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Biomedical subjects

F Duron

Publications and source records attributed to F Duron.

At least 37 records · Page 2Linked to original sources
PubMed1987

Clinical value of thyrotropin binding inhibiting immunoglobulins (TBII) assay in hyperthyroidism.

More than 500 sera were assayed for TBII under routine conditions using "Trak" assay in order to evaluate the sensitivity, specificity and prognostic interest of this determination in hyperthyroidism. The sensitivity for the diagnosis of Graves' disease was 83.5%, better in ophthalmopathic patients (93%) than in non ophthalmopathic patients (75%). The specificity was 99.4% with only one false positive in a hypothyroid patient. TBII level significantly decreases with carbimazole treatment except in patients who remain hyperthyroid. Determination of TBII before stopping carbimazole treatment or after surgery has a prognostic significance as a positive value indicates a relapse in almost all cases. Conversely, a fall of TBII to normal levels with treatment is insufficient to assess recovery. High levels are frequently observed after radioiodine therapy but do not indicate a poor prognosis.

Carbimazole↗
PubMed1986

Association of parathyroid adenoma and autonomous nodule of the thyroid. Diagnostic efficacy of 201thallium-99mtechnetium scintigraphy.

The thallium-technetium subtraction technique, proposed originally by Ferlin and co-workers, is now widely used to localize parathyroid adenoma. We report here the case of a hypercalcemic woman, referred to our ward with the biologically assessed diagnosis of primary hyperparathyroidism. Thallium-technetium subtraction scintigraphy not only successfully localized the parathyroid adenoma but also revealed the existence of an autonomous nodule of the thyroid, which was not suspected. It has previously been shown that this method can localize parathyroid adenoma in cases of cold thyroid nodule. This report shows that this is also true in the case of hot thyroid nodule. No observations of concomitant parathyroid adenoma and autonomous nodule of the thyroid have been reported (at least during the two past decades). Is this association casual or has it never been noticed? Further examinations can be performed with thallium when a hot thyroid nodule is found in a hypercalcemic patient.

Adenoma↗
PubMed1984

[Glycosylated hemoglobin in pregnant women with glycosuria].

Systematic assays of glycosylated haemoglobin were performed to verify that pregnant women with glycosuria and normal fasting blood glucose and glucose tolerance tests had no disturbances in glycoregulation . Glycosylated haemoglobin levels were measured in 25 glycosuric women on the second (n = 11) or third (n = 14) trimester of pregnancy and compared with those of 81 non-glycosuric women of similar weight and gestational age. On the third trimester, glycosylated haemoglobin levels were significantly higher in glycosuric women of normal weight than in controls (5.85% versus 5.08%; p less than 0.01). They were also significantly higher in obese glycosuric women than in controls of the same weight (6.71% versus 5.3%; p less than 0.001) and exceeded normal limits. These results should encourage better detection (by glucose tolerance test) and better supervision of women with "renal" diabetes.

Adult↗
PubMed1982

[Detection of peripheral diabetic neuropathy. A reappraisal of electrophysiological data].

In addition to motor and sensory nerve conduction, monosynaptic triceps surae reflex, amplitude of median nerve voltage and response of extensor digitorum brevis and soleus muscles were investigated in 29 diabetic patients. These parameters were altered earlier than motor and sensory nerve conduction, which considerably increased the incidence of subclinical peripheral neuropathy (90% of the patients). It was also found that sensory fibers were affected earlier than motor fibers. The electrically detected neuropathy correlated with duration of diabetes and control of glycaemia.

Axons↗
PubMed1982

[Long-term evolution of anorexia nervosa: quantitative evaluation].

Out of 50 patients with anorexia nervosa observed at Saint-Antoine's Hospital, Paris, between 1969 and 1979, 34 were examined in 1980-1981 or had answered a questionnaire. Intermediate (2/3 years) and long term (more than 4 years) outcome were estimated for 28 and 29 patients respectively, based upon 5 items groups, each of them assessed 0, 0,5 or 1: weight, menstruation, social family and sex adjustment, psychological state and attitude towards feeding. Data were available for intermediate and long-term outcome for 23 patients. Good results (score 0 to 1) were obtained more often in the long term (34,5 p. cent) than in the intermediate (14.3 p. cent) outcome (P less than 0.01). This improvement is related to better weight (P less than 0.05), social family and sex adjustment (P less than 0.01) and possibly menstruations. Others items haven't been changed by time. Poor results (score more than 3) represent also 34,5 p. cent of the cases and we grieve 3 deaths. Past 4 years there were no more changes in the outcome. Only initial weight loss is significantly correlated with long term outcome (P less than 0.01). Social class, age of onset previous weight, trigger circumstances, duration of illness before admission, number of physicians involved during the evolution . . . had no prognostic value. Anorexia nervosa appears as a severe disease, which long duration justified all our efforts.

Adolescent↗
PubMed1979

[Therapeutics future of liposomes (author's transl)].

The possibility to use the liposomes as drug vehicles has been largely investigated in recent years. Most of the studies have been carried out in animals and are related to disease involving predominantly the reticulohistiocytic system. Attempts to use these liposomes orally (induced diabetes) or locally (induced arthritis) are also reported. Further trials are required to get a better knowledge of the mechanisms involved in the exchanges between the cell membrane and the liposome the latter being variable as regards its composition, size and permeability according to the various investigators; the adjustment to the liposome of a complex capable to electively direct it towards the target organ is studied.

Administration, Oral↗
PubMed1979

[Stenosis of the aqueduct of Sylvius and their endocrine manifestations (author's transl)].

In a 14-year-old boy, neurological signs (fall in visual acuity, signs of raised intracranial pressure) led to a diagnosis of stenosis of the aqueduct of Sylvius. Cure was obtained by insertion of a ventriculo-cardiac bypass (Holter's valve). Endocrine signs (delayed growth, excessweight, loss of circadian variations in cortisol levels) regressed in a few months after the operation. Amongst endocrine manifestations of stenosis of the aqueduct, delayed growth and disturbances in gonadal function are the most common, together with obesity. They usually regress after neurosurgical treatment.

Adolescent↗
PubMed1979

[Hemochromatosis and puryvate kinase deficiency (author's transl)].

A 25-year-old man with familial pyruvate kinase (PK) deficiency who have been given only 6 transfusions during his lifetime died of cardiac failure from hemochromatosis (HC). This previously unreported association of PK and HC deficiency does not appear to be fortuitous but to be related to possible early hemolysis and intramedullary destruction, features of ineffective erythropoiesis. The role of splenectomy in the progression of the HC could, as in some thalassemias, be an unfavourable factor. Serum iron levels should therefore be measured during the course of AHPK.

Adult↗
PubMed1976

[Adrenal insufficiencies caused by isolated corticotropic deficiency. 2 cases].

Isolated adrenocorticotropin deficiencies are rare. Two cases are reported, one, with hypoglycaemia, the other with weakness and hypotension, with a review of the published cases during the past twenty years. The adrenal defect impairs severely the glucocorticoid secretion while aldosteron is normal. Tetracosactid stimulates adrenal secretion. ACTH activity measurable in serum is very low and not affected by metyrapone. Other pituitary secretions are normal. The hypothalamic or pituitary level of the defect will be situated when CRH test available.

Adrenal Insufficiency↗