe a particularly severe example with marked mediastinal shift and initially the hemithorax on the side of the lesion was opaque. Angiography was carried out and followed by resection when the infant was 4 months old.

Angiocardiography↗
PubMed1977

[Neonatal aortic valvular stenosis. Apropos of 8 cases].

Congenital aortic stenosis presenting in the neonate must be distinguished from the commoner hypoplastic left heart-syndrome, which is beyond surgical correction. It is certainly a serious problem, but early diagnosis and supporting angiography to rule out the presence of an associated left ventricular malformation and to check the volume of the left ventricular cavity should lead to a decision to operate. Out a 4 neonates from this series who were presented for surgery, the 2 survivors had good long-term results.

Aortic Valve Stenosis↗
PubMed1975

[A case of parieto-pulmonary acquired shunt presenting with hemoptysis (author's transl)].

The authors report the case of a 52 year old man with arteriovenous shunt developing from the 7th left intercostal artery, revealed by hemoptysis and proved by intercostal selective arteriography. The patient had a past history of serofibrinous pleurity 29 years previously and had undergone paracentesis at this level. The origin of this shunt is then discussed.

Angiography↗
PubMed1975

[Ebstein's malformation in newborn infants. Apropos of 8 cases].

In relation with 8 cases, the features of Ebstein's malformation were studied in the neonatal form. In spite of its rarity, it should be recognized because of its peculiar prognosis, as it is liable to be permanently improved by medical treatment, after a difficult adaptation period. Besides, it is essential to distinguish it from other neonatal heart diseases which ressemble to it, but require an urgent surgical treatment.

Humans↗
PubMedDate not supplied

[The Kasabach-Merritt syndrome with pancreatic localization in a newborn infant].

The case of a neonate with a large pancreatic hemangioma belonging to the Kasabach-Merritt syndrome is reported. Selective embolization of one of the main vessels originating from the gastroduodenal artery resulted in a progressive increase of blood platelet levels and in a concomitant change in the hemangiomatous structure at ultrasound examination, as well as in a subsequent acceleration of somatic growth. At 8 months of age, there were no more clinical, radiological, ultrasonographic or biological signs of the hemangioma. This case report emphasizes the interest of embolization in the Kasabach-Merritt syndrome.

Embolization, Therapeutic↗