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Biomedical subjects

F Driessen

Publications and source records attributed to F Driessen.

10 recordsLinked to original sources

Postpartum pelvic arthropathy with unusual features.

Eleven patients seen in Malawi are described with a syndrome of postpartum pelvic arthropathy. They complained of severe pain mainly located in the symphysis pubis and all were unable to walk. The following unusual features were noted: the absence of obstetric trauma, a symptom-free interval between the delivery and the onset of the syndrome, the absence of gross widening of the symphysis pubis and the lack of abnormal mobility in the same joint. It is speculated that the syndrome described is not caused by rupture of the symphysis or softening under the influence of hormones but by swelling inside the intact fibrous confines of the joint.

Adult↗

Serum progesterone and oestradiol concentrations in women with unexplained infertility.

Twenty-eight patients with longstanding, unexplained infertility were studied during one menstrual cycle by serial serum progesterone and oestradiol assays. For comparison the serum concentrations of these hormones were also measured during one cycle in ten fertile control subjects. Of the patients with infertility, one had an anovulatory cycle and one had a cycle with a short luteal phase. In the other 26 patients the length of the cycle, the preovulatory peak oestradiol concentration and the maximum oestradiol concentration during the luteal phase were less than in the controls but these differences were not statistically significant (p > 0.10). However, the duration of progesterone secretion and the maximum progesterone concentration during the luteal phase were significantly less (p < 0.01) in the patients with infertility than in the controls. It is, however, uncertain whether the subnormal progesterone secretion is responsible for the infertility.

Adult↗

The significance of dating an endometrial biopsy for the prognosis of the infertile couple.

Two hundred and thirty-two women with primary or secondary infertility were divided into four groups according to their endometrial biopsy result: 114 (49%) with no delay of the secretory phase, 36 (16%) with a secretory phase with a delay of 2 days, 26 (11%) with a secretory delay of 3 days or more, and 56 (24%) with an endometrium which could not be dated because of inadequate material. The cumulative pregnancy rate of all patients was 53% within 2 years and the pregnancy rates of the four groups did not differ significantly. In our department the histological dating of an endometrial biopsy as part of the initial investigation of the infertile couple is not worthwhile.

Biopsy↗

The nutritional status of children ages 0-5 years in Nkhotakota, Malawi.

A nutritional status survey of children aged 0-5 years was carried out in a lake shore district in Malawi. Anthropometric and clinical studies indicated a high overall prevalence (14%) of Protein-Calorie Malnutrition (PCM), particularly among the 1- to 1 1/2-year-olds. Few signs of vitamin deficiencies were seen but iron deficient anaemia was common at all ages, 68% being below the acceptable haemoglobin level. Sixty percent of children had malaria parasitaemia and 25% conjunctivitis. Under-five mortality was estimated to lie between 31 and 44%. Muslim children had a higher mortality and prevalence of PCM and fewer of their fathers had been to school. It is suspected that many cases of undernutrition go unrecognized because of uniform stunting occurs and ages are not known. It is recommended therefore that medical units use a local calendar, similar to that evolved for the survey, in order to estimate ages more accurately.

Adolescent↗