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Biomedical subjects

F Dulitzky

Publications and source records attributed to F Dulitzky.

34 records · Page 2Linked to original sources
PubMed1987

Production of interleukin-1 by mononuclear cells of newborns and their mothers.

The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity of IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.

Adult↗
PubMed1987

Difference in the placental ferritin levels measured by a specific monoclonal antibody enzymoassay in preterm and term delivery.

The use of a new monoclonal antibody (MoAb) enzymoassay for the specific measurement of placental ferritin (PLF) enabled it to be quantitatively determined in the sera of pregnant women, women at full-term and preterm delivery, and in their newborns. High levels of PLF were measured in the sera of pregnant women at 17 weeks of gestation up to full-term delivery as compared with normal adult women who mostly lack PLF. The level of PLF in the serum was irrespective of the total ferritin level. In full-term newborns, PLF concentration was lower than that found in their mothers although it increased compared to healthy adults. It was further found that in the blood of women who delivered at 29-36 weeks, PLF was undetected or was very low. Accordingly their preterm infants also exhibited very low or undetectable PLF in their serum. These results suggest the possible use of PLF as a prognostic indicator in pregnancy.

Adult↗
PubMed1987

An infant with multiple deformations born to a myasthenic mother.

An infant with multiple deformations born to a mother with untreated myasthenia gravis presented with arthrogryposis multiplex, craniofacial dysmorphism, kyphoscoliosis of the thoraco-lumbar spine, severe hypotonia, absence of the sucking reflex, and other neurological deficits. The neurological state of the infant supported the diagnosis of congenital myasthenia gravis, but the negative Tensilon test and the lack of clinical improvement after prolonged Mestinon treatment ruled out this diagnosis. We believe that the multiple deformations and reduced fetal movements are related to the maternal myasthenic environment associated with mild polyhydramnion.

Abnormalities, Multiple↗
PubMed1986

Cord serum inhibits allogeneic mixed lymphocyte reaction and stimulates lymphokine production.

An inhibitory activity on the two-way allogeneic mixed lymphocyte reaction (MLR) was detected in maternal and cord serum at delivery. The inhibitory effect of the maternal serum was found to be more pronounced and was detected in almost all sera tested, whereas the inhibitory capacity of cord sera was observed in only 70% of the cases. In addition, a lower stimulatory activity for interleukin-2 (IL-2) production was found in the maternal serum, suggesting an additional mechanism for the suppression of the maternal immune system during pregnancy. On the other hand, a higher stimulatory activity for IL-2 production was observed in cord serum as compared with adult normal serum. The possibility that a fetal humoral factor is involved in the regulation of the immune system via the stimulation of IL-2 production is discussed.

Adult↗
PubMed1986

Thrombopoietic activity in preterm newborns and infants.

Platelet count and thrombopoietic activity were investigated in preterm infants at birth and during their first four months of life. Thrombopoiesis stimulating factor activity in cord serum was significantly lower than that of adults and of the respective mothers. No difference was noted between thrombopoietic activity in cord serum in the various gestational ages studied--that is, 24 through 39 weeks. Preterm infants followed during their first four months of life showed a mean platelet count significantly higher than that observed in term infants at the respective age. Furthermore, thrombocytosis was found in premature thriving infants at the age of 1 and 2 months. It is suggested that this thrombocytosis is responsible for the low thrombopoietic activity observed in these infants during their first four months of life.

Adult↗
PubMed1986

Thrombopoietic activity in newborn infants.

Platelet count and thrombopoietic activity were investigated in newborns and in infants during their first 4 months of life. Four-day-old newborns, although not thrombocytopenic, showed a significantly reduced platelet count as compared to that of control adults. Furthermore, a significantly lower thrombopoietic activity was found in the sera of newborns compared to that in the sera of adults. In addition, the thrombopoiesis-stimulating factor (TSF) activity in cord serum was significantly lower than that in the mothers' sera. Since 7 of 37 newborns examined in the present study showed a very low TSF activity, lower than that found in the saline controls, the possibility that an inhibitor for thrombopoiesis exists in the newborns is suggested and discussed. The follow-up study revealed a low TSF activity in the sera of 1-month-old infants followed by a gradually increased activity, reaching in the 4th month levels similar to those of adults. Concomitantly with the rise in TSF activity in the serum, an increased platelet count was observed.

Blood Platelets↗
PubMed1986

Bart's syndrome: a mechanobullous disease of the newborn. Report of five cases and review.

Bart's syndrome is one among the lesser known presentations of epidermolysis bullosa. It is characterized by congenital localized bullae of skin and mucous membranes sometimes associated with nail deformities, all of which disappear during the neonatal period. Early recognition allows for avoidance of inappropriate systemic or local therapy.

Diagnosis, Differential↗
PubMed1986

Congenital anterior urethral diverticulum associated with bilateral urinomas and dysplastic kidneys.

Congenital anterior urethral diverticulum (AUD) is a rare condition. We report a case of AUD associated with urinary ascites, bilateral urinomas and dysplastic kidneys. The diagnosis of urethral obstruction was established in utero by means of ultrasound. The right perirenal urinoma appeared "septated", and we believe that this is related to its hemorrhagic content. Improvement of the clinical condition and renal function was noted after decompression by bilateral cutaneous loop ureterostomy.

Diverticulum↗
PubMed1985

Sialic acid in newborn and maternal lymphocytes: preterm deliveries.

Sialic acid was determined in newborn and maternal lymphocytes immediately after preterm deliveries of 34 and 35 weeks of gestation. The results were compared with those found in full-term deliveries. In contrast with full-term deliveries, in preterm deliveries a significant increase in sialic acid in maternal as compared to newborn lymphocytes was found. However, the mean cumulative value of sialic acid for maternal and newborn lymphocytes was similar in both groups. In addition to this, sialic acid concentrations seem to be sex-dependent and higher mean cumulative values for maternal and newborn lymphocytes could be found for male as compared to female newborns after full- as well as after preterm deliveries.

Female↗
PubMed1985

Neonatal factor XIII deficiency.

We describe a patient diagnosed in the neonatal period as having factor XIII deficiency who presented with persistent umbilical bleeding. Factor XIII deficiency is the only coagulation factor deficiency that cannot be detected by classical hemostatic tests, and a rapid diagnosis is vital during the first decade of life. A newborn presenting with persistent umbilical stump bleeding should be screened for factor XIII deficiency when routine coagulation tests prove normal.

Blood Coagulation Tests↗
PubMed1985

Neuroendocrine study of a male infant with septo-optic dysplasia.

Septo-optic dysplasia includes abnormalities of the optic nerves and tracts with absence of the septum pellucidum. Most of the recently reported patients were deficient in growth hormone. We describe a male infant with septo-optic dysplasia in whom extensive endocrine evaluation revealed central diabetes insipidus, hypothalamic hypothyroidism and combined (hypothalamic-pituitary) hypoadrenalism, along with normal pituitary growth hormone reserve. This is the first reported case of a patient with septo-optic dysplasia who underwent corticotropin-releasing factor and growth hormone-releasing hormone stimulation.

Adrenal Glands↗
PubMed1985

Transient obstruction of the kidney and hypertension due to neonatal adrenal hemorrhage. Case report.

A case of neonatal adrenal hemorrhage associated with transient obstruction of the kidney and hypertension is reported. Sonography demonstrated a mass in the right suprarenal area, consistent with hemorrhage into the adrenal gland. DTPA renal scan showed prolonged retention of the injected material in the right kidney, consistent with obstructed outflow from the renal collecting system. Gradual decrease in the size of the suprarenal mass was associated with relief of the renal obstruction as evidenced by a normal repeat renal scan, and a return to normal of the blood pressure. It appears that the cause for the hypertension was the acute renal obstruction, which was due to either direct pressure on the proximal ureter by a large adrenal mass or secondary to displacement of the kidney by the mass resulting in kinking of the proximal ureter.

Adrenal Gland Diseases↗
PubMed1984

New anomalies found in the 11q-syndrome.

The cytogenetic analysis of an infant with multiple congenital anomalies revealed a small deletion of the long arm of one No. 11 chromosome: 46XX del 11 (q23-q25). The main clinical manifestations included: trigonocephaly, flat broad nasal bridge, micrognathia, carp mouth, hypertelorism, low set ears, severe congenital heart disease, anomalies of limbs and external genitalia. In comparison to the previously reported cases of 11q-, the patient presented here had congenital anomalies not described before, including severe affected urogenital system, hypoplasia of the adrenal, accessory spleens and mild hydrocephaly.

Abnormalities, Multiple↗
PubMed1981

Unilateral radial aplasia and trisomy 22 mosaicism.

A child with unilateral radial aplasia, asymmetry, other malformations, and severe physical and mental retardation is reported. In blood and bone marrow cultures a low mosaicism for trisomy 22 was found. In a few cells a chromosome 22 was missing. The importance of early cytogenetic analysis on large numbers of cells is emphasised, especially in cases of asymmetry where mosaicism is suspected.

Abnormalities, Multiple↗